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Regulation (EC) No 1272/2008 of the European Parliament and of the CouncilShow full title

Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (Text with EEA relevance)

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1.Part 1: Criteria for the selection of precautionary statementsU.K.

Table 6.1

Precautionary statements — General

CodeGeneral precautionary statementsHazard classHazard categoryConditions for use
(1)(2)(3)(4)(5)
P101If medical advice is needed, have product container or label at hand.as appropriateConsumer products
P102Keep out of reach of children.as appropriateConsumer products
[F1P103 Read carefully and follow all instructions. as appropriate Consumer products – omit where P202 is used]

Table 6.2

Precautionary statements — Prevention

CodePrevention precautionary statementsHazard classHazard categoryConditions for use
(1)(2)(3)(4)(5)
[F1P201 Obtain special instructions before use. Explosives (section 2.1) Unstable explosive
Germ cell mutagenicity (section 3.5) 1A,1B, 2 Consumer products – omit where P202 is used
Carcinogenicity (section 3.6) 1A,1B, 2
Reproductive toxicity (section 3.7) 1A,1B, 2
Reproductive toxicity — effects on or via lactation (section 3.7) Additional category
P202 Do not handle until all safety precautions have been read and understood. Flammable gases (section 2.2) A, B (chemically unstable gases)
Germ cell mutagenicity (section 3.5) 1A,1B, 2
Carcinogenicity (section 3.6) 1A,1B, 2
Reproductive toxicity (section 3.7) 1A,1B, 2
Reproductive toxicity, effects on or via lactation (section 3.7) Additional category ]
[F1P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Explosives (section 2.1) Divisions 1.1, 1.2, 1.3, 1.4, 1.5
Flammable gases (section 2.2) 1A, 1B, 2
Aerosols (section 2.3) 1, 2, 3
Flammable liquids (section 2.6) 1, 2, 3
Flammable solids (section 2.7) 1, 2
Self-reactive substances and mixtures (section 2.8) Types A, B, C, D, E, F
Pyrophoric liquids (section 2.9) 1
Pyrophoric solids (section 2.10) 1
Oxidising liquids (section 2.13) 1, 2, 3
Oxidising solids (section 2.14) 1, 2, 3
Organic peroxides (section 2.15) Types A, B, C, D, E, F
Desensitised explosives (section 2.17) 1, 2, 3, 4 ]
[F2P211 Do not spray on an open flame or other ignition source. Aerosols (section 2.3) 1, 2 ]
[F3P212 Avoid heating under confinement or reduction of the desensitising agent. Desensitised explosives (section 2.17) 1, 2, 3, 4 ]
[F4P220 Keep away from clothing and other combustible materials. Oxidising gases (Section 2.4) 1
Oxidising liquids (Section 2.13) 1, 2, 3
Oxidising solids (Section 2.14) 1, 2, 3]
[ F5
F5 ]
[F1P222 Do not allow contact with air. Flammable gases (section 2.2) Pyrophoric gas
  • if emphasis of the hazard statement is deemed necessary .

Pyrophoric liquids (section 2.9) 1
Pyrophoric solids (section 2.10) 1]
[F4P223 Do not allow contact with water. Substances and mixtures which, in contact with water, emit flammable gases (Section 2.12) 1, 2
if emphasis of the hazard statement is deemed necessary
[F1P230 Keep wetted with … Explosives (section 2.1) Divisions 1.1, 1.2, 1.3, 1.5

Manufacturer/supplier to specify appropriate material

  • for substances and mixtures which are wetted, diluted, dissolved or suspended with a phlegmatiser in order to suppress their explosive properties

Desensitised explosives (section 2.17) 1, 2, 3, 4 Manufacturer/supplier to specify appropriate material]
P231 Handle and store contents under inert gas/… Pyrophoric liquids (Section 2.9) 1 … Manufacturer/supplier to specify appropriate liquid or gas if inert gas is not appropriate.
Pyrophoric solids (Section 2.10) 1
Substances and mixtures which, in contact with water, emit flammable gases (Section 2.12) 1, 2, 3
if the substance or mixture reacts readily with moisture in air.

… Manufacturer/supplier to specify appropriate liquid or gas if inert gas is not appropriate.]

P232Protect from moisture.Substances and mixtures which, in contact with water, emit flammable gases (section 2.12)1, 2, 3
[F1P233 Keep container tightly closed. Flammable liquids (section 2.6) 1, 2, 3
  • if the liquid is volatile and may generate an explosive atmosphere

Pyrophoric liquids (section 2.9) 1
Pyrophoric solids (section 2.10) 1
Desensitised explosives (section 2.17) 1, 2, 3, 4
Acute toxicity – inhalation (section 3.1) 1, 2, 3
  • if the chemical is volatile and may generate a hazardous atmosphere

Specific target organ toxicity – single exposure; respiratory tract irritation (section 3.8) 3
Specific target organ toxicity – single exposure; narcotic effects (section 3.8) 3]
[F4P234 Keep only in original packaging. Explosives (Section 2.1) Divisions 1.1, 1.2, 1.3, 1.4, 1.5
Self-reactive substances and mixtures (Section 2.8) Types A, B, C, D, E, F
Organic peroxides (Section 2.15) Types A, B, C, D, E, F
Corrosive to metals (Section 2.16) 1
P235 Keep cool. Flammable liquids (Section 2.6) 1, 2, 3
for flammable liquids category 1 and other flammable liquids that are volatile and may generate an explosive atmosphere
Self-reactive substances and mixtures (Section 2.8) Types A, B, C, D, E, F
may be omitted if P411 is given on the label
Self-heating substances and mixtures (Section 2.11) 1, 2
may be omitted if P413 is given on the label
Organic peroxides (Section 2.15) Types A, B, C, D, E, F
may be omitted if P411 is given on the label
P240 Ground and bond container and receiving equipment. Explosives (Section 2.1) Divisions 1.1, 1.2, 1.3, 1.4, 1.5
if the explosive is electrostatically sensitive
Flammable liquids (Section 2.6) 1, 2, 3
if the liquid is volatile and may generate an explosive atmosphere
Flammable solids (Section 2.7) 1, 2
if the solid is electrostatically sensitive
Self-reactive substances and mixtures (Section 2.8) Types A,B,C, D, E, F
if electrostatically sensitive and able to generate an explosive atmosphere
Organic peroxides (Section 2.15)
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. Flammable liquids (Section 2.6) 1, 2, 3
  • if the liquid is volatile and may generate an explosive atmosphere.

  • text in square brackets may be used to specify specific electrical, ventilating, lighting or other equipment if necessary and as appropriate.

Flammable solids (Section 2.7) 1, 2
  • if dust clouds can occur.

  • text in square brackets may be used to specify specific electrical, ventilating, lighting or other equipment if necessary and as appropriate.

P242 Use non-sparking tools. Flammable liquids (Section 2.6) 1, 2, 3
if the liquid is volatile and may generate an explosive atmosphere and if the minimum ignition energy is very low. (This applies to substances and mixtures where the ignition energy is < 0,1 mJ, e.g. carbon disulphide).
P243 Take action to prevent static discharges. Flammable liquids (Section 2.6) 1, 2, 3
if the liquid is volatile and may generate an explosive atmosphere.]
[F2P244 Keep valves and fittings free from oil and grease. Oxidising gases (section 2.4) 1 ]
[F4P250 Do not subject to grinding/shock/friction … Explosives (Section 2.1) Unstable explosives and divisions 1.1, 1.2, 1.3, 1.4, 1.5
if the explosive is mechanically sensitive

… Manufacturer/supplier to specify applicable rough handling.]

[F2P251 Do not pierce or burn, even after use. Aerosols (section 2.3) 1, 2, 3 ]
P260Do not breathe dust/fume/gas/mist/vapours/spray.Acute toxicity — inhalation (section 3.1)1, 2Manufacturer/supplier to specify applicable conditions.
Specific target organ toxicity — single exposure (section 3.8)1, 2
Specific target organ toxicity — repeated exposure (section 3.9)1, 2
Skin corrosion (section 3.2)1A, 1B, 1C
  • Specify do not breathe dusts or mists.

  • if inhalable particles of dusts or mists may occur during use.

Reproductive toxicity — effects on or via lactation (section 3.7)Additional category
[F4P261 Avoid breathing dust/fume/gas/mist/vapours/spray. Acute toxicity — inhalation (Section 3.1) 3, 4
may be omitted if P260 is given on the label

Manufacturer/supplier to specify applicable conditions.

Respiratory sensitisation (Section 3.4) 1, 1A, 1B
Skin sensitisation (Section 3.4) 1, 1A, 1B
Specific target organ toxicity — single exposure; respiratory tract irritation (Section 3.8) 3
Specific target organ toxicity — single exposure; narcotic effects (Section 3.8) 3]
P262Do not get in eyes, on skin, or on clothing.Acute toxicity — dermal (section 3.1)1, 2
[F4P263 Avoid contact during pregnancy and while nursing. Reproductive toxicity — effects on or via lactation (Section 3.7) Additional category ]
P264Wash … thoroughly after handling.Acute toxicity — oral (section 3.1)1, 2, 3, 4Manufacturer/supplier to specify parts of the body to be washed after handling.
Acute toxicity — dermal (section 3.1)1, 2
Skin corrosion (section 3.2)1A, 1B, 1C
Skin irritation (section 3.2)2
Eye irritation (section 3.3)2
Reproductive toxicity — effects on or via lactation (section 3.7)Additional category
Specific target organ toxicity — single exposure (section 3.8)1, 2
Specific target organ toxicity — repeated exposure (section 3.9)1
P270Do not eat, drink or smoke when using this product.Acute toxicity — oral (section 3.1)1, 2, 3, 4
Acute toxicity — dermal (section 3.1)1, 2
Reproductive toxicity — effects on or via lactation (section 3.7)Additional category
Specific target organ toxicity — single exposure (section 3.8)1, 2
Specific target organ toxicity — repeated exposure (section 3.9)1
P271Use only outdoors or in a well-ventilated area.Acute toxicity — inhalation (section 3.1)1, 2, 3, 4
Specific target organ toxicity — single exposure; respiratory tract irritation (section 3.8)3
Specific target organ toxicity — single exposure; narcosis (section 3.8)3
[F6P272 Contaminated work clothing should not be allowed out of the workplace. Skin sensitisation (section 3.4) 1, 1A, 1B ]
P273Avoid release to the environment.Hazardous to the aquatic environment — acute aquatic hazard (section 4.1)1
  • if this is not the intended use.

Hazardous to the aquatic environment — [F6long-term aquatic hazard (section 4.1)]1, 2, 3, 4
[ F7 ]
[F1P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/… Explosives (section 2.1) Unstable explosive and divisions 1.1, 1.2, 1.3, 1.4, 1.5 Manufacturer/supplier to specify the appropriate type of personal protective equipment.
Flammable gases (section 2.2) Pyrophoric gas
Flammable liquids (section 2.6) 1, 2, 3
Flammable solids (section 2.7) 1, 2
Self-reactive substances and mixtures (section 2.8) Types A, B, C, D, E, F
Pyrophoric liquids (section 2.9) 1
Pyrophoric solids (section 2.10) 1
Self-heating substances and mixtures (section 2.11) 1, 2
Substances and mixtures which, in contact with water, emit flammable gases (section 2.12) 1, 2, 3
Oxidizing liquids (section 2.13) 1, 2, 3
Oxidizing solids (section 2.14) 1, 2, 3
Organic peroxides (section 2.15) Types A, B, C, D, E, F
Desensitised explosives (section 2.17) 1, 2, 3, 4
Acute toxicity – dermal (section 3.1) 1, 2, 3, 4
  • Specify protective gloves/clothing.

Manufacturer/supplier may further specify type of equipment where appropriate.

Skin corrosion (section 3.2) 1A, 1B, 1C
  • Specify protective gloves/clothing and eye/face protection.

Manufacturer/supplier may further specify type of equipment where appropriate.

Skin irritation (section 3.2) 2
  • Specify protective gloves.

Manufacturer/supplier may further specify type of equipment where appropriate.

Skin sensitisation (section 3.4) 1, 1A, 1B
Serious eye damage (section 3.3) 1
  • Specify eye/face protection.

Manufacturer/supplier may further specify type of equipment where appropriate.

Eye irritation (section 3.3) 2
Germ cell mutagenicity (section 3.5) 1A, 1B, 2 Manufacturer/supplier to specify the appropriate type of personal protective equipment.
Carcinogenicity (section 3.6) 1A, 1B, 2
Reproductive toxicity (section 3.7) 1A, 1B, 2]
[ F8
F8
F8
F8 ]
[F4P282 Wear cold insulating gloves and either face shield or eye protection. Gases under pressure (Section 2.5) Refrigerated liquefied gas
P283 Wear fire resistant or flame retardant clothing. Oxidising liquids (Section 2.13) 1
Oxidising solids (Section 2.14) 1
P284 [In case of inadequate ventilation] wear respiratory protection. Acute toxicity — inhalation (Section 3.1) 1, 2
text in square brackets may be used if additional information is provided with the chemical at the point of use that explains what type of ventilation would be adequate for safe use.

Manufacturer/supplier to specify equipment.

Respiratory sensitisation (Section 3.4) 1, 1A, 1B]
[ F8 ]
[F4P231 + P232

Handle and store contents under inert gas/…

Protect from moisture.

Pyrophoric liquids (Section 2.9) 1 … Manufacturer/supplier to specify the appropriate liquid or gas if inert gas is not appropriate.
Pyrophoric solids (Section 2.10) 1
Substances and mixtures which, in contact with water, emit flammable gases (Section 2.12) 1, 2, 3
if the substance or mixture reacts readily with moisture in air.

… Manufacturer/supplier to specify appropriate liquid or gas if inert gas is not appropriate.]

[ F5 ]

Textual Amendments

Table 6.3

Precautionary statements — Response

CodeResponse precautionary statementsHazard classHazard categoryConditions for use
(1)(2)(3)(4)(5)
[F1P301 IF SWALLOWED: Acute toxicity – oral (section 3.1) 1, 2, 3, 4
Skin corrosion (section 3.2) 1, 1A, 1B, 1C
Aspiration Hazard (section 3.10) 1
P302 IF ON SKIN: Pyrophoric liquids (section 2.9) 1
Pyrophoric solids (section 2.10) 1
Substances and mixtures which, in contact with water, emit flammable gases (section 2.12) 1, 2
Acute toxicity – dermal (section 3.1) 1, 2, 3, 4
Skin irritation (section 3.2) 2
Skin sensitisation (section 3.4) 1, 1A, 1B]
P303IF ON SKIN (or hair):Flammable liquids (section 2.6)1, 2, 3
Skin corrosion (section 3.2)1A, 1B, 1C
[F6P304 IF INHALED: Acute toxicity — inhalation (section 3.1) 1, 2, 3, 4
Skin corrosion (section 3.2) 1A, 1B, 1C
Respiratory sensitisation (section 3.4) 1, 1A, 1B
Specific target organ toxicity — single exposure; respiratory tract irritation (section 3.8) 3
Specific target organ toxicity — single exposure; narcosis (section 3.8) 3]
P305IF IN EYES:Skin corrosion (section 3.2)1A, 1B, 1C
Serious eye damage/eye irritation (section 3.3)1
Eye irritation (section 3.3)2
P306IF ON CLOTHING:Oxidising liquids (section 2.13)1
Oxidising solids (section 2.14)1
[ F8 ]
[F2P308 IF exposed or concerned: Germ cell mutagenicity (section 3.5) 1A, 1B, 2
Carcinogenicity (section 3.6) 1A, 1B, 2
Reproductive toxicity (section 3.7) 1A, 1B, 2
Reproductive toxicity — effects on or via lactation (section 3.7) Additional category
Specific target organ toxicity, single exposure (section 3.8) 1, 2]
[ F8 ]
[F2P310 Immediately call a POISON CENTER/doctor/… Acute toxicity — oral (section 3.1) 1, 2, 3 …Manufacturer/supplier to specify the appropriate source of emergency medical advice.
Acute toxicity — dermal (section 3.1) 1, 2
Acute toxicity — inhalation (section 3.1) 1, 2
Skin corrosion (section 3.2) 1A, 1B, 1C
Serious eye damage/eye irritation (section 3.3) 1
Aspiration hazard (section 3.10) 1
P311 Call a POISON CENTER/doctor/… Acute toxicity — inhalation (section 3.1) 3 …Manufacturer/supplier to specify the appropriate source of emergency medical advice.
Respiratory sensitisation (section 3.4) 1, 1A, 1B
Specific target organ toxicity — single exposure (section 3.8) 1, 2
[F4P312 Call a POISON CENTRE/doctor/… if you feel unwell. Acute toxicity — oral (Section 3.1) 4 … Manufacturer/supplier to specify the appropriate source of emergency medical advice.
Acute toxicity — dermal (Section 3.1) 3, 4
Acute toxicity — inhalation (Section 3.1) 4
Specific target organ toxicity — single exposure; respiratory tract irritation (Section 3.8) 3
Specific target organ toxicity — single exposure; narcotic effects (Section 3.8) 3] ]
[F6P313 Get medical advice/attention. Skin irritation (section 3.2) 2, 3
Eye irritation (section 3.3) 2
Skin sensitisation (section 3.4) 1, 1A, 1B
Germ cell mutagenicity (section 3.5) 1A, 1B, 2
Carcinogenicity (section 3.6) 1A, 1B, 2
Reproductive toxicity (section 3.7) 1A, 1B, 2
Reproductive toxicity — effects on or via lactation (section 3.7) Additional category]
P314Get medical advice/attention if you feel unwell.Specific target organ toxicity — repeated exposure (section 3.9)1, 2
P315Get immediate medical advice/attention.Gases under pressure (section 2.5)Refrigerated liquefied gas
[F4P320 Specific treatment is urgent (see … on this label). Acute toxicity — inhalation (Section 3.1) 1, 2
if immediate administration of antidote is required.

… Reference to supplemental first aid instruction.

P321 Specific treatment (see … on this label). Acute toxicity — oral (Section 3.1) 1, 2, 3
if immediate administration of antidote is required.

… Reference to supplemental first aid instruction.

Acute toxicity, dermal (Section 3.1) 1, 2, 3, 4
if immediate measures such as specific cleansing agent are advised.

… Reference to supplemental first aid instruction.

Acute toxicity — inhalation (Section 3.1) 3
if immediate specific measures are required.

… Reference to supplemental first aid instruction.

Skin corrosion (Section 3.2) 1, 1A, 1B, 1C

… Reference to supplemental first aid instruction.

Manufacturer/supplier may specify a cleansing agent if appropriate.

Skin irritation (Section 3.2) 2
Skin sensitisation (Section 3.4) 1, 1A, 1B
Specific target organ toxicity — single exposure (Section 3.8) 1
if immediate measures are required.

… Reference to supplemental first aid instruction.]

[ F8
F8 ]
P330Rinse mouth.Acute toxicity — oral (section 3.1)1, 2, 3, 4
Skin corrosion (section 3.2)1A, 1B, 1C
P331Do NOT induce vomiting.Skin corrosion (section 3.2)1A, 1B, 1C
Aspiration hazard (section 3.10)1
[F1P332 If skin irritation occurs: Skin irritation (section 3.2) 2 may be omitted if P333 is given on the label.]
[F6P333 If skin irritation or rash occurs: Skin sensitisation (section 3.4) 1, 1A, 1B ]
[F4P334 Immerse in cool water [or wrap in wet bandages]. Pyrophoric liquids (Section 2.9) 1
text in square brackets to be used for pyrophoric liquids and solids
Pyrophoric solids (Section 2.10) 1
Substances and mixtures which, in contact with water, emit flammable gases (Section 2.12) 1, 2 Use only immerse in cool water. Text in square brackets should not be used.]
P335Brush off loose particles from skin.Pyrophoric solids (section 2.10)1
Substances and mixtures which, in contact with water, emit flammable gases (section 2.12)1, 2
P336Thaw frosted parts with lukewarm water. Do not rub affected area.Gases under pressure (section 2.5)Refrigerated liquefied gas
P337If eye irritation persists:Eye irritation (section 3.3)2
P338Remove contact lenses, if present and easy to do. Continue rinsing.Skin corrosion (section 3.2)1A, 1B, 1C
Serious eye damage/eye irritation (section 3.3)1
Eye irritation (section 3.3)2
[F2P340 Remove person to fresh air and keep comfortable for breathing. Acute toxicity — inhalation (section 3.1) 1, 2, 3, 4
Skin corrosion (section 3.2) 1A, 1B, 1C
Respiratory sensitisation (section 3.4) 1, 1A, 1B
Specific target organ toxicity — single exposure; respiratory tract irritation (section 3.8) 3
Specific target organ toxicity — single exposure; narcosis (section 3.8) 3]
[ F8 ]
[F6P342 If experiencing respiratory symptoms: Respiratory sensitisation (section 3.4) 1, 1A, 1B ]
[ F8 ]
P351Rinse cautiously with water for several minutes.Skin corrosion (section 3.2)1A, 1B, 1C
Serious eye damage/eye irritation (section 3.3)1
Eye irritation (section 3.3)2
[F2P352 Wash with plenty of water/… Acute toxicity — dermal (section 3.1) 1, 2, 3, 4 …Manufacturer/supplier may specify a cleansing agent if appropriate, or may recommend an alternative agent in exceptional cases if water is clearly inappropriate.
Skin irritation (section 3.2) 2
Skin sensitisation (section 3.4) 1, 1A, 1B]
[F4P353 Rinse skin with water [or shower]. Flammable liquids (Section 2.6) 1, 2, 3
text in square brackets to be included where the manufacturer/supplier considers it appropriate for the specific chemical.
Skin corrosion (Section 3.2) 1, 1A, 1B, 1C]
P360Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.Oxidising liquids (section 2.13)1
Oxidising solids (section 2.14)1
[F2P361 Take off immediately all contaminated clothing. Flammable liquids (section 2.6) 1, 2, 3
Acute toxicity — dermal (section 3.1) 1, 2, 3
Skin corrosion (section 3.2) 1A, 1B, 1C
P362 Take off contaminated clothing. Acute toxicity, dermal (section 3.1) 4
Skin irritation (section 3.2) 2
Skin sensitisation (section 3.4) 1, 1A, 1B
P363 Wash contaminated clothing before reuse. Skin corrosion (section 3.2) 1A, 1B, 1C ]
[F9P364 And wash it before reuse. Acute toxicity, dermal (section 3.1) 1, 2, 3, 4
Skin irritation (section 3.2) 2
Skin sensitisation (section 3.4) 1, 1A, 1B ]
[F1P370 In case of fire: Explosives (section 2.1) Unstable explosives and divisions 1.1, 1.2, 1.3, 1.4, 1.5
Oxidising gases (section 2.4) 1
Flammable liquids (section 2.6) 1, 2, 3
Flammable solids (section 2.7) 1, 2
Self-reactive substances and mixtures (section 2.8) Types A, B, C, D, E, F
Pyrophoric liquids (section 2.9) 1
Pyrophoric solids (section 2.10) 1
Substances and mixtures which, in contact with water, emit flammable gases (section 2.12) 1, 2, 3
Oxidising liquids (section 2.13) 1, 2, 3
Oxidising solids (section 2.14) 1, 2, 3
Organic Peroxides (section 2.15) Types A, B, C, D, E, F
Desensitised explosives (section 2.17) 1, 2, 3
P371 In case of major fire and large quantities: Oxidising liquids (section 2.13) 1
Oxidising solids (section 2.14) 1
Desensitised explosives (section 2.17) 4 ]
[F4P372 Explosion risk. Explosives (Section 2.1) Unstable explosives and Divisions 1.1, 1.2, 1.3, and 1.5
Division 1.4
except for explosives of division 1.4 (compatibility group S) in transport packaging.
Self-reactive substances and mixtures (Section 2.8) Type A
Organic peroxides (Section 2.15) Type A
P373 DO NOT fight fire when fire reaches explosives. Explosives (Section 2.1) Unstable explosives and Divisions 1.1, 1.2, 1.3, 1.5
Division 1.4
except for explosives of division 1.4 (compatibility group S) in transport packaging.
Self-reactive substances and mixtures (Section 2.8) Type A
Organic peroxides (Section 2.15) Type A]
[ F5 ]
[F1P375 Fight fire remotely due to the risk of explosion. Explosives (section 2.1) Division 1.4
  • for explosives of division 1.4 (compatibility group S) in transport packaging.

Self-reactive substances and mixtures (section 2.8) Type B
Oxidising liquids (section 2.13) 1
Oxidising solids (section 2.14) 1
Organic peroxides (section 2.15) Type B
Desensitised explosives (section 2.17) 1, 2, 3, 4]
P376Stop leak if safe to do so.Oxidising gases (section 2.4)1
[F1P377 Leaking gas fire: Do not extinguish, unless leak can be stopped safely. Flammable gases (section 2.2) 1A, 1B, 2 ]
[F4P378 Use … to extinguish. Flammable liquids (Section 2.6) 1, 2, 3
if water increases risk

… Manufacturer/supplier to specify appropriate media

Flammable solids (Section 2.7) 1, 2
Self-reactive substances and mixtures (Section 2.8) Types B, C, D, E, F
Pyrophoric liquids (Section 2.9) 1
Pyrophoric solids (Section 2.10) 1
Substances and mixtures which, in contact with water, emit flammable gases (Section 2.12) 1, 2, 3
Oxidising liquids (Section 2.13) 1, 2, 3
Oxidising solids (Section 2.14) 1, 2, 3
Organic peroxides (Section 2.15) Types B, C, D, E, F
[F1P380 Evacuate area. Explosives (section 2.1) Unstable explosives and Divisions 1.1, 1.2, 1.3, 1.4, 1.5
Self-reactive substances and mixtures (section 2.8) Types A, B
Oxidising liquids (section 2.13) 1
Oxidising solids (section 2.14) 1
Organic peroxides (section 2.15) Types A, B
Desensitised explosives (section 2.17) 1, 2, 3, 4 ]
[F1P381 In case of leakage, eliminate all ignition sources Flammable gases (section 2.2) 1A, 1B, 2 ] ]
P390Absorb spillage to prevent material damage.Corrosive to metals (section 2.16)1
P391Collect spillage.Hazardous to the aquatic environment – acute aquatic hazard (section 4.1)1
Hazardous to the aquatic environment – [F6long-term aquatic hazard (section 4.1)]1, 2
[F2P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… Acute toxicity — oral (section 3.1) 1, 2, 3 …Manufacturer/supplier to specify the appropriate source of emergency medical advice.
Aspiration hazard (section 3.10) 1
[F1P301 + P312 IF SWALLOWED: Call a POISON CENTER/doctor/… if you feel unwell Acute toxicity – oral (section 3.1) 4 … Manufacturer/supplier to specify the appropriate source of emergency medical advice] ]
[ F5 ]
[F4P302 + P334 IF ON SKIN: Immerse in cool water or wrap in wet bandages. Pyrophoric liquids (Section 2.9) 1 ]
[ F8 ]
[F2P302 + P352 IF ON SKIN: Wash with plenty of water/… Acute toxicity — dermal (section 3.1) 1, 2, 3, 4 …Manufacturer/supplier may specify a cleansing agent if appropriate, or may recommend an alternative agent in exceptional cases if water is clearly inappropriate.
Skin irritation (section 3.2) 2
Skin sensitisation (section 3.4) 1, 1A, 1B]
[ F5
F5 ]
[F2P304 + P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Acute toxicity — inhalation (section 3.1) 1, 2, 3, 4
Skin corrosion (section 3.2) 1A, 1B, 1C
Respiratory sensitisation (section 3.4) 1, 1A, 1B
Specific target organ toxicity — single exposure; respiratory tract irritation (section 3.8) 3
Specific target organ toxicity — single exposure; narcosis (section 3.8) 3]
[ F8 ]
[ F5
F5
F5 ]
P306 + P360IF ON CLOTHING: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.Oxidising liquids (section 2.13)1
Oxidising solids (section 2.14)1
[F2P308 + P311 IF exposed or concerned: Call a POISON CENTER/doctor/… Specific target organ toxicity — single exposure (section 3.8) 1, 2 …Manufacturer/supplier to specify the appropriate source of emergency medical advice.]
P308 + P313IF exposed or concerned: Get medical advice/attention.Germ cell mutagenicity (section 3.5)1A, 1B, 2
Carcinogenicity (section 3.6)1A, 1B, 2
Reproductive toxicity (section 3.7)1A, 1B, 2
Reproductive toxicity — effects on or via lactation (section 3.7)Additional category
[ F8 ]
[F4P332 + P313 If skin irritation occurs: Get medical advice/attention. Skin irritation (Section 3.2) 2
may be omitted when P333 + P313 is given on the label.]
[F6P333 + P313 If skin irritation or rash occurs: Get medical advice/attention. Skin sensitisation (section 3.4) 1, 1A, 1B ]
[F10P336 + P315 Thaw frosted parts with lukewarm water. Do not rub affected area. Get immediate medical advice/attention. Gases under pressure (Section 2.5) Refrigerated liquefied gas ]
[ F5
F5 ]
P337 + P313If eye irritation persists: Get medical advice/attention.Eye irritation (section 3.3)2
[F2P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/… Respiratory sensitisation (section 3.4) 1, 1A, 1B …Manufacturer/supplier to specify the appropriate source of emergency medical advice.]
[F9P361 + P364 Take off immediately all contaminated clothing and wash it before reuse. Acute toxicity, dermal (section 3.1) 1, 2, 3
P362 + P364 Take off contaminated clothing and wash it before reuse. Acute toxicity, dermal (section 3.1) 4
Skin irritation (section 3.2) 2
Skin sensitisation (section 3.4) 1, 1A, 1B]
P370 + P376In case of fire: Stop leak if safe to do so.Oxidizing gases (section 2.4)1
[F4P370 + P378 In case of fire: Use … to extinguish. Flammable liquids (Section 2.6) 1, 2, 3
if water increases risk.

… Manufacturer/sup-plier to specify appropriate media.

Flammable solids (Section 2.7) 1, 2
Self-reactive substances and mixtures (Section 2.8) Types C, D, E, F
Pyrophoric liquids (Section 2.9) 1
Pyrophoric solids (Section 2.10) 1
Substances and mixtures which, in contact with water, emit flammable gases (Section 2.12) 1, 2, 3
Oxidising liquids (Section 2.13) 1, 2, 3
Oxidising solids (Section 2.14) 1, 2, 3
Organic peroxides (Section 2.15) Types C, D, E, F]
[F10P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Skin corrosion (Section 3.2) 1, 1A, 1B, 1C
P302 + P335 + P334 IF ON SKIN: Brush off loose particles from skin. Immerse in cool water [or wrap in wet bandages]. Pyrophoric solids (Section 2.10) 1
text in square brackets to be used for pyrophoric solids
Substances and mixtures which, in contact with water, emit flammable gases (Section 2.12) 1, 2
use only Immerse in cold water . Text in square brackets should not be used.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. Flammable liquids (Section 2.6) 1, 2, 3
text in square brackets to be included where the manufacturer/supplier considers it appropriate for the specific chemical.
Skin corrosion (Section 3.2) 1, 1A, 1B, 1C
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Skin corrosion (Section 3.2) 1, 1A, 1B, 1C
Serious eye damage/eye irritation (Section 3.3) 1
Eye irritation (Section 3.3) 2 ]
[ F5 ]
[F1P370 + P380 + P375 In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. Explosives (section 2.1) Division 1.4
  • for explosives of division 1.4 (compatibility group S) in transport packaging

Desensitised explosives (section 2.17) 1, 2, 3
P371 + P380 + P375 In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. Oxidising liquids (section 2.13) 1
Oxidising solids (section 2.14) 1
Desensitised explosives (section 2.17) 4]
[F10P370 + P372 + P380 + P373 In case of fire: Explosion risk. Evacuate area. DO NOT fight fire when fire reaches explosives Explosives (Section 2.1) Unstable explosives and divisions 1.1, 1.2, 1.3, 1.5
Division 1.4
except for explosives of division 1.4 (compatibility group S) in transport packaging.
Self-reactive substances and mixtures (Section 2.8) Type A
Organic peroxides (Section 2.15) Type A
P370 + P380 + P375 + [P378] In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. [Use … to extinguish]. Self-reactive substances and mixtures (Section 2.8) Type B
text in square brackets to be used if water increases risk.

… Manufacturer/supplier to specify appropriate media.

Organic peroxides (Section 2.15) Type B]

Table 6.4

Precautionary statements — Storage

CodeStorage precautionary statementsHazard classHazard categoryConditions for use
(1)(2)(3)(4)(5)
[F1P401 Store in accordance with … Explosives (section 2.1) Unstable explosives and Divisions 1.1, 1.2, 1.3, 1.4, 1.5 … Manufacturer/supplier to specify local/regional/national/international regulations as applicable.
Desensitised explosives (section 2.17) 1, 2, 3, 4]
P402Store in a dry place.Substances and mixtures which, in contact with water, emit flammable gases (section 2.12)1, 2, 3
[F1P403 Store in a well-ventilated place. Flammable gases (section 2.2) 1A, 1B, 2
Oxidising gases (section 2.4) 1
Gases under pressure (section 2.5) Compressed gas
Liquefied gas
Refrigerated liquefied gas
Dissolved gas
Flammable liquids (section 2.6) 1, 2, 3
  • for flammable liquids Category 1 and other flammable liquids that are volatile and may generate an explosive atmosphere.

Self-reactive substances and mixtures (section 2.8) Types A, B, C, D, E, F
  • except for temperature controlled self-reactive substances and mixtures or organic peroxides because condensation and consequent freezing may take place.

Organic peroxides (section 2.15)
Acute toxicity – inhalation (section 3.1) 1, 2, 3
  • if the substance or mixture is volatile and may generate a hazardous atmosphere.

Specific target organ toxicity – single exposure; respiratory tract irritation (section 3.8) 3
Specific target organ toxicity – single exposure; narcotic effects (section 3.8) 3]
P404Store in a closed container.Substances and mixtures which, in contact with water, emit flammable gases (section 2.12)1, 2, 3
P405Store locked up.Acute toxicity — oral (section 3.1)1, 2, 3
Acute toxicity — dermal (section 3.1)1, 2, 3
Acute toxicity — inhalation (section 3.1)1, 2, 3
Skin corrosion (section 3.2)1A, 1B, 1C
Germ cell mutagenicity (section 3.5)1A, 1B, 2
Carcinogenicity (section 3.6)1A, 1B, 2
Reproductive toxicity (section 3.7)1A, 1B, 2
Specific target organ toxicity — single exposure (section 3.8)1, 2
Specific target organ toxicity — single exposure; respiratory tract irritation (section 3.8)3
Specific target organ toxicity — single exposure; narcosis (section 3.8)3
Aspiration hazard (section 3.10)1
[F4P406 Store in a corrosion-resistant/… container with a resistant inner liner. Corrosive to metals (Section 2.16) 1
may be omitted if P234 is given on the label

… Manufacturer/supplier to specify other compatible materials.]

[F4P407 Maintain air gap between stacks or pallets. Self-heating substances and mixtures (Section 2.11) 1, 2 ]
[F2P410 Protect from sunlight. Aerosols (section 2.3) 1,2, 3
Gases under pressure (section 2.5)

Compressed gas

Liquefied gas

Dissolved gas

may be omitted for gases filled in transportable gas cylinders in accordance with packing instruction P200 of the UN RTDG, Model Regulations, unless those gases are subject to (slow) decomposition or polymerisation
Self-heating substances and mixtures (section 2.11) 1, 2
Organic peroxides (section 2.15) Types A, B, C, D, E, F ]
[F4P411 Store at temperatures not exceeding … °C/… °F. Self-reactive substances and mixtures (Section 2.8) Types A, B, C, D, E, F
if temperature control is required (according to Annex I, Section 2.8.2.4 or 2.15.2.3) or if otherwise deemed necessary.

… Manufacturer/supplier to specify temperature using the applicable temperature scale.

Organic peroxides (Section 2.15) Types A, B, C, D, E, F
P412 Do not expose to temperatures exceeding 50 °C/ 122 °F. Aerosols (Section 2.3) 1, 2, 3 Manufacturer/supplier to use applicable temperature scale.
P413 Store bulk masses greater than … kg/… lbs at temperatures not exceeding … °C/… °F. Self-heating substances and mixtures (Section 2.11) 1, 2 … Manufacturer/supplier to specify mass and temperature using applicable scale.
P420 Store separately. Self-reactive substances and mixtures (Section 2.8) Types A, B, C, D, E, F
Self-heating substances and mixtures (Section 2.11) 1,2
Oxidising liquids (Section 2.13) 1
Oxidising solids (Section 2.14) 1
Organic peroxides (Section 2.15) Types A,B,C,D,E,F]
[ F5
F5 ]
P402 + P404Store in a dry place. Store in a closed container.Substances and mixtures which, in contact with water, emit flammable gases (section 2.12)1, 2, 3
[F4P403 + P233 Store in a well-ventilated place. Keep container tightly closed. Acute toxicity — inhalation (Section 3.1) 1, 2, 3
if the substance or mixture is volatile and may generate a hazardous atmosphere.
Specific target organ toxicity — single exposure; respiratory tract irritation (Section 3.8) 3
Specific target organ toxicity — single exposure; narcosis (Section 3.8) 3
P403 + P235 Store in a well-ventilated place. Keep cool. Flammable liquids (Section 2.6) 1, 2, 3
for flammable liquids Category 1 and other flammable liquids that are volatile and may generate an explosive atmosphere.
P410 + P403 Protect from sunlight. Store in a well-ventilated place. Gases under pressure (Section 2.5) Compressed gas
P410 may be omitted for gases filled in transportable gas cylinders in accordance with packing instruction P200 of the UN RTDG, unless those gases are subject to (slow) decomposition or polymerisation.
Liquefied gas
Dissolved gas
P410 + P412 Protect from sunlight. Do not expose to temperatures exceeding 50 °C/122 °F. Aerosols (Section 2.3) 1, 2, 3 Manufacturer/ supplier to use applicable temperature scale.]
[ F5 ]

[F6Table 6.5

Precautionary statements — Disposal

Code Disposal precautionary statements Hazard class Hazard category Conditions for use
(1) (2) (3) (4) (5)
[F1P501 Dispose of contents/container to … Flammable liquids (section 2.6) 1, 2, 3

… in accordance with local/regional/national/international regulation (to be specified).

Manufacturer/supplier to specify whether disposal requirements apply to contents, container or both.

Self-reactive substances and mixtures (section 2.8) Types A, B, C, D, E, F
Substances and mixtures which, in contact with water, emit flammable gases (section 2.12) 1, 2, 3
Oxidising liquids (section 2.13) 1, 2, 3
Oxidising solids (section 2.14) 1, 2, 3
Organic peroxides (section 2.15) Types A, B, C, D, E, F
Desensitised explosives (section 2.17) 1, 2, 3, 4
Acute toxicity – oral (section 3.1) 1, 2, 3, 4
Acute toxicity – dermal (section 3.1) 1, 2, 3, 4
Acute toxicity – inhalation (section 3.1) 1, 2, 3
Skin corrosion (section 3.2) 1, 1A, 1B, 1C
Respiratory sensitisation (section 3.4) 1, 1A, 1B
Skin sensitisation (section 3.4) 1, 1A, 1B
Germ cell mutagenicity (section 3.5) 1A, 1B, 2
Carcinogenicity (section 3.6) 1A, 1B, 2
Reproductive toxicity (section 3.7) 1A, 1B, 2
Specific target organ toxicity – single exposure (section 3.8) 1, 2
Specific target organ toxicity – single exposure; respiratory tract irritation (section 3.8) 3
Specific target organ toxicity – single exposure; narcotic effects (section 3.8) 3
Specific target organ toxicity – repeated exposure (section 3.9) 1, 2
Aspiration hazard (section 3.10) 1
Hazardous to the aquatic environment – acute aquatic hazard (section 4.1) 1
Hazardous to the aquatic environment – chronic aquatic hazard (section 4.1) 1, 2, 3, 4]
[F4P502 Refer to manufacturer or supplier for information on recovery or recycling Hazardous to the ozone layer (Section 5.1) 1 ]
[F3P503 Refer to manufacturer/ supplier/… for information on disposal/recovery/ recycling Explosives (section 2.1) Unstable explosives and Divisions 1.1, 1.2, 1.3, 1.4, 1.5 … Manufacturer/supplier to specify appropriate source of information in accordance with local/regional/national/international regulations as applicable.] ]

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