ANNEX IIILIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES USED IN VETERINARY MEDICINAL PRODUCTS FOR WHICH PROVISIONAL MAXIMUM RESIDUE LIMITS HAVE BEEN FIXED
1.
Anti-infectious agents
1.1.
Chemotheurapeutics
1.1.2.
Benzenesulphonamides
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Clorsulon | Clorsulon | Bovine | 50 μg/kg | Muscle | Provisional MRLs expire on 1 January 2000 |
150 μg/kg | Liver | ||||
400 μg/kg | Kidney |
1.2.
Antibiotics
1.2.1.
Beta-lactamase inhibitors
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Clavulanic acid | Clavulanic acid | Bovine, ovine | 200 μg/kg | Milk | Provisional MRLs expire on 1 July 1999 |
Bovine, ovine, porcine | 200 μg/kg | Muscle | |||
200 μg/kg | Fat | ||||
200 μg/kg | Liver | ||||
200 μg/kg | Kidney |
1.2.2.
Macrolides
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Erythromycin | MRLs apply to all microbiological active residues expressed as erythromycin equivalent | Bovine, ovine | 40 μg/kg | Milk | Provisional MRLs expire on 1 June 2000 |
Bovine, ovine, porcine, poultry | 400 μg/kg | Muscle | |||
400 μg/kg | Fat | ||||
400 μg/kg | Liver | ||||
400 μg/kg | Kidney | ||||
Poultry | 200 μg/kg | Eggs | |||
Josamycin | Josamycin | Chicken | 200 μg/kg | Muscle | Provisional MRLs expire on 1 July 2000 |
200 μg/kg | Fat | ||||
200 μg/kg | Liver | ||||
400 μg/kg | Kidney | ||||
200 μg/kg | Eggs |
1.2.5.
Aminoglycosides
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Aminosidine | Aminosidine | Bovine, porcine, rabbits, chicken | 500 μg/kg | Muscle | Provisional MRLs expire on 1 July 2000 |
1 500 μg/kg | Liver | ||||
1 500 μg/kg | Kidney | ||||
Apramycin | Apramycin | Bovine | 1 000 μg/kg | Muscle | Provisional MRLs expire on 1 July 1999 |
For use in non-lactating cattle only | 1 000 μg/kg | Fat | |||
10 000 μg/kg | Liver | ||||
20 000 μg/kg | Kidney | ||||
Porcine | 1 000 μg/kg | Muscle | |||
1 000 μg/kg | Skin and fat | ||||
1 000 μg/kg | Liver | ||||
5 000 μg/kg | Kidney | ||||
Dihydrostreptomycin | Dihydrostreptomycin | Bovine, ovine | 200 μg/kg | Milk | Provisional MRLs expire on 1 June 2000 |
Bovine, ovine, porcine, poultry | 500 μg/kg | Muscle | |||
500 μg/kg | Fat | ||||
500 μg/kg | Liver | ||||
1 000 μg/kg | Kidney | ||||
Gentamicin | Gentamicin | Bovine | 100 μg/kg | Milk | Provisional MRLs expire on 1 June 2000 |
Bovine, porcine | 100 μg/kg | Muscle | |||
100 μg/kg | Fat | ||||
200 μg/kg | Liver | ||||
1 000 μg/kg | Kidney | ||||
Neomycin (including framycetin) | Neomycin | Bovine, ovine, caprine | 500 μg/kg | Milk | Provisional MRLs expire on 1 June 2000 |
Bovine, ovine, caprine, porcine, chicken, turkey, duck | 500 μg/kg | Muscle | |||
500 μg/kg | Fat | ||||
500 μg/kg | Liver | ||||
5 000 μg/kg | Kidney | ||||
Chicken | 500 μg/kg | Eggs | |||
Spectinomycin | Spectinomycin | Bovine | 200 μg/kg | Milk | Provisional MRLs expire on 1 July 2000 |
Bovine, porcine, poultry | 300 μg/kg | Muscle | |||
500 μg/kg | Fat | ||||
2 000 μg/kg | Liver | ||||
5 000 μg/kg | Kidney | ||||
Streptomycin | Streptomycin | Bovine, ovine | 200 μg/kg | Milk | Provisional MRLs expire on 1 June 2000 |
Bovine, ovine, porcine, poultry | 500 μg/kg | Muscle | |||
500 μg/kg | Fat | ||||
500 μg/kg | Liver | ||||
1 000 μg/kg | Kidney |
1.2.6.
Quinolones
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Decoquinate | Decoquinate | Bovine, ovine | 500 μg/kg | Muscle | Provisional MRLs expire on 1 July 2000 |
500 μg/kg | Fat | ||||
500 μg/kg | Liver | ||||
500 μg/kg | Kidney | ||||
Enrofloxacin | Sum of enrofloxacin and ciprofloxacin | Ovine | 100 μg/kg | Muscle | Provisional MRLs expire on 1 July 1999 |
100 μg/kg | Fat | ||||
300 μg/kg | Liver | ||||
200 μg/kg | Kidney | ||||
Flumequine | Flumequine | Bovine, ovine, porcine, chicken | 50 μg/kg | Muscle | Provisional MRLs expire on 1 January 2000 |
50 μg/kg | Fat or skin and fat | ||||
100 μg/kg | Liver | ||||
300 μg/kg | Kidney | ||||
Salmonidae | 150 μg/kg | Muscle and skin | |||
Marbofloxacin | Marbofloxacin | Bovine | 150 μg/kg | Muscle | Provisional MRLs expire on 1 July 2000 |
50 μg/kg | Fat | ||||
150 μg/kg | Liver | ||||
150 μg/kg | Kidney | ||||
75 μg/kg | Milk | ||||
Porcine | 150 μg/kg | Muscle | |||
50 μg/kg | Skin and fat | ||||
150 μg/kg | Liver | ||||
150 μg/kg | Kidney |
1.2.9.
Polymyxins
Phamarcologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Colistin | Colistin | Bovine, ovine | 50 μg/kg | Milk | Provisional MRLs expire on 1 July 2000 |
Bovine, ovine, porcine, chicken, rabbits | 150 μg/kg | Muscle | |||
150 μg/kg | Fat | ||||
150 μg/kg | Liver | ||||
200 μg/kg | Kidney | ||||
Chicken | 300 μg/kg | Eggs |
1.2.10.
Penicillins
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Penethamate | Benzylpenicillin | Ovine | 50 μg/kg | Muscle | Provisional MRLs expire on 1 January 2000 |
50 μg/kg | Fat | ||||
50 μg/kg | Liver | ||||
50 μg/kg | Kidney | ||||
4 μg/kg | Milk | ||||
Porcine | 50 μg/kg | Muscle | |||
50 μg/kg | Fat | ||||
50 μg/kg | Liver | ||||
50 μg/kg | Kidney |
1.2.11.
Florfenicol and related compounds
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Florfenicol | Sum of florfenicol and its metabolites measured as florfenicol-amine | Fish | 1 000 μg/kg | Muscle and skin in natural proportions | Provisional MRLs expire on 1 July 2001 |
2.
Antiparasitic agents
2.1.
Agents acting against endoparasites
2.1.2.
Benzimidazoles and pro-benzimidazoles
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Albendazole sulphoxide | Sum of albendazole, albendazole sulphoxide, albendazole sulphone, and albendazole 2-amino sulphone, expressed as albendazole | Bovine, ovine | 100 μg/kg | Milk | Provisional MRLs expire on 1 January 2000 |
Bovine, ovine, pheasant | 100 μg/kg | Muscle | |||
100 μg/kg | Fat | ||||
1 000 μg/kg | Liver | ||||
500 μg/kg | Kidney | ||||
Netobimin | Sum of netobimin and albendazole and metabolites of albendazole measured as 2-amino- benzimidazole sulphone | Bovine, ovine, caprine | 100 μg/kg | Muscle | Provisional MRLs expire on 31 July 1999 |
100 μg/kg | Fat | ||||
1 000 μg/kg | Liver | ||||
500 μg/kg | Kidney | ||||
100 μg/kg | Milk |
2.2.
Agents acting against ectoparasites
2.2.1.
Formamidines
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Amitraz | Sum of amitraz and all metabolites containing the 2,4-DMA moeity, expressed as amitraz | Bees | 200 μg/kg | Honey | Provisional MRLs expire on 1 July 1999 |
2.2.2.
Iminophenyl thiazolidine derivative
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Cymiazole | Cymiazole | Bees | 1 000 μg/kg | Honey | Provisional MRLs expire on 1 July 1999 |
2.2.3.
Pyretrin and pyrethroids
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Cyfluthrin | Cyfluthrin | Bovine | 10 μg/kg | Muscle | Provisional MRLs expire on 1 January 2001 |
50 μg/kg | Fat | ||||
10 μg/kg | Liver | ||||
10 μg/kg | Kidney | ||||
20 μg/kg | Milk | ||||
Further provisions in Council Directive 94/29/EC are to be observed (OJ L 189, 23.7.1994, p. 67) |
2.2.4.
Organophosphates
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Azamethiphos | Azamethiphos | Salmonidae | 100 μg/kg | Muscle and skin in natural proportions | Provisional MRLs expire on 1 June 1999 |
2.2.5.
Acyl urea derivates
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Teflubenzuron | Teflubenzuron | Salmonidae | 500 μg/kg | Muscle and skin in natural proportions | Provisional MRLs expire on 1 July 1999 |
2.3.
Agents acting against endo- and ectoparasites
2.3.1.
Avermectins
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Moxidectin | Moxidectin | Equidae | 50 μg/kg | Muscle | Provisional MRLs expire on 1 January 2000 |
500 μg/kg | Fat | ||||
100 μg/kg | Liver | ||||
50 μg/kg | Kidney |
3.
Agents acting on the nervous system
3.2.
Agents acting on the autonomic nervous system
3.2.1.
β 2 sympathomimetic agents
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Clenbuterol hydrochloride | Clenbuterol | Bovine | 0,1 μg/kg | Muscle | Provisional MRLs expire on 1 July 2000 |
Indication: solely for tocolysis in parturient cows | 0,5 μg/kg | Liver | |||
0,5 μg/kg | Kidney | ||||
0,05 μg/kg | Milk | ||||
Equidae | 0,1 μg/kg | Muscle | |||
Indications: tocolysis and the treatment of respiratory ailments | 0,5 μg/kg | Liver | |||
0,5 μg/kg | Kidney |
5.
Anti-inflammatory agents
5.1.
Nonsteroidal anti-inflammatory agents
5.1.1.
Arylpropionic acid derivative
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Carprofen | Carprofen | Bovine | 500 μg/kg | Muscle | Provisional MRLs expire on 1 January 2000 |
500 μg/kg | Fat | ||||
1 000 μg/kg | Liver | ||||
1 000 μg/kg | Kidney | ||||
Equidae | 50 μg/kg | Muscle | |||
100 μg/kg | Fat | ||||
1 000 μg/kg | Liver | ||||
1 000 μg/kg | Kidney |
5.1.2.
Enolic acid derivates
Pharmacologically active substance(s) | Marker residue | Animal species | MRLs | Target tissues | Other provisions |
---|---|---|---|---|---|
Meloxicam | Meloxicam | Bovine | 25 μg/kg | Muscle | Provisional MRLs expire on 1 January 2000 |
60 μg/kg | Liver | ||||
35 μg/kg | Kidney |