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The Human Organ Transplants (Establishment of Relationship) Regulations 1989
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- UK Statutory Instruments
- 1989 No. 2107
- Regulation 2
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The means by which genetic relationship is to be established
2.—(1) The means by which the fact of a genetic relationship is to be established for the purposes of section 2 of the Human Organ Transplants Act 1989 are the carrying out by a tester of the appropriate tests described in paragraph (2) of this regulation.
(2) The tester shall carry out on the donor and the recipient and on such relatives of each as appear to the tester to be necessary–
(a)tests for the antigenic products of the Human Major Histocompatibility system HLA-A, HLA-B and HLA-DR, using conventional serological techniques, and
(b)tests to establish HLA-DR beta and HLA-DQ beta gene restriction fragment length polymorphisms, and
(c)where the tests in the preceding sub-paragraphs do not establish a genetic relationship between the donor and the recipient, tests to establish DNA polymorphisms, using at least 2 multi-locus gene probes, and
(d)where the tests in the preceding sub-paragraphs do not establish a genetic relationship between the donor and the recipient, further tests to establish DNA polymorphisms, using at least 5 single locus polymorphic probes.
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