http://www.legislation.gov.uk/id/eur/1990/2377/annex/III

F1ANNEX IIILIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES USED IN VETERINARY MEDICINAL PRODUCTS FOR WHICH PROVISIONAL MAXIMUM RESIDUE LIMITS HAVE BEEN FIXED

Annotations:

Amendments (Textual)

Substituted by Commission Regulation (EC) No 508/1999 of 4 March 1999 amending Annexes I to IV to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

1.Anti-infectious agents

1.1.Chemotheurapeutics

1.1.2.Benzenesulphonamides

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Clorsulon	Clorsulon	Bovine	50 μg/kg	Muscle	Provisional MRLs expire on 1 January 2000
			150 μg/kg	Liver
			400 μg/kg	Kidney

1.2.Antibiotics

1.2.1.Beta-lactamase inhibitors

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Clavulanic acid	Clavulanic acid	Bovine, ovine	200 μg/kg	Milk	F10Provisional MRLs expire on 1 July 2001
		Bovine, ovine, porcine	200 μg/kg	Muscle
			200 μg/kg	Fat
			200 μg/kg	Liver
			200 μg/kg	Kidney

1.2.2.Macrolides

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
F4Acetylisovaleryltylosin	Sum of acetylisovaleryltylosin and 3-O-acetyltylosin	Porcine	100 μg/kg	Muscle	Provisional MRLs expire on 1.7.2001
			100 μg/kg	Skin and fat
			100 μg/kg	Liver
			100 μg/kg	Kidney
Erythromycin	MRLs apply to all microbiological active residues expressed as erythromycin equivalent	Bovine, ovine	40 μg/kg	Milk	Provisional MRLs expire on 1 June 2000
		Bovine, ovine, porcine, poultry	400 μg/kg	Muscle
			400 μg/kg	Fat
			400 μg/kg	Liver
			400 μg/kg	Kidney
		Poultry	200 μg/kg	Eggs
Josamycin	Josamycin	Chicken	200 μg/kg	Muscle	F14Provisional MRLs expire on 1.7.2002
			200 μg/kg	Fat
			200 μg/kg	Liver
			400 μg/kg	Kidney
			200 μg/kg	Eggs
F12	Sum of the microbiologically active metabolites, expressed as josamycin	Porcine	200 μg/kg	Muscle	Provisional MRLs expire on 1.7.2002
			200 μg/kg	Skin and fat
			200 μg/kg	Liver
			400 μg/kg	Kidney
F8Tilmicosin	Tilmicosin	Bovine	40 μg/kg	Milk	Provisional MRLs expire on 1.1.2001
F11Tulathromycin	(2R,3S,4R,5R,8R,10R,11R,12S, 13S,14R)-2- ethyl-3,4,10,13-tetrahydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa- 6-azacyclopent-decan-15-one expressed as tulathromycin equivalents	Bovine	100 μg/kg	Fat	Provisional MRLs expire on 1 July 2004; not for use in animals from which milk is produced for human consumption
			3 000 μg/kg	Liver
			3 000 μg/kg	Kidney
		Porcine	100 μg/kg	Skin and fat	Provisional MRLs expire on 1 July 2004
			3 000 μg/kg	Liver
			3 000 μg/kg	Kidney

F71.2.4.Cephalosporins

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Cefacetrile	Cefacetrile	Bovine	125 μg/kg	Milk	F15Provisional MRLs expire on 1.1.2002 For intrammamary use only
F5Cefalonium	Cefalonium	Bovine	10 μg/kg	Milk	F16Provisional MRLs expire on 1.1.2003
F13Cefoperazone	Cefoperazone	Bovine	50 μg/kg	Milk	Provisional MRLs expire on 1 January 2001
F17Cefquinome	Cefquinome	Porcine	50 μg/kg	Muscle	Provisional MRLs expire on 1.1.2000
			50 μg/kg	Skin + fat
			100 μg/kg	Liver
			200 μg/kg	Kidney
Cephapirin	Sum of cephapirin and desacetylcephapirin	Bovine	50 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			50 μg/kg	Fat
			50 μg/kg	Liver
			100 μg/kg	Kidney
			10 μg/kg	Milk

1.2.5.Aminoglycosides

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Aminosidine	Aminosidine	Bovine, porcine, rabbits, chicken	500 μg/kg	Muscle	Provisional MRLs expire on 1 July 2000
			1 500 μg/kg	Liver
			1 500 μg/kg	Kidney
Apramycin	Apramycin	Bovine	1 000 μg/kg	Muscle	Provisional MRLs expire on 1 July 1999
		For use in non-lactating cattle only	1 000 μg/kg	Fat
			10 000 μg/kg	Liver
			20 000 μg/kg	Kidney
		Porcine	1 000 μg/kg	Muscle
			1 000 μg/kg	Skin and fat
			1 000 μg/kg	Liver
			5 000 μg/kg	Kidney
F18Dihydrostreptomycin	Dihydrostreptomycin	Bovine, ovine	500 μg/kg	Muscle	Provisional MRLs expire on 1.6.2002
			500 μg/kg	Fat
			500 μg/kg	Liver
			1 000 μg/kg	Kidney
			200 μg/kg	Milk
		Porcine	500 μg/kg	Muscle
			500 μg/kg	Skin and fat
			500 μg/kg	Liver
			1 000 μg/kg	Kidney
Gentamicin	Gentamicin	Bovine	100 μg/kg	Milk	Provisional MRLs expire on 1.6.2002
		Bovine, porcine	50 μg/kg	Muscle
			50 μg/kg	Fat
			200 μg/kg	Liver
			750 μg/kg	Kidney
F6Kanamycin	Kanamycin	Rabbits	100 μg/kg	Muscle	F19Provisional MRLs expire on 1.1.2004
			100 μg/kg	Fat
			600 μg/kg	Liver
			2 500 μg/kg	Kidney
		Bovine, ovine	100 μg/kg	Muscle
			100 μg/kg	Fat
			600 μg/kg	Liver
			2 500 μg/kg	Kidney
			150 μg/kg	Milk
		Porcine, chicken	100 μg/kg	Muscle
			100 μg/kg	Skin + fat
			600 μg/kg	Liver
			2 500 μg/kg	Kidney
F18Neomycin (including framycetin)	Neomycin B	Bovine, porcine, chicken	500 μg/kg	Muscle	Provisional MRLs expire on 1.6.2002
			500 μg/kg	Fat
			500 μg/kg	Liver
			5 000 μg/kg	Kidney
		Bovine	500 μg/kg	Milk
		Chicken	500 μg/kg	Eggs
Spectinomycin	Spectinomycin	Bovine	200 μg/kg	Milk	Provisional MRLs expire on 1 July 2000
		Bovine, porcine, poultry	300 μg/kg	Muscle
			500 μg/kg	Fat
			2 000 μg/kg	Liver
			5 000 μg/kg	Kidney
F5		Ovine Not for use in animals from which milk is produced for human consumption	300 μg/kg	Muscle	Provisional MRLs expire on 1.1.2002
			500 μg/kg	Fat
			2 000 μg/kg	Liver
			5 000 μg/kg	Kidney
		Chicken	200 μg/kg	Eggs
F18Streptomycin	Streptomycin	Bovine, ovine	500 μg/kg	Muscle	Provisional MRLs expire on 1.6.2002
			500 μg/kg	Fat
			500 μg/kg	Liver
			1 000 μg/kg	Kidney
			200 μg/kg	Milk
		Porcine	500 μg/kg	Muscle
			500 μg/kg	Skin and fat
			500 μg/kg	Liver
			1 000 μg/kg	Kidney

1.2.6.Quinolones

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
F12Danofloxacin	Danofloxacin	Porcine	100 μg/kg	Muscle	Provisional MRLs expire on 1.1.2000
			50 μg/kg	Skin and fat
			200 μg/kg	Liver
			200 μg/kg	Kidney
Decoquinate	Decoquinate	Bovine, ovine	500 μg/kg	Muscle	Provisional MRLs expire on 1 July 2000
			500 μg/kg	Fat
			500 μg/kg	Liver
			500 μg/kg	Kidney
F9Difloxacin	Difloxacin	Bovine Not for use in animals from which milk is produced for human consumption	400 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			100 μg/kg	Fat
			1 400 μg/kg	Liver
			800 μg/kg	Kidney
		Porcine	400 μg/kg	Muscle
			100 μg/kg	Skin and fat
			800 μg/kg	Liver
			800 μg/kg	Kidney
Enrofloxacin	Sum of enrofloxacin and ciprofloxacin	Ovine	100 μg/kg	Muscle	Provisional MRLs expire on 1 July 1999
			100 μg/kg	Fat
			300 μg/kg	Liver
			200 μg/kg	Kidney
Flumequine	Flumequine	Bovine, ovine, porcine, chicken	50 μg/kg	Muscle	Provisional MRLs expire on 1 January 2000
			50 μg/kg	Fat or skin and fat
			100 μg/kg	Liver
			300 μg/kg	Kidney
		Salmonidae	150 μg/kg	Muscle and skin
Marbofloxacin	Marbofloxacin	Bovine	150 μg/kg	Muscle	Provisional MRLs expire on 1 July 2000
			50 μg/kg	Fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
			75 μg/kg	Milk
		Porcine	150 μg/kg	Muscle
			50 μg/kg	Skin and fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
F7F3Oxolinic acid30	Oxolinic acid	Bovine31	100 µg/kg	Muscle
			50 µg/kg	Fat
			150 µg/kg	Liver
			150 µg/kg	Kidney
		Porcine	100 μg/kg	Muscle
			50 μg/kg	Skin + fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
		Chicken	100 μg/kg	Muscle
			50 μg/kg	Skin + fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
			50 μg/kg	Eggs
		Fin fish	300 μg/kg	Muscle and skin in natural proportions
Provisional MRLs expire 1 January 2006.
Not for use in animals from which milk is produced for human consumption.

1.2.9.Polymyxins

Phamarcologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Colistin	Colistin	Bovine, ovine	50 μg/kg	Milk	F14Provisional MRLs expire on 1.7.2002
		Bovine, ovine, porcine, chicken, rabbits	150 μg/kg	Muscle
			150 μg/kg	Fat
			150 μg/kg	Liver
			200 μg/kg	Kidney
		Chicken	300 μg/kg	Eggs

1.2.10.Penicillins

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
F7Nafcillin	Nafcillin	Bovine	300 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			300 μg/kg	Fat
			300 μg/kg	Liver
			300 μg/kg	Kidney
			30 μg/kg	Milk
Penethamate	Benzylpenicillin	Ovine	50 μg/kg	Muscle	Provisional MRLs expire on 1 January 2000
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			4 μg/kg	Milk
		Porcine	50 μg/kg	Muscle
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney

1.2.11.Florfenicol and related compounds

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Florfenicol	Sum of florfenicol and its metabolites measured as florfenicol-amine	Fish	1 000 μg/kg	Muscle and skin in natural proportions	Provisional MRLs expire on 1 July 2001
F7Thiamphenicol	Thiamphenicol	Ovine	50 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
		Porcine	50 μg/kg	Muscle
			50 μg/kg	Skin + fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
		Fin fish	50 μg/kg	Muscle and skin in natural proportions

F121.2.12.Polypeptides

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Bacitracin	Bacitracin	Bovine	150 μg/kg	Milk	Provisional MRLs expire on 1.7.2001

F71.2.13.Lincosamides

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Lincomycin	Lincomycin	Ovine	100 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			50 μg/kg	Fat
			500 μg/kg	Liver
			1 500 μg/kg	Kidney
			150 μg/kg	Milk
		Porcine	100 μg/kg	Muscle
			50 μg/kg	Skin + fat
			500 μg/kg	Liver
			1 500 μg/kg	Kidney
		Chicken	100 μg/kg	Muscle
			50 μg/kg	Skin + fat
			500 μg/kg	Liver
			1 500 μg/kg	Kidney
			50 μg/kg	Eggs
F12Pirlimycin	Pirlimycin	Bovine	100 μg/kg	Muscle	Provisional MRLs expire on 1.7.2000
			100 μg/kg	Fat
			1 000 μg/kg	Liver
			400 μg/kg	Kidney
			100 μg/kg	Milk

F51.2.14.Pleuromutilines

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Tiamulin	Sum of metabolites that may be hydrolysed to 8-a-hydroxymutilin	Turkey	100 μg/kg	Muscle	Provisional MRLs expire on 1.7.2001
			100 μg/kg	Skin and fat
			300 μg/kg	Liver