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Commission Regulation (EU) 2019/831

of 22 May 2019

amending Annexes II, III and V to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products

(Text with EEA relevance)

THE EUROPEAN COMMISSION,

Having regard to the Treaty on the Functioning of the European Union,

Having regard to Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products(1), and in particular Article 15(1), the fourth subparagraph of Article 15(2) and Article 31(1) thereof,

Whereas:

(1) Regulation (EC) No 1272/2008 of the European Parliament and of the Council(2) provides for a harmonised classification of substances as carcinogenic, mutagenic or toxic for reproduction (CMR) based on a scientific assessment by the Risk Assessment Committee of the European Chemicals Agency. The substances are classified as CMR substances of category 1A, CMR substances of category 1B or CMR substances of category 2 depending on the level of evidence of their CMR properties.

(2) Article 15 of Regulation (EC) No 1223/2009 provides that substances which have been classified as CMR substances of category 1A, category 1B or category 2 under Part 3 of Annex VI to Regulation (EC) No 1272/2008 (CMR substances) are prohibited from use in cosmetic products. A CMR substance may however be used in cosmetic products where the conditions laid down in the second sentence of Article 15(1) or in the second subparagraph of Article 15(2) of Regulation (EC) No 1223/2009 are fulfilled. This Regulation implements Regulation (EC) No 1223/2009. Only the Court of Justice of the European Union is entitled to interpret Union law, including Article 15 of Regulation (EC) No 1223/2009.

(3) In order to uniformly implement the prohibition of CMR substances within the internal market, to ensure legal certainty, in particular for economic operators and national competent authorities and to ensure a high level of protection of human health, all CMR substances should be included in the list of prohibited substances in Annex II to Regulation (EC) No 1223/2009 and, where relevant, deleted from the lists of restricted or authorised substances in Annexes III and V to that Regulation. Where the conditions laid down in the second sentence of Article 15(1) or the second subparagraph of Article 15(2) of Regulation (EC) No 1223/2009 are fulfilled, the lists of restricted or authorised substances in Annexes III and V to that Regulation should be amended accordingly.

(4) This Regulation covers the substances which have been classified as CMR substances pursuant to Regulation (EC) No 1272/2008 as at 1 December 2018, when Commission Regulation (EU) 2017/776(3) became applicable.

(5) Concerning certain CMR substances for which a request for use in cosmetic products by way of exception has been submitted, it has not been established that all the conditions provided for in the second sentence of Article 15(1) or the second subparagraph of Article 15(2) of Regulation (EC) No 1223/2009 are fulfilled. This concerns Quaternium-15, Chloroacetamide, Dichloromethane, Formaldehyde, Perboric acid and Sodium perborate compounds

(6) The substance Methenamine 3-chloroallylochloride, with the International Nomenclature of Cosmetic Ingredients (INCI) name Quaternium-15, is currently listed in entry 31 of Annex V to Regulation (EC) No 1223/2009 as allowed in a concentration of up to 0,2 % in ready for use preparation. Quaternium-15 is a mixture of cis and trans isomers of which the cis-isomer has been classified as a CMR substance of category 2 by Commission Regulation (EC) No 790/2009(4). The classification became applicable on 1 December 2010. In accordance with the second sentence of Article 15(1) of Regulation (EC) No 1223/2009, a substance classified in category 2 may be used in cosmetic products where the substance has been evaluated by the Scientific Committee on Consumer Safety (SCCS) and found safe for use in cosmetic products. On 13 and 14 December 2011, the SCCS issued a scientific opinion on Quaternium-15 (cis-isomer)(5), which concluded that on the basis of the available data the safety of Quaternium-15 for use in cosmetic products cannot be established. In light of the classification of the cis-isomer present in Quaternium-15 as a CMR substance of category 2 and the opinion of the SCCS, Quaternium-15 should be deleted from the list of preservatives allowed in cosmetic products in Annex V to Regulation (EC) No 1223/2009 and added to the list of substances prohibited in cosmetic products in Annex II to that Regulation.

(7) The substance 2-Chloroacetamide, with the INCI name Chloroacetamide, is currently listed in entry 41 of Annex V to Regulation (EC) No 1223/2009 as allowed in a concentration of up to 0,3 % in ready for use preparation. Chloroacetamide has been classified as a CMR substance of category 2 under Regulation (EC) No 1272/2008. The classification became applicable before 1 December 2010, at which date Titles II, III and IV of Regulation (EC) No 1272/2008 became applicable in respect of substances. In accordance with the second sentence of Article 15(1) of Regulation (EC) No 1223/2009, a substance classified in category 2 may be used in cosmetic products where the substance has been evaluated by the SCCS and found safe for use in such products. On 22 March 2011, the SCCS issued a scientific opinion on Chloroacetamide(6) which concluded that, on the basis of the available data, the substance is not safe for consumers when used in a concentration of up to 0,3 % w/w in cosmetic products. In light of the classification as a CMR substance of category 2 and the opinion of the SCCS, Chloroacetamide should be deleted from the list of preservatives allowed in cosmetic products in Annex V to Regulation (EC) No 1223/2009 and added to the list of substances prohibited in cosmetic products in Annex II to that Regulation.

(8) The substance Dichloromethane is currently listed in entry 7 of Annex III to Regulation (EC) No 1223/2009 as allowed in cosmetic products in a concentration of up to 35 % in ready for use preparation. Dichloromethane has been classified as a CMR substance of category 2 under Regulation (EC) No 1272/2008. The classification became applicable before 1 December 2010. In accordance with the second sentence of Article 15(1) of Regulation (EC) No 1223/2009, a substance classified in category 2 may be used in cosmetic products where the substance has been evaluated by the SCCS and found safe for use in such products. On 11 December 2012, the SCCS issued a scientific opinion on Dichloromethane(7). On 25 March 2015, the SCCS issued a new opinion(8) which was revised on 28 October 2015. In that revised opinion the SCCS concluded that the use of Dichloromethane in a concentration of up to 35 % in hair sprays and its use in spray formulations in general is not considered safe for the consumer. In light of the classification as a CMR substance of category 2 and the opinion of the SCCS, and since no other uses of Dichloromethane in cosmetic products are known and have been covered by the SCCS opinion, the substance should be deleted from the list of restricted substances in Annex III to Regulation (EC) No 1223/2009 and added to the list of substances prohibited in cosmetic products in Annex II to that Regulation.

(9) The substance Formaldehyde is currently listed in entry 13 of Annex III to Regulation (EC) No 1223/2009 as allowed in nail hardening products in a concentration of up to 5 % in ready for use preparation. It is also currently listed in entry 5 of Annex V to Regulation (EC) No 1223/2009 as allowed in oral products in a concentration of up to 0,1 % and in other products in a concentration of up to 0,2 %. Formaldehyde has been classified as a CMR substance of category 1B by Commission Regulation (EU) No 605/2014(9). The classification became applicable on 1 January 2016. In accordance with the second subparagraph of Article 15(2) of Regulation (EC) No 1223/2009, substances classified as CMR substances of category 1A or 1B may be used in cosmetic products by way of exception where, subsequent to their classification as CMR substances, certain conditions are fulfilled, including the conditions that no suitable alternative substances are available, that an application is made for a particular use of the product category with a known exposure and that the substance has been evaluated and found safe by the SCCS. On 7 November 2014, the SCCS concluded in its opinion(10) that ‘nail hardeners with a maximum concentration of about 2,2 % free formaldehyde can be used safely to harden or strengthen nails’. However, since it has not been established that there are no suitable alternative substances available for the purpose of hardening nails, Formaldehyde should be deleted from the list of restricted substances in Annex III to Regulation (EC) No 1223/2009. Since no application was made for other uses of Formaldehyde, the substance should be deleted from the list of preservatives allowed in cosmetic products in Annex V to that Regulation. Formaldehyde should also be added to the list of substances prohibited in cosmetic products in Annex II to Regulation (EC) No 1223/2009.

(10) Perboric acid and Sodium perborate compounds are covered by the hydrogen peroxide releasing substances currently listed in entry 12 of Annex III to Regulation (EC) No 1223/2009. They have been classified as CMR substances of category 1B by Regulation (EC) No 790/2009. The classification became applicable by 1 December 2010. A request for the application of the second subparagraph of Article 15(2) of Regulation (EC) No 1223/2009 was submitted for the use of those substances in oxidative hair dye formulations. On 22 June 2010, the SCCS concluded in its opinion(11) that the ‘general restrictions applicable to hydrogen peroxide releasing substances should apply to sodium perborate and perboric acid and that the use of sodium perborates as an ingredient in oxidative hair dye formulations with a maximum on-head concentration of 3 % will not pose a risk to the health of the consumer’. However, since it has not been established that there are no suitable alternative substances available for the purpose of oxidation of hair, Perboric acid and Sodium perborate compounds should be deleted from the list of restricted substances in Annex III to Regulation (EC) No 1223/2009 and added to the list of substances prohibited in cosmetic products in Annex II to that Regulation.

(11) Concerning certain substances which were classified as CMR substances under Regulation (EC) No 1272/2008 and for which a request for the application of the second sentence of Article 15(1) of Regulation (EC) No 1223/2009 has been submitted, it has been established that the condition provided for in that provision is fulfilled. This concerns Trimethylbenzoyl diphenylphosphine oxide, Furfural and Polyaminopropyl biguanide.

(12) The substance Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide, with the INCI name Trimethylbenzoyl diphenylphosphine oxide (TPO), is currently not included in the Annexes to Regulation (EC) No 1223/2009. TPO has been classified as a CMR substance of category 2 by Commission Regulation (EU) No 618/2012(12). The classification became applicable on 1 December 2013. On 27 March 2014, the SCCS issued a scientific opinion(13) which concluded that TPO is safe when used as a nail modelling product in a concentration of up to 5,0 % but that it is however a moderate skin sensitizer. Considering the skin sensitising properties of TPO and the high risk of exposure through skin contact in case of self-application of nail products, the use of TPO should be restricted to professionals only. In light of those elements, TPO should be added to the list of restricted substances in Annex III to Regulation (EC) No 1223/2009 for professional use in artificial nail systems with a maximum concentration of 5 %.

(13) The substance 2-Furaldehyde, with the INCI name Furfural, is used as a fragrance or flavour ingredient in cosmetic products and is currently not included in the Annexes to Regulation (EC) No 1223/2009. It has been classified as a CMR substance of category 2 under Regulation (EC) No 1272/2008. The classification became applicable before 1 December 2010. On 27 March 2012, the SCCS concluded in its opinion(14) that the use of Furfural in a concentration of up to 10 ppm (0,001 %) in ready for use preparation, including oral products, does not pose any risk to the health of the consumer. In light of the classification of Furfural as a CMR substance of category 2 and the opinion of the SCCS, Furfural should be added to the list of restricted substances in Annex III to Regulation (EC) No 1223/2009 with a maximum concentration of 0,001 %.

(14) The substance Polyhexamethylene biguanide hydrochloride (PHMB), with the INCI name Polyaminopropyl Biguanide, is currently listed as a preservative in entry 28 of Annex V to Regulation (EC) No 1223/2009 with a maximum concentration of 0,3 %. It has been classified as a CMR substance of category 2 by Commission Regulation (EU) No 944/2013(15). The classification became applicable on 1 January 2015. On 18 June 2014, the SCCS adopted an opinion(16) which concluded that on the basis of the data available, PHMB is not safe for consumers when used as a preservative in all cosmetic products at a maximum concentration of 0,3 %. However, the SCCS opinion also concluded that the safe use could be based on a lower use concentration and/or restrictions with regard to cosmetic products' categories and that dermal absorption studies on additional representative cosmetic formulations are needed. On 7 April 2017, the SCCS adopted a new opinion(17) which concluded that, based on the data provided, the use of PHMB as a preservative in all cosmetic products up to 0,1 % is safe but that its use in sprayable formulations is not advised. In light of the classification of PHMB as a CMR substance of category 2 and of the new SCCS opinion, PHMB should be authorised as a preservative in all cosmetic products, except in applications that may lead to exposure of the end-user's lungs by inhalation, with a maximum concentration of 0,1 %. The conditions set out in Annex V to Regulation (EC) No 1223/2009 should be adapted accordingly.

(15) Concerning a large group of substances which were classified as CMR substances under Regulation (EC) No 1272/2008, no request for use in cosmetic products by way of exception has been submitted. Those substances should be included in the list of prohibited substances in Annex II to Regulation (EC) No 1223/2009 and, where relevant, deleted from the lists of restricted or authorised substances in Annexes III and V to that Regulation. This concerns, inter alia, some boron compounds currently listed in entries 1a and 1b of Annex III to Regulation (EC) No 1223/2009.

(16) Some boron compounds currently listed in entries 1a and 1b of Annex III to Regulation (EC) No 1223/2009 and Dibutyltin hydrogen borate have been classified as CMR substances of category 1B by Regulation (EC) No 790/2009. The classification became applicable by 1 December 2010. In accordance with the second subparagraph of Article 15(2) of Regulation (EC) No 1223/2009, substances classified as CMR substances of category 1A or 1B may be used in cosmetic products by way of exception where, subsequent to their classification as CMR substances, certain conditions are fulfilled. On 22 June 2010, the SCCS issued an opinion(18) which concluded that some of the boron compounds currently listed in entries 1a and 1b of Annex III to that Regulation are safe for use in cosmetics under certain conditions. However, since no application for a particular use was made and since it has not been established that there are no suitable alternative substances available for the purpose of the relevant uses listed in Annex III to Regulation (EC) No 1223/2009, those boron compounds should be deleted from the list of restricted substances in Annex III to that Regulation and added to the list of substances prohibited in cosmetic products in Annex II to Regulation (EC) No 1223/2009. As regards Dibutyltin hydrogen borate, no application for a particular use was made and it has not been found safe by the SCCS. That substance should therefore be added to the list of substances prohibited in cosmetic products in Annex II to Regulation (EC) No 1223/2009.

(17) Article 31(1) of Regulation (EC) No 1223/2009 provides that where there is a potential risk to human health, arising from the use of substances in cosmetic products, which needs to be addressed on a Community-wide basis, the Commission may, after consulting the SCCS, amend Annexes II to VI to that Regulation accordingly. The Commission has consulted the SCCS on the safety of certain substances which are similar from a chemical perspective to substances classified as CMR substances of categories 1A, 1B or 2. This concerns certain boron compounds as well as Paraformaldehyde and Methylene Glycol.

(18) Certain boron compounds currently listed in entries 1a and 1b of Annex III to Regulation (EC) No 1223/2009, other than those referred to in Recital 16, have not been classified as CMR substances. On 12 December 2013, the SCCS issued an opinion on borates, tetraborates and octaborates(19), where it concluded that those substances, as well as other boric acid salts or esters, such as MEA-borate, MIPA-borate, potassium borate, trioctyldodecyl borate and zinc borate, form boric acid in aqueous solutions and that therefore the general restrictions applicable to boric acid should apply to the whole group of borates, tetraborates and octaborates. Boric acid has been classified as a CMR substance of category 1B by Regulation (EC) No 790/2009. The classification became applicable by 1 December 2010. In light of the opinion of the SCCS, the whole group of borates, tetraborates and octaborates, except the substances in that group that have been classified as CMR substances, as well as other boric acid salts or esters, should be deleted from the list of restricted substances in Annex III to Regulation (EC) No 1223/2009 and added to the list of substances prohibited in cosmetic products in Annex II to that Regulation.

(19) The substance Paraformaldehyde is currently listed in entry 5 of Annex V to Regulation (EC) No 1223/2009 but, contrary to Formaldehyde, it has not been classified as a CMR substance. The substance Methylene Glycol is currently not included in the Annexes to Regulation (EC) No 1223/2009. On 26–27 June 2012, the SCCS adopted an opinion on Methylene Glycol(20) which established that Methylene Glycol is rapidly reversible under a variety of conditions to form Formaldehyde in aqueous solutions and that Paraformaldehyde can depolymerise to form Formaldehyde by heating or drying. In light of the opinion of the SCCS, there is a potential risk to human health arising from the use of those substances in cosmetic products. Paraformaldehyde should therefore be deleted from the list of preservatives allowed in cosmetic products in Annex V to Regulation (EC) No 1223/2009 and Paraformaldehyde and Methylene Glycol should be added to the list of substances prohibited in cosmetic products in Annex II to that Regulation.

(20) Regulation (EC) No 1223/2009 should therefore be amended accordingly.

(21) The measures provided for in this Regulation are in accordance with the opinion of the Standing Committee on Cosmetic Products,

HAS ADOPTED THIS REGULATION:

Article 1U.K.

Annexes II, III and V to Regulation (EC) No 1223/2009 are amended in accordance with the Annex to this Regulation.

Article 2U.K.

This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union.

This Regulation shall be binding in its entirety and directly applicable in all Member States.

Done at Brussels, 22 May 2019.

For the Commission

The President

Jean-Claude Juncker

ANNEXU.K.

(1)Annex II is amended as follows:U.K.

(a)

the following entries are added:

Reference numberSubstance identification
Chemical name/INNCAS numberEC number
abcd
‘1385Cis-1-(3-chloroallyl)-3,5,7- triaza-1-azoniaadamantane chloride (cis-CTAC)51229-78-8426-020-3
1386Cis-1-(3-chlorallyl)-3,5,7-triaza-1-azoniaadamantane chloride (cis-CTAC), quaternium-1551229-78-8426-020-3
13872-Chloracetamide79-07-2201-174-2
1388Octamethylcyclotetrasiloxane556-67-2209-136-7
1389Dichloromethane; methylene chloride75-09-2200-838-9
13902,2′-((3,3′,5,5′-Tetramethyl-(1,1′-biphenyl)-4,4′-diyl)-bis(oxymethylene))-bis-oxirane85954-11-6413-900-7
1391Acetaldehyde; ethanal75-07-0200-836-8
13921-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid93107-30-3413-760-7
1393 N-Methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone872-50-4212-828-1
1394Diboron trioxide; boric oxide1303-86-2215-125-8
1395

Boric acid [1]

Boric acid [2]

10043-35-3 [1]

11113-50-1 [2]

233-139-2 [1]

234-343-4 [2]

1396Borates, tetraborates, octaborates and boric acid salts and esters, including:
Disodium octaborate tetrahydrate [1]12280-03-4 [1]234-541-0 [1]
2-Aminoethanol, monoester with boric acid [2]10377-81-8 [2]233-829-3 [2]
2-Hydroxypropyl ammonium dihydrogen orthoborate [3]68003-13-4 [3]268-109-8 [3]
Potassium borate, boric acid potassium salt [4]12712-38-8 [4]603-184-6 [4]
Trioctyldodecyl borate [5][5]— [5]
Zinc borate [6]1332-07-6 [6]215-566-6 [6]
Sodium borate, disodium tetraborate anhydrous; boric acid, sodium salt [7]1330-43-4 [7]215-540-4 [7]
Tetraboron disodium heptaoxide, hydrate [8]12267-73-1 [8]235-541-3 [8]
Orthoboric acid, sodium salt [9]13840-56-7 [9]237-560-2 [9]
Disodium tetraborate decahydrate; borax decahydrate [10]1303-96-4 [10]215-540-4 [10]
Disodium tetraborate pentahydrate; borax pentahydrate [11]12179-04-3 [11]215-540-4 [11]
1397

Sodium perborate [1]

Sodium peroxometaborate; sodium peroxoborate [2]

15120-21-5 [1]239-172-9 [1]

7632-04-4 [2]

10332-33-9 [2]

10486-00-7[2]

231-556-4 [2]
1398Perboric acid (H3BO2(O2)), monosodium salt trihydrate [1]13517-20-9 [1]239-172-9 [1]
Perboric acid, sodium salt, tetrahydrate [2]37244-98-7 [2]234-390-0 [2]
Perboric acid (HBO(O2)), sodium salt, tetrahydrate sodium peroxoborate hexahydrate [3]10486-00-7 [3]231-556-4 [3]
1399Perboric acid, sodium salt [1]11138-47-9 [1]234-390-0 [1]
Perboric acid, sodium salt, monohydrate [2]12040-72-1 [2]234-390-0 [2]
Perboric acid (HBO(O2)), sodium salt, monohydrate [3]10332-33-9 [3]231-556-4 [3]
1400Dibutyltin hydrogen borate75113-37-0401-040-5
1401Nickel bis(tetrafluoroborate)14708-14-6238-753-4
1402Mancozeb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt8018-01-7616-995-5
1403Maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric)12427-38-2235-654-8
1404Benfuracarb (ISO); ethyl N-[2,3-dihydro-2,2-dimethylbenzofuran-7-yloxycarbonyl(methyl)aminothio]-N-isopropyl- β-alaninate82560-54-1617-356-3
1405 O-Isobutyl-N-ethoxy carbonylthiocarbamate103122-66-3434-350-4
1406Chlorpropham (ISO); isopropyl 3-chlorocarbanilate101-21-3202-925-7
1407 O-Hexyl-N-ethoxycarbonylthiocarbamate109202-58-6432-750-3
1408Hydroxylammonium nitrate13465-08-2236-691-2
1409(4-Ethoxyphenyl)(3-(4-fluoro-3-phenoxyphenyl)propyl)dimethylsilane105024-66-6405-020-7
1410Phoxim (ISO); α-(diethoxy-phosphinothioylimino) phenylacetonitrile14816-18-3238-887-3
1411Glufosinate ammonium (ISO); ammonium 2-amino-4-(hydroxymethylphosphinyl)butyrate77182-82-2278-636-5
1412Reaction mass of: dimethyl (2-(hydroxymethylcarbamoyl)ethyl)phosphonate; diethyl (2-(hydroxymethylcarbamoyl)ethyl)phosphonate; methyl ethyl (2-(hydroxymethylcarbamoyl)ethyl)phosphonate—435-960-3
1413(4-Phenylbutyl)phosphinic acid86552-32-1420-450-5
1414Reaction mass of: 4,7-bis(mercaptomethyl)-3,6,9-trithia-1,11-undecanedithiol; 4,8-bis(mercaptomethyl)-3,6,9-trithia-1,11-undecanedithiol; 5,7-bis(mercaptomethyl)-3,6,9-trithia-1,11-undecanedithiol170016-25-8427-050-1
1415Potassium titanium oxide (K2Ti6O13)12056-51-8432-240-0
1416Cobalt di(acetate)71-48-7200-755-8
1417Cobalt dinitrate10141-05-6233-402-1
1418Cobalt carbonate513-79-1208-169-4
1419Nickel dichloride7718-54-9231-743-0
1420Nickel dinitrate [1]13138-45-9 [1]236-068-5 [1]
Nitric acid, nickel salt [2]14216-75-2 [2]238-076-4 [2]
1421Nickel matte69012-50-6273-749-6
1422Slimes and sludges, copper electrolytic refining, decopperised, nickel sulfate92129-57-2295-859-3
1423Slimes and sludges, copper electrolyte refining, decopperised94551-87-8305-433-1
1424Nickel diperchlorate; perchloric acid, nickel(II) salt13637-71-3237-124-1
1425Nickel dipotassium bis(sulfate) [1]13842-46-1 [1]237-563-9 [1]
Diammonium nickel bis(sulfate) [2]15699-18-0 [2]239-793-2 [2]
1426Nickel bis(sulfamidate); nickel sulfamate13770-89-3237-396-1
1427Nickel bis(tetrafluoroborate)14708-14-6238-753-4
1428Nickel diformate [1]3349-06-2 [1]222-101-0 [1]
Formic acid, nickel salt [2]15843-02-4 [2]239-946-6 [2]
Formic acid, copper nickel salt [3]68134-59-8 [3]268-755-0 [3]
1429Nickel di(acetate) [1]373-02-4 [1]206-761-7 [1]
Nickel acetate [2]14998-37-9 [2]239-086-1 [2]
1430Nickel dibenzoate553-71-9209-046-8
1431Nickel bis(4-cyclohexylbutyrate)3906-55-6223-463-2
1432Nickel(II) stearate; nickel(II) octadecanoate2223-95-2218-744-1
1433Nickel dilactate16039-61-5—
1434Nickel(II) octanoate4995-91-9225-656-7
1435Nickel difluoride [1]10028-18-9 [1]233-071-3 [1]
Nickel dibromide [2]13462-88-9 [2]236-665-0 [2]
Nickel diiodide [3]13462-90-3 [3]236-666-6 [3]
Nickel potassium fluoride [4]11132-10-8 [4]— [4]
1436Nickel hexafluorosilicate26043-11-8247-430-7
1437Nickel selenate15060-62-5239-125-2
1438Nickel hydrogen phosphate [1]14332-34-4 [1]238-278-2 [1]
Nickel bis(dihydrogen phosphate) [2]18718-11-1 [2]242-522-3 [2]
Trinickel bis(orthophosphate) [3]10381-36-9 [3]233-844-5 [3]
Dinickel diphosphate [4]14448-18-1 [4]238-426-6 [4]
Nickel bis(phosphinate) [5]14507-36-9 [5]238-511-8 [5]
Nickel phosphinate [6]36026-88-7 [6]252-840-4 [6]
Phosphoric acid, calcium nickel salt [7]17169-61-8 [7]— [7]
Diphosphoric acid, nickel(II) salt [8]19372-20-4 [8]— [8]
1439Diammonium nickel hexacyanoferrate74195-78-1—
1440Nickel dicyanide557-19-7209-160-8
1441Nickel chromate14721-18-7238-766-5
1442Nickel(II) silicate [1]21784-78-1 [1]244-578-4 [1]
Dinickel orthosilicate [2]13775-54-7 [2]237-411-1 [2]
Nickel silicate (3:4) [3]31748-25-1 [3]250-788-7 [3]
Silicic acid, nickel salt [4]37321-15-6 [4]253-461-7 [4]
Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5]12519-85-6 [5]235-688-3 [5]
1443Dinickel hexacyanoferrate14874-78-3238-946-3
1444Trinickel bis(arsenate); nickel(II) arsenate13477-70-8236-771-7
1445Nickel oxalate [1]547-67-1 [1]208-933-7 [1]
Oxalic acid, nickel salt [2]20543-06-0 [2]243-867-2 [2]
1446Nickel telluride12142-88-0235-260-6
1447Trinickel tetrasulfide12137-12-1—
1448Trinickel bis(arsenite)74646-29-0—
1449Cobalt nickel gray periclase; C.I. Pigment Black 25; C.I. 77332 [1]68186-89-0 [1]269-051-6 [1]
Cobalt nickel dioxide [2]58591-45-0 [2]261-346-8 [2]
Cobalt nickel oxide [3]12737-30-3 [3]620-395-9 [3]
1450Nickel tin trioxide; nickel stannate12035-38-0234-824-9
1451Nickel triuranium decaoxide15780-33-3239-876-6
1452Nickel dithiocyanate13689-92-4237-205-1
1453Nickel dichromate15586-38-6239-646-5
1454Nickel(II) selenite10101-96-9233-263-7
1455Nickel selenide1314-05-2215-216-2
1456Silicic acid, lead nickel salt68130-19-8—
1457Nickel diarsenide [1]12068-61-0 [1]235-103-1 [1]
Nickel arsenide [2]27016-75-7 [2]248-169-1 [2]
1458Nickel barium titanium primrose priderite; C.I. Pigment Yellow 157; C.I. 7790068610-24-2271-853-6
1459Nickel dichlorate [1]67952-43-6 [1]267-897-0 [1]
Nickel dibromate [2]14550-87-9 [2]238-596-1 [2]
Ethyl hydrogen sulfate, nickel(II) salt [3]71720-48-4 [3]275-897-7 [3]
1460Nickel(II) trifluoroacetate [1]16083-14-0 [1]240-235-8 [1]
Nickel(II) propionate [2]3349-08-4 [2]222-102-6 [2]
Nickel bis(benzenesulfonate) [3]39819-65-3 [3]254-642-3 [3]
Nickel(II) hydrogen citrate [4]18721-51-2 [4]242-533-3 [4]
Citric acid, ammonium nickel salt [5]18283-82-4 [5]242-161-1 [5]
Citric acid, nickel salt [6]22605-92-1 [6]245-119-0 [6]
Nickel bis(2-ethylhexanoate) [7]4454-16-4 [7]224-699-9 [7]
2-Ethylhexanoic acid, nickel salt [8]7580-31-6 [8]231-480-1 [8]
Dimethylhexanoic acid, nickel salt [9]93983-68-7 [9]301-323-2 [9]
Nickel(II) isooctanoate [10]29317-63-3 [10]249-555-2 [10]
Nickel isooctanoate [11]27637-46-3 [11]248-585-3 [11]
Nickel bis(isononanoate) [12]84852-37-9 [12]284-349-6 [12]
Nickel(II) neononanoate [13]93920-10-6 [13]300-094-6 [13]
Nickel(II) isodecanoate [14]85508-43-6 [14]287-468-1 [14]
Nickel(II) neodecanoate [15]85508-44-7 [15]287-469-7 [15]
Neodecanoic acid, nickel salt [16]51818-56-5 [16]257-447-1 [16]
Nickel(II) neoundecanoate [17]93920-09-3 [17]300-093-0 [17]
Bis(d.-gluconato-O 1,O 2)nickel [18]71957-07-8 [18]276-205-6 [18]
Nickel 3,5-bis(tert-butyl)-4-hydroxybenzoate (1:2) [19]52625-25-9 [19]258-051-1 [19]
Nickel(II) palmitate [20]13654-40-5 [20]237-138-8 [20]
(2-Ethylhexanoato-O)(isononanoato-O)nickel [21]85508-45-8 [21]287-470-2 [21]
(Isononanoato-O)(isooctanoato-O)nickel [22]85508-46-9 [22]287-471-8 [22]
(Isooctanoato-O)(neodecanoato-O)nickel [23]84852-35-7 [23]284-347-5 [23]
(2-Ethylhexanoato-O)(isodecanoato-O)nickel [24]84852-39-1 [24]284-351-7 [24]
(2-Ethylhexanoato-O)(neodecanoato-O)nickel [25]85135-77-9 [25]285-698-7 [25]
(Isodecanoato-O)(isooctanoato-O)nickel [26]85166-19-4 [26]285-909-2 [26]
(Isodecanoato-O)(isononanoato-O)nickel [27]84852-36-8 [27]284-348-0 [27]
(Isononanoato-O)(neodecanoato-O)nickel [28]85551-28-6 [28]287-592-6 [28]
Fatty acids, C6-19-branched, nickel salts [29]91697-41-5 [29]294-302-1 [29]
Fatty acids, C8-18 and C18-unsaturated, nickel salts [30]84776-45-4 [30]283-972-0 [30]
2,7-Naphthalenedisulfonic acid, nickel(II) salt [31]72319-19-8 [31][31]
1461Nickel(II) sulfite [1]7757-95-1 [1]231-827-7 [1]
Nickel tellurium trioxide [2]15851-52-2 [2]239-967-0 [2]
Nickel tellurium tetraoxide [3]15852-21-8 [3]239-974-9 [3]
Molybdenum nickel hydroxide oxide phosphate [4]68130-36-9 [4]268-585-7 [4]
1462Nickel boride (NiB) [1]12007-00-0 [1]234-493-0 [1]
Dinickel boride [2]12007-01-1 [2]234-494-6 [2]
Trinickel boride [3]12007-02-2 [3]234-495-1 [3]
Nickel boride [4]12619-90-8 [4]235-723-2 [4]
Dinickel silicide [5]12059-14-2 [5]235-033-1 [5]
Nickel disilicide [6]12201-89-7 [6]235-379-3 [6]
Dinickel phosphide [7]12035-64-2 [7]234-828-0 [7]
Nickel boron phosphide [8]65229-23-4 [8]— [8]
1463Dialuminium nickel tetraoxide [1]12004-35-2 [1]234-454-8 [1]
Nickel titanium trioxide [2]12035-39-1 [2]234-825-4 [2]
Nickel titanium oxide [3]12653-76-8 [3]235-752-0 [3]
Nickel divanadium hexaoxide [4]52502-12-2 [4]257-970-5 [4]
Cobalt dimolybdenum nickel octaoxide [5]68016-03-5 [5]268-169-5 [5]
Nickel zirkonium trioxide [6]70692-93-2 [6]274-755-1 [6]
Molybdenum nickel tetraoxide [7]14177-55-0 [7]238-034-5 [7]
Nickel tungsten tetraoxide [8]14177-51-6 [8]238-032-4 [8]
Olivine, nickel green [9]68515-84-4 [9]271-112-7 [9]
Lithium nickel dioxide [10]12031-65-1 [10]620-400-4 [10]
Molybdenum nickel oxide [11]12673-58-4 [11]— [11]
1464Cobalt lithium nickel oxide—442-750-5
1465Molybdenum trioxide1313-27-5215-204-7
1466Dibutyltin dichloride; (DBTC)683-18-1211-670-0
14674,4′-Bis(N-carbamoyl-4-methylbenzenesulfonamide)diphenylmethane151882-81-4418-770-5
1468Furfuryl alcohol98-00-0202-626-1
14691,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide106-87-6203-437-7
14706-Glycidyloxynapht-1-yl oxymethyloxirane27610-48-6429-960-2
14712-(2-Aminoethylamino)ethanol; (AEEA)111-41-1203-867-5
14721,2-Diethoxyethane629-14-1211-076-1
14732,3-Epoxypropyltrimethylammonium chloride; glycidyl trimethylammonium chloride3033-77-0221-221-0
14741-(2-Amino-5-chlorophenyl)-2,2,2-trifluoro-1,1-ethanediol, hydrochloride214353-17-0433-580-2
1475(E)-3-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol82413-20-5428-010-4
14764,4′-(1,3-Phenylene-bis(1-methylethylidene))bis-phenol13595-25-0428-970-4
14772-Chloro-6-fluoro-phenol2040-90-6433-890-8
14782-Methyl-5-tert-butylthiophenol—444-970-7
14792-Butyryl-3-hydroxy-5-thiocyclohexan-3-yl-cyclohex-2-en-1-one94723-86-1425-150-8
1480Profoxydim (ISO); 2-{(EZ)-1-[(2RS)-2-(4-chlorophenoxy)propoxyimino]butyl}-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one139001-49-3604-105-8
1481Tepraloxydim (ISO); (RS)-(EZ)-2-{1-[(2E)-3-chloroallyloxyimino]propyl}-3-hydroxy-5-perhydropyran-4-ylcyclohex-2-en-1-one149979-41-9604-715-4
1482Cyclic 3-(1,2-ethanediylacetale)-estra-5(10),9(11)-diene-3,17-dione5571-36-8427-230-8
1483Androsta-1,4,9(11)-triene-3,17-dione15375-21-0433-560-3
1484Reaction mass of: Ca salicylates (branched C10-14 and C18-30 alkylated); Ca phenates (branched C10-14 and C18-30 alkylated); Ca sulfurised phenates (branched C10-14 and C18-30 alkylated)—415-930-6
14851,2-Benzenedicarboxylic acid; di-C6-8-branched alkylesters, C7-rich71888-89-6276-158-1
1486Reaction mass of: diester of 4,4′-methylenebis[2-(2-hydroxy-5-methylbenzyl)-3,6-dimethylphenol] and 6-diazo-5,6-dihydro-5-oxonaphthalene-1-sulfonic acid (1:2); triester of 4,4′-methylenebis[2-(2-hydroxy-5-methylbenzyl)-3,6-dimethylphenol] and 6-diazo-5,6-dihydro-5-oxonaphthalene-1-sulfonic acid (1:3)—427-140-9
1487Diammonium 1-hydroxy-2-(4-(4-carboxyphenylazo)-2,5-dimethoxyphenylazo)-7-amino-3-naphthalenesulfonate150202-11-2422-670-7
14883-Oxoandrost-4-ene-17-β-carboxylic acid302-97-6414-990-0
1489(Z)-2-Methoxymino-2-[2-(tritylamino)thiazol-4-yl]acetic acid64485-90-1431-520-1
1490Trisodium nitrilotriacetate5064-31-3225-768-6
14912-Ethylhexyl-2-ethylhexanoate7425-14-1231-057-1
1492Diisobutyl phthalate84-69-5201-553-2
1493Perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]1763-23-1 [1]217-179-8 [1]
Potassium perfluorooctanesulfonate; potassium heptadecafluorooctane-1-sulfonate [2]2795-39-3 [2]220-527-1 [2]
Diethanolamine perfluorooctane sulfonate [3]70225-14-8 [3]274-460-8 [3]
Ammonium perfluorooctane sulfonate; ammonium heptadecafluorooctanesulfonate [4]29081-56-9 [4]249-415-0 [4]
Lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate [5]29457-72-5 [5]249-644-6 [5]
1494Ethyl 1-(2,4-dichlorophenyl)5-(trichloromethyl)-1H-1,2,4-triazole-3-carboxylate103112-35-2401-290-5
14951-Bromo-2-methylpropyl propionate158894-67-8422-900-6
1496Chloro-1-ethylcyclohexyl carbonate99464-83-2444-950-8
14976,6′-Bis(diazo-5,5′,6,6′-tetrahydro-5,5′-dioxo)[methylene-bis(5-(6-diazo-5,6-dihydro-5-oxo-1-naphthylsulphonyloxy)-6-methyl-2-phenylene]di(naphthalene-1-sulfonate)—441-550-5
1498Trifluralin (ISO); α,α,α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine; 2,6-dinitro-N,N-dipropyl-4-trifluoromethylaniline; N,N-dipropyl-2,6-dinitro-4-trifluoromethylaniline1582-09-8216-428-8
14994-Mesyl-2-nitrotoluene1671-49-4430-550-0
1500Triammonium 4-[4-[7-(4-carboxylatoanilino)-1-hydroxy-3-sulfonato-2-naphthylazo]-2,5-dimethoxyphenylazo]benzoate221354-37-6432-270-4
1501Reaction mass of: triammonium 6-amino-3-((2,5-diethoxy-4-(3-phosphonophenyl)azo)phenyl)azo-4-hydroxy-2-naphthalenesulfonate; diammonium 3-((4-((7-amino-1-hydroxy-3-sulfo-naphthalen-2-yl)azo)-2,5-diethoxyphenyl)azo)benzoate163879-69-4438-310-7
1502 N,N′-Diacetylbenzidine613-35-4210-338-2
1503Cyclohexylamine108-91-8203-629-0
1504Piperazine110-85-0203-808-3
1505Hydroxylamine7803-49-8232-259-2
1506Hydroxylammonium chloride; hydroxylamine hydrochloride [1]5470-11-1 [1]226-798-2 [1]
Bis(hydroxylammonium) sulfate; hydroxylamine sulfate (2:1) [2]10039-54-0 [2]233-118-8 [2]
1507Methyl-phenylene diamine; diaminotoluene——
1508Mepanipyrim; 4-methyl-N-phenyl-6-(1-propynyl)-2-pyrimidinamine110235-47-7600-951-7
1509Hydroxylammonium hydrogensulfate; hydroxylamine sulfate(1:1) [1]10046-00-1 [1]233-154-4 [1]
Hydroxylamine phosphate [2]20845-01-6 [2]244-077-0 [2]
Hydroxylamine dihydrogenphosphate [3]19098-16-9 [3]242-818-2 [3]
Hydroxylamine 4-methylbenzenesulfonate [4]53933-48-5 [4]258-872-5 [4]
1510(3-Chloro-2-hydroxypropyl) trimethylammonium chloride3327-22-8222-048-3
1511Biphenyl-3,3′,4,4′-tetrayltetraamine; diaminobenzidine91-95-2202-110-6
1512Piperazine hydrochloride [1]6094-40-2 [1]228-042-7 [1]
Piperazine dihydrochloride [2]142-64-3 [2]205-551-2 [2]
Piperazine phosphate [3]1951-97-9 [3]217-775-8 [3]
15133-(Piperazin-1-yl)-benzo[d]isothiazole hydrochloride87691-88-1421-310-6
15142-Ethylphenylhydrazine hydrochloride19398-06-2421-460-2
1515(2-Chloroethyl)(3-hydroxypropyl)ammonium chloride40722-80-3429-740-6
15164-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1,2-benzenediamine dihydrochloride159939-85-2425-030-5
1517Chloro-N,N-dimethylformiminium chloride3724-43-4425-970-6
15187-Methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one199327-61-2429-400-7
1519Reaction products of diisopropanolamine with formaldehyde (1:4)220444-73-5432-440-8
15203-Chloro-4-(3-fluorobenzyloxy)aniline202197-26-0445-590-4
1521Ethidium bromide; 3,8-diamino-1-ethyl-6-phenylphenantridinium bromide1239-45-8214-984-6
1522(R,S)-2-Amino-3,3-dimethylbutane amide144177-62-8447-860-7
15233-Amino-9-ethyl carbazole; 9-ethylcarbazol-3-ylamine132-32-1205-057-7
1524(6R-trans)-1-((7-Ammonio-2-carboxylato-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-en-3-yl)methyl)pyridinium iodide100988-63-4423-260-0
1525Forchlorfenuron (ISO); 1-(2-chloro-4-pyridyl)-3-phenylurea68157-60-8614-346-0
1526Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one; dimethyl propyleneurea7226-23-5230-625-6
1527Quinoline91-22-5202-051-6
1528Ketoconazole; 1-[4-[4-[[(2SR,4RS)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone65277-42-1265-667-4
1529Metconazole (ISO); (1RS,5RS;1RS,5SR)-5-(4-chlorobenzyl)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol125116-23-6603-031-3
1530Potassium 1-methyl-3-morpholinocarbonyl-4-[3-(1-methyl-3-morpholinocarbonyl-5-oxo-2-pyrazolin-4-ylidene)-1-propenyl]pyrazole-5-olate183196-57-8418-260-2
1531 N,N′,N′-Tris(2-methyl-2,3-epoxypropyl)-perhydro-2,4,6-oxo-1,3,5-triazine26157-73-3435-010-8
1532Trimethylopropane tri(3-aziridinylpropanoate); (TAZ)52234-82-9257-765-0
15334,4′-Methylenediphenyl diisocyanate; diphenylmethane-4,4′-diisocyanate [1]101-68-8 [1]202-966-0 [1]
2,2′-Methylenediphenyl diisocyanate; diphenylmethane-2,2′-diisocyanate [2]2536-05-2 [2]219-799-4 [2]
o-(p-Isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4′-diisocyanate [3]5873-54-1 [3]227-534-9 [3]
Methylenediphenyl diisocyanate [4]26447-40-5 [4]247-714-0 [4]
1534Cinidon ethyl (ISO); ethyl (Z)-2-chloro-3-[2-chloro-5-(cyclohex-1-ene-1,2-dicarboximido)phenyl]acrylate142891-20-1604-318-6
1535 N-[6,9-Dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6-oxo-1H-purin-2-yl]acetamide84245-12-5424-550-1
1536Dimoxystrobin (ISO); (E)-2-(methoxyimino)-N-methyl-2-[α-(2,5-xylyloxy)-o-tolyl]acetamide149961-52-4604-712-8
1537 N,N-(Dimethylamino)thioacetamide hydrochloride27366-72-9435-470-1
1538Reaction mass of: 2,2′-[(3,3′-dichloro[1,1′-biphenyl]-4,4′-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)]-3-oxo-butanamide; 2-[[3,3′-dichloro-4′-[[1[[(2,4-dimethylphenyl)amino]carbonyl]-2-oxopropyl]azo][1,1′-biphenyl]-4-yl]azo]-N-(2-methylphenyl)-3-oxo-butanamide; 2-[[3,3′-dichloro-4′-[[1[[(2,4-dimethylphenyl)amino]carbonyl]-2-oxopropyl]azo][1,1′- biphenyl]-4-yl]azo]-N-(2-carboxylphenyl)-3- oxo-butanamide434-330-5
1539Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or other processing methods if they contain ≥ 0,1 % w/w benzene

85536-20-5

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265-170-2

265-187-5

265-199-0

268-618-5

270-725-7

270-735-1

270-736-7

270-738-8

270-741-4

270-771-8

270-791-7

270-795-9

270-991-4

271-138-9

271-262-3

271-263-9

271-264-4

271-266-5

271-635-0

271-726-5

272-206-0

272-896-3

272-932-8

285-510-3

289-220-8

292-698-0

295-298-4

295-302-4

295-331-2

295-434-2

295-442-6

295-444-7

295-445-2

296-028-8

296-903-4

302-639-3

305-750-5

308-261-5

308-713-1

308-714-7

309-862-5

309-870-9

309-879-8

309-976-5

310-012-0

270-690-8

270-695-5

292-695-4

1540Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or other processing methods if they contain ≥ 0,005 % w/w benzo[a]pyrene

90640-85-0

92061-93-3

90640-84-9

61789-28-4

70321-79-8

122384-77-4

70321-80-1

292-606-9

295-506-3

292-605-3

263-047-8

274-565-9

310-189-4

274-566-4

1541Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or other processing methods if they contain ≥ 0,1 % w/w benzene or if they contain ≥ 0,005 % w/w benzo[a]pyrene

85029-51-2

84650-04-4

84989-09-3

91995-49-2

121620-47-1

121620-48-2

90640-90-7

90641-04-6

101896-27-9

101794-91-6

91995-48-1

90641-05-7

84989-12-8

121620-46-0

90640-81-6

90640-82-7

92061-92-2

91995-15-2

91995-16-3

91995-17-4

101316-87-4

122384-78-5

84988-93-2

90640-88-3

65996-83-0

90640-89-4

90641-06-8

65996-85-2

101316-86-3

92062-22-1

96690-55-0

84989-04-8

84989-05-9

84989-06-0

84989-03-7

84989-07-1

68477-23-6

68555-24-8

91079-47-9

92062-26-5

94114-29-1

90641-00-2

68513-87-1

70321-67-4

92062-29-8

100801-63-6

100801-65-8

100801-66-9

73665-18-6

68815-21-4

65996-86-3

65996-84-1

285-076-5

283-484-8

284-898-1

295-310-8

310-166-9

310-167-4

292-612-1

292-627-3

309-985-4

309-972-3

295-309-2

292-628-9

284-901-6

310-165-3

292-603-2

292-604-8

295-505-8

295-275-9

295-276-4

295-278-5

309-889-2

310-191-5

284-881-9

292-610-0

266-017-2

292-611-6

292-629-4

266-019-3

309-888-7

295-536-7

306-251-5

284-892-9

284-893-4

284-895-5

284-891-3

284-896-0

270-713-1

271-418-0

293-435-2

295-540-9

302-662-9

292-623-1

271-020-7

274-560-1

295-544-0

309-745-9

309-748-5

309-749-0

277-567-8

272-361-4

266-020-9

266-018-8

1542Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or other processing methods if they contain ≥ 0,1 % w/w 1,3-butadiene

68607-11-4

68783-06-2

68814-67-5

68814-90-4

68911-58-0

68911-59-1

68919-01-7

68919-02-8

68919-03-9

68919-04-0

68919-07-3

68919-08-4

68919-11-9

68919-12-0

68952-79-4

68952-80-7

68955-33-9

68989-88-8

92045-15-3

92045-16-4

92045-17-5

92045-18-6

92045-19-7

92045-20-0

68131-75-9

68307-98-2

68307-99-3

68308-00-9

68308-01-0

68308-10-1

68308-03-2

68308-04-3

68308-05-4

68308-06-5

68308-07-6

68308-09-8

68308-11-2

68308-12-3

68409-99-4

68475-57-0

68475-58-1

68475-59-2

68475-60-5

68476-26-6

68476-29-9

68476-40-4

68476-42-6

68476-49-3

68476-85-7

68476-86-8

68477-33-8

68477-35-0

68477-69-0

68477-70-3

68477-71-4

68477-72-5

68308-08-7

271-750-6

272-182-1

272-338-9

272-343-6

272-775-5

272-776-0

272-873-8

272-874-3

272-875-9

272-876-4

272-880-6

272-881-1

272-884-8

272-885-3

273-173-5

273-174-0

273-269-7

273-563-5

295-397-2

295-398-8

295-399-3

295-400-7

295-401-2

295-402-8

268-629-5

269-617-2

269-618-8

269-619-3

269-620-9

269-630-3

269-623-5

269-624-0

269-625-6

269-626-1

269-627-7

269-629-8

269-631-9

269-632-4

270-071-2

270-651-5

270-652-0

270-653-6

270-654-1

270-667-2

270-670-9

270-681-9

270-682-4

270-689-2

270-704-2

270-705-8

270-724-1

270-726-2

270-750-3

270-751-9

270-752-4

270-754-5

269-628-2

1543Tris[2-chloro-1-(chloromethyl)ethyl] phosphate13674-87-8237-159-2
1544Indium phosphide22398-80-7244-959-5
1545Trixylyl phosphate25155-23-1246-677-8
1546Hexabromocyclododecane [1]25637-99-4 [1]247-148-4 [1]
1,2,5,6,9,10-Hexabromocyclododecane [2]3194-55-6 [2]221-695-9 [2]
1547Tetrahydrofuran109-99-9203-726-8
1548Abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]71751-41-2 [1]615-339-5 [1]
Avermectin B1a [2]65195-55-3 [2]265-610-3 [2]
15494-tert-Butylbenzoic acid98-73-7202-696-3
1550Leucomalachite green; N,N,N′,N′-tetramethyl-4,4′-benzylidenedianiline129-73-7204-961-9
1551Fuberidazole (ISO); 2-(2-furyl)-1H-benzimidazole3878-19-1223-404-0
1552Metazachlor (ISO); 2-chloro-N-(2,6-dimethylphenyl)-N-(1H-pyrazol-1-ylmethyl)acetamide67129-08-2266-583-0
1553Di-tert-butyl peroxide110-05-4203-733-6
1554Trichloromethylstannane993-16-8213-608-8
15552-Ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate57583-34-3260-828-5
15562-Ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate15571-58-1239-622-4
1557Sulcotrione (ISO); 2-[2-chloro-4-(methylsulfonyl)benzoyl]cyclohexane-1,3-dione99105-77-8619-394-6
1558Bifenthrin (ISO); (2-methylbiphenyl-3-yl)methyl rel-(1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylate82657-04-3617-373-6
1559Dihexyl phthalate84-75-3201-559-5
1560Ammonium pentadecafluorooctanoate3825-26-1223-320-4
1561Perfluorooctanoic acid335-67-1206-397-9
1562 N-Ethyl-2-pyrrolidone; 1-ethylpyrrolidin-2-one2687-91-4220-250-6
1563Proquinazid (ISO); 6-iodo-2-propoxy-3-propylquinazolin-4(3H)-one189278-12-4606-168-7
1564Gallium arsenide1303-00-0215-114-8
1565Vinyl acetate108-05-4203-545-4
1566Aclonifen (ISO); 2-chloro-6-nitro-3-phenoxyaniline74070-46-5277-704-1
15672-Ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate57583-35-4260-829-0
1568Dimethyltin dichloride753-73-1212-039-2
15694-Vinylcyclohexene100-40-3202-848-9
1570Tralkoxydim (ISO); 2-(N-ethoxypropanimidoyl)-3-hydroxy-5-mesitylcyclohex-2-en-1-one87820-88-0618-075-9
1571Cycloxydim (ISO); 2-(N-ethoxybutanimidoyl)-3-hydroxy-5-(tetrahydro-2H-thiopyran-3-yl)cyclohex-2-en-1-one101205-02-1405-230-9
1572Fluazinam (ISO); 3-chloro-N-[3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl]-5-(trifluoromethyl)pyridin-2-amine79622-59-6616-712-5
1573Penconazole (ISO); 1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole66246-88-6266-275-6
1574Fenoxycarb (ISO); ethyl [2-(4-phenoxyphenoxy)ethyl]carbamate72490-01-8276-696-7
1575Styrene100-42-5202-851-5
1576Tetrahydro-2-furylmethanol; tetrahydrofurfuryl alcohol97-99-4202-625-6
1577Formaldehyde50-00-0200-001-8
1578Paraformaldehyde30525-89-4608-494-5
1579Methanediol; methylene glycol463-57-0207-339-5
1580Cymoxanil (ISO); 2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide57966-95-7261-043-0
1581Tributyltin compounds——
1582Tembotrione (ISO); 2-{2-chloro-4-(methylsulfonyl)-3-[(2,2,2-trifluoroethoxy)methyl]benzoyl}cyclohexane-1,3-dione335104-84-2608-879-8
15831,2-Benzenedicarboxylic acid, dihexyl ester, branched and linear68515-50-4271-093-5
1584Spirotetramat (ISO); (5s,8s)-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4,5]dec-3-en-4-yl ethyl carbonate203313-25-1606-523-6
1585Dodemorph acetate; 4-cyclododecyl-2,6-dimethylmorpholin-4-ium acetate31717-87-0250-778-2
1586Triflusulfuron-methyl; methyl 2-({[4-(dimethylamino)-6-(2,2,2- trifluoroethoxy)-1,3,5-triazin-2- yl]carbamoyl}sulfamoyl)-3- methylbenzoate126535-15-7603-146-9
1587Imazalil (ISO); 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole35554-44-0252-615-0
1588Dodemorph (ISO); 4-cyclododecyl-2,6-dimethylmorpholine1593-77-7216-474-9
1589Imidazole288-32-4206-019-2
1590Lenacil (ISO); 3-cyclohexyl-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione2164-08-1218-499-0
1591Metosulam (ISO); N-(2,6-dichloro-3-methylphenyl)-5,7-dimethoxy[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide139528-85-1604-145-6
15922-Methyl-1-(4-methylthiophenyl)-2-morpholino-propan 1-one71868-10-5400-600-6
15932,3-Epoxypropyl methacrylate; glycidyl methacrylate106-91-2203-441-9
1594Spiroxamine (ISO); 8-tert-butyl-1,4-dioxaspirol[4.5]decan-2-ylmethyl(ethyl)(propyl)amine118134-30-8601-505-4
1595Cyanamide; carbanonitril420-04-2206-992-3
1596Cyproconazole (ISO); (2RS,3RS;2RS,3SR)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol94361-06-5619-020-1
1597Silver zinc zeolite130328-20-0603-404-0
1598Cadmium carbonate513-78-0208-168-9
1599Cadmium hydroxide; cadmium dihydroxide21041-95-2244-168-5
1600Cadmium nitrate; cadmium dinitrate10325-94-7233-710-6
1601Dibutyltin dilaurate; dibutyl[bis(dodecanoyloxy)] stannane77-58-7201-039-8
1602Clorofene; chlorophene; 2-benzyl-4-chlorophenol120-32-1204-385-8
1603Anthraquinone84-65-1201-549-0
1604Nonadecafluorodecanoic acid [1]335-76-2 [1]206-400-3[1]
Ammonium nonadecafluorodecanoate [2]3108-42-7 [2]221-470-5 [2] [3]
Sodium nonadecafluorodecanoate [3]3830-45-3 [3]
1605

N,N′-Methylenedimorpholine; N,N′-methylenebismorpholine; [formaldehyde released from N,N′-Methylenebismorpholine]; [MBM]

if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is ≥ 0,1 % w/w

5625-90-1227-062-3
1606

Reaction products of paraformaldehyde with 2-hydroxypropylamine (3:2); [formaldehyde released from 3,3′-methylenebis[5–methyloxazolidine]; [formaldehyde released from oxazolidin]; [MBO]

if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is ≥ 0,1 % w/w

——
1607

Reaction products of paraformaldehyde with 2-hydroxypropylamine (1:1)); [formaldehyde released from α,α,α-trimethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-triethanol]; [HPT]

if the maximum theoretical concentration of releasable formaldehyde, irrespective of the source, in the mixture as placed on the market is ≥ 0,1 % w/w

——
1608Methylhydrazine60-34-4200-471-4
1609Triadimenol (ISO); (1RS,2RS;1RS,2SR)-1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; α-tert-butyl-β-(4-chlorophenoxy)-1H-1,2,4-triazole-1-ethanol55219-65-3259-537-6
1610Thiacloprid (ISO); (Z)-3-(6-chloro-3-pyridyl-methyl)-1-3-thiazolidin-2-ylidenecyanamide; {(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide111988-49-9601-147-9
1611Carbetamide (ISO); (R)-1-(ethylcarbamoyl) ethyl-carbanilate; (2R)-1-(ethylamino) -1-oxopro-pan-2-yl-phenylcarbamate16118-49-3240-286-6’
(b)

entry 395 is replaced by the following:

Reference numberSubstance identification
Chemical name/INNCAS numberEC number
‘395Hydroxy-8-quinoline and its sulphate

148-24-2

134-31-6

205-711-1

205-137-1’

(2)Annex III is amended as follows:U.K.

(a)

entries 1a, 1b, 7, 13 and 51 are deleted;

(b)

entry 12 is replaced by the following;

a

Directive 2005/36/EC of the European Parliament and of the Council of 7 September 2005 on the recognition of professional qualifications (OJ L 255, 30.9.2005, p. 22).’;

Reference numberSubstance identificationRestrictionsWording of conditions of use and warnings
Chemical name/INNName of Common Ingredients GlossaryCAS numberEC numberProduct type, body partsMaximum concentration in ready for use preparationOther
abcdefghi
‘12

Hydrogen peroxide and other compounds or mixtures that release hydrogen peroxide, including carbamide peroxide and zinc peroxide, with the exception of the following substances in Annex II:

  • No 1397, 1398, 1399

Hydrogen peroxide7722-84-1231-765-0
(a)Hair products
(a)12 % of H2O2 (40 volumes), present or released

(a) (f) Wear suitable gloves

(a) (b) (c) (e)

Contains hydrogen peroxide

Avoid contact with eyes

Rinse immediately if product comes into contact with them.

(b)Skin products
(b)4 % of H2O2, present or released
(c)Nail hardening products
(c)2 % of H2O2, present or released
(d)Oral products, including mouth rinse, tooth paste and tooth whitening or bleaching products
(d)≤ 0,1 % of H2O2, present or released
(e)Tooth whitening or bleaching products
(e)> 0,1 % ≤ 6 % of H2O2, present or released
(e)To be only sold to dental practitioners. For each cycle of use, first use by dental practitioners as defined under Directive 2005/36/EC of the European Parliament and of the Councila or under their direct supervision if an equivalent level of safety is ensured.

Afterwards to be provided to the consumer to complete the cycle of use.

Not to be used on a person under 18 years of age.

(e)Concentration of H2O2 present or released indicated in percentage.

Not to be used on a person under 18 years of age.

To be only sold to dental practitioners. For each cycle of use, the first use to be only done by dental practitioners or under their direct supervision if an equivalent level of safety is ensured.

Afterwards to be provided to the consumer to complete the cycle of use.

(f)Products intended for eyelashes
(f)2 % of H2O2, present or released
(f)For professional use only
f)To be printed on the label:

  • For professional use only.

  • Avoid contact with eyes.

  • Rinse eyes immediately if product comes into contact with them.

  • Contains hydrogen peroxide

(c)

the following entries are added:

Ref No.Substance identificationRestrictionsWording of conditions of use and warnings
Chemical name/INNName of Common Ingredients GlossaryCAS numberEC numberProduct type, body partsMaximum concentration in ready for use preparationOther
abcdefghi
‘311Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxideTrimethylbenzoyl diphenylphosphine oxide75980-60-8278-355-8Artificial nail systems5,0 %Professional use

For professional use only

Avoid skin contact

Read directions for use carefully

3122-FuraldehydeFurfural98-01-1202-627-70,001 %’

(3)Annex V is amended as follows:U.K.

(a)

point 2 of the preamble is replaced by the following:

‘2.All finished products containing substances in this Annex and which release formaldehyde must be labelled with the warning ‘contains formaldehyde’ where the concentration of formaldehyde in the finished product exceeds 0,05 %’

(b)

entries 5, 31, 40 and 41 are deleted;

(c)

entry 28 is replaced by the following:

Reference numberSubstance IdentificationConditionsWording of conditions of use and warnings
Chemical name/INNName of Common Ingredients GlossaryCAS numberEC numberProduct type, Body partsMaximum concentration in ready for use preparationOther
abcdefghi
‘28Polyhexamethylene biguanide hydrochloridePolyaminopropyl biguanide

32289-58-0,

27083-27-8,

28757-47-3,

133029-32-0

608-723-9

608-042-7

0,1 %Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation’
(2)

Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (OJ L 353, 31.12.2008, p. 1).

(3)

Commission Regulation (EU) 2017/776 of 4 May 2017 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (OJ L 116, 5.5.2017, p. 1).

(4)

Commission Regulation (EC) No 790/2009 of 10 August 2009 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (OJ L 235, 5.9.2009, p. 1).

(5)

SCCS/1344/10, http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_077.pdf.

(6)

SCCS/1360/10, http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_053.pdf.

(7)

SCCS/1408/11, https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_118.pdf

(8)

SCCS/1547/15, https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_170.pdf

(9)

Commission Regulation (EU) No 605/2014 of 5 June 2014 amending, for the purposes of introducing hazard and precautionary statements in the Croatian language and its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (OJ L 167, 6.6.2014, p. 36).

(10)

SCCS/1538/14, https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_164.pdf

(11)

SCCS/1345/10, https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_031.pdf

(12)

Commission Regulation (EU) No 618/2012 of 10 July 2012 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (OJ L 179, 11.7.2012, p. 3).

(13)

SCCS/1528/14, http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_149.pdf

(14)

SCCS/1461/12, https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_083.pdf

(15)

Commission Regulation (EU) No 944/2013 of 2 October 2013 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (OJ L 261, 3.10.2013, p. 5).

(16)

SCCS/1535/14, https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_157.pdf

(17)

SCCS/1581/16, https://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_204.pdf

(18)

SCCS/1249/09, https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_027.pdf

(19)

SCCS/1523/13, https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_146.pdf

(20)

SCCS/1483/12, https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_097.pdf