E 1205 BASIC METHACRYLATE COPOLYMER
| Synonyms | Basic butylated methacrylate copolymer; amino methacrylate copolymer; aminoalkyl methacrylate copolymer E; butyl methacrylate, dimethylaminoethyl methacrylate, methyl methacrylate polymer; butyl methacrylate, methyl methacrylate, dimethylaminoethyl methacrylate polymer |
| Definition | Basic methacrylate copolymer is manufactured by thermic controlled polymerisation of the monomers methyl methacrylate, butyl methacrylate and dimethylaminoethyl methacrylate, dissolved in propan-2-ol) by using a free radical donor initiator system. An alkyl mercaptane is used as chain modifying agent. The solid polymer is milled (first milling step) and extruded and granulated under vacuum to remove residual volatile components. The granules resulting are commercialised as such or undergo a second milling step (micronisation). |
| Chemical name | Poly(butyl methacrylate-co-(2-dimethylaminoethyl)methacrylate-co-methyl methacrylate) 1:2:1 |
| Chemical formula | Poly[(CH2:C(CH3)CO2(CH2)2N(CH3)2)-co-(CH2:C(CH3)CO2CH3)-co-(CH2:C(CH3)CO2(CH2)3CH3)] |
| Weight average molecular weight estimated by gel permeation chromatography | Approximately 47 000 g/mol |
| Particle size of powder (when used forms a film) | < 50 μm more than 50 % < 0,1 μm 5,1-5,5 % |
| Assay (according to Ph. Eur. 2.2.20 ‘potentiometric titration’) | 20,8-25,5 % dimethylaminoethyl (DMAE) groups on dry substance |
| Description | Granules are colourless to yellow tinged, the powder is white |
| Identification | |
|---|---|
| Infrared absorption spectroscopy | To be identified |
| Viscosity of a 12,5 % solution in 60:40 (w/w/) propan-2-ol to acetone | 3-6 mPa.s |
| Refractive index | [n]D 20 1,380-1,385 |
| Solubility | 1 g dissolves in 7 g Methanol, Ethanol, propan-2-ol, dichloromethane, aqueous Hydrochloric acid 1N. Not soluble in petroleum ether. |
| Purity | |
| Loss of drying | Not more than 2,0 % (105 °C, 3H) |
| Alkali value | 162-198 mg KOH/g of dried substance |
| Sulphated ash | Not more than 0,1 % |
| Residual monomers | Butylmethacrylate < 1 000 mg/kg Methyl methacrylate < 1 000 mg/kg Dimethylaminoethyl methacrylate < 1 000 mg/kg |
| Solvent residues | propan-2-ol < 0,5 % Butanol < 0,5 % Methanol < 0,1 % |
| Arsenic | Not more than 2 mg/kg |
| Lead | Not more than 2 mg/kg |
| Mercury | Not more than 2 mg/kg |
| Copper | Not more than 10 mg/kg |