Council Regulation (EEC) No 2377/90 (repealed)Dangos y teitl llawn

Council Regulation (EEC) No 2377/90

of 26 June 1990

laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (repealed)

THE COUNCIL OF THE EUROPEAN COMMUNITIES,

Having regard to the Treaty establishing the European Economic Community, and in particular Article 43 thereof,

Having regard to the proposal from the Commission(1),

Having regard to the opinion of the European Parliament(2),

Having regard to the opinion of the Economic and Social Committee(3),

Whereas the use of veterinary medicinal products in food-producing animals may result in the presence of residues of foodstuffs obtained from treated animals;

Whereas as a result of scientific and technical progress it is possible to detect the presence of residues of veterinary medicines in foodstuffs at ever lower levels; whereas it is therefore necessary to establish maximum residue limits for pharmacologically active substances which are used in veterinary medicinal products in respect of all the various foodstuffs of animal origin, including meat, fish, milk, eggs and honey;

Whereas in order to protect public health, maximum residue limits must be established in accordance with generally recognized principles of safety assessment, taking into account any other scientific assessment of the safety of the substances concerned which may have been undertaken by international organizations, in particular the Codex Alimentarius or, where such substances are used for other purposes, by other scientific committees established within the Community;

Whereas the use of veterinary medicinal products plays an important part in agricultural production; whereas the establishment of maximum residue levels will facilitate the marketing of foodstuffs of animal origin;

Whereas the establishment of different maximum residue levels by Member States may hinder the free movement of foodstuffs and of veterinary medicinal products themselves;

Whereas it is therefore necessary to lay down a procedure for the establishment of maximum residue levels of veterinary medicinal products by the Community, following a single scientific assessment of the highest possible quality;

Whereas the need for the establishment of maximum residue levels throughout the Community is recognized in the Community rules relating to trade in foodstuffs of animal origin;

Whereas provisions must be adopted with a view to the systematic establishment of maximum residue levels for new substances capable of pharmacological action intended for administration to food-producing animals;

Whereas arrangements must also be made for the establishment of maximum residue levels for substances which are currently used in veterinary medicines administered to food-producing animals; whereas, however, in view of the complexity of this matter and the large number of substances involved, long transitional arrangements are required;

Whereas, after scientific assessment by the Committee for Veterinary Medicinal Products, maximum residue levels must be adopted by a rapid procedure which ensures close cooperation between the Commission and the Member States through the Committee set up under Council Directive 81/852/EEC of 28 September 1981 on the approximation of the laws of the Member States relating to analytical, pharmaco-toxicological and clinical standards and protocols in respect of the testing of veterinary medicinal products(4), as last amended by Directive 87/20/EEC(5); whereas an urgent procedure is also required to ensure the swift review of any tolerance which might prove insufficient to protect public health;

Whereas medicinally induced immunological responses are usually indistinguishable from those which arise naturally, and do not affect consumers of food of animal origin;

Whereas the information necessary to assess the safety of residues should be presented in accordance with the principles laid down by Directive 81/852/EEC,

HAS ADOPTED THIS REGULATION:

Article 1 U.K.

1. For the purposes of this Regulation, the following definitions shall apply:

(a) ‘residues of veterinary medicinal products’: means all pharmacologically active substances, whether active principles, excipients or degradation products, and their metabolites which remain in foodstuffs obtained from animals to which the veterinary medicinal product in question has been administered;

(b) ‘maximum residue limit’: means the maximum concentration of residue resulting from the use of a veterinary medicinal product (expressed in mg/kg or μg/kg on a fresh weight basis) which may be accepted by the Community to be legally permitted or recognized as acceptable in or on a food.

It is based on the type and amount of residue considered to be without any toxicological hazard for human health as expressed by the acceptable daily intake (ADI), or on the basis of a temporary ADI that utilizes an additional safety factor. It also takes into account other relevant public health risks as well as food technology aspects.

When establishing a maximum residue limit (MRL), consideration is also given to residues that occur in food of plant origin and/or come from the environment. Furthermore, the MRL may be reduced to be consistent with good practices in the use of veterinary drugs and to the extent that practical analytical methods are available.

2. This Regulation shall not apply to active principles of biological origin intended to produce active or passive immunity or to diagnose a state of immunity used in immunological veterinary medicinal products.

Article 2 U.K.

The list of pharmacologically active substances used in veterinary medicinal products in respect of which maximum residue limits have been established shall be contained in Annex I, which shall be adopted in accordance with the procedure laid down in Article 8. Except as provided for in Article 9, any amendments to Annex I shall be adopted in accordance with the same procedure.

Article 3 U.K.

Where, following an evaluation of a pharmacologically active substance used in veterinary medicinal products, it appears that it is not necessary for the protection of public health to establish a maximum residue limit, that substance shall be included in a list in Annex II, which shall be adopted in accordance with the procedure laid down in Article 8. Except as provided for in Article 9, any amendments to Annex II shall be adopted in accordance with the same procedure.

Article 4 U.K.

A provisional maximum residue limit may be established for a pharmacologically active substance used in veterinary medicinal products on the date of entry into force of this Regulation, provided that there are no grounds for supposing that residues of the substance concerned at the level proposed present a hazard for the health of the consumer. A provisional maximum residue limit shall apply for a defined period of time, which shall not exceed five years. That period may be extended once only in exceptional cases for a period not in excess of two years if that proves expedient for the completion of scientific studies in progress.

In exceptional circumstances, a provisional maximum residue limit may also be established for a pharmacologically active substance not previously used in veterinary medicinal products on the date of entry into force of this Regulation provided that there are no grounds for supposing that residues of the substance concerned at the limit proposed present a hazard for the health of the consumer.

The list of pharmacologically active substances used in veterinary medicinal products in respect of which provisional maximum residue limits have been established shall be contained in Annex III, which shall be adopted in accordance with the procedure laid down in Article 8. Except as provided for in Article 9, any amendments to Annex III shall be adopted in accordance with the same procedure.

Article 5 U.K.

Where it appears that a maximum residue limit cannot be established in respect of a pharmacologically active substance used in veterinary medicinal products because residues of the substances concerned, at whatever limit, in foodstuffs of animal origin constitute a hazard to the health of the consumer, that substance shall be included in a list in Annex IV, which shall be adopted in accordance with the procedure laid down in Article 8. Except as provided for in Article 9, any amendments to Annex IV shall be adopted in accordance with the same procedure.

The administration of the substances listed in Annex IV to food-producing animals shall be prohibited throughout the Community.

[F1 Article 6 U.K.

1. In order to obtain the inclusion in Annexes I, II or III of a pharmacologically active substance which is intended for use in veterinary medicinal products for administration to food-producing animals, an application to establish a maximum residue limit shall be submitted to the European Agency for the Evaluation of Medicinal Products set up by Council Regulation (EEC) No 2309/93 (6) , hereinafter referred to as ‘the Agency’.

This application shall contain the information and particulars referred to in Annex V of this Regulation and shall conform with the principles laid down in Directive 81/852/EEC.

2. The application shall also be accompanied by the fee payable to the Agency.

Textual Amendments

F1 Substituted by Council Regulation (EC) No 1308/1999 of 15 June 1999 amending Regulation (EC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

Article 7 U.K.

1. The Committee for Veterinary Medicinal Products referred to in Article 27 of Regulation (EC) No 2309/93 (hereinafter ‘ the Committee ’ ) shall be responsible for formulating the Agency's opinion on the classification of substances referred to in Annexes I, II, III or IV to this Regulation.

2. Articles 52 and 53 of Regulation (EEC) No 2309/93 shall be applicable for the purposes of this Regulation.

3. The Agency shall ensure that the Committee's opinion is delivered within a period of 120 days following the reception of a valid application.

If the information submitted by the applicant is not sufficient to enable such an opinion to be prepared, the Committee may ask the applicant to supply additional information within a specific time limit. The deadline for the opinion shall then be deferred until the additional information has been received.

4. The Agency shall forward the opinion to the applicant. Within 15 days of receipt of the opinion, the applicant may provide written notice to the Agency that he wishes to appeal. In that case he shall forward the detailed grounds for his appeal to the Agency within 60 days of receipt of the opinion. Within 60 days of the receipt of the grounds for appeal, the Committee shall consider whether its opinion should be revised and the reasons for the conclusion reached on the appeal shall be annexed to the report referred to in paragraph 5.

5. The Agency shall forward the definitive opinion of the Committee within 30 days of its adoption both to the Commission and to the applicant. The opinion shall be accompanied by a report describing the safety evaluation of the substance by the Committee, which shall give the grounds for its conclusions.

6. The Commission shall prepare draft measures taking account of Community legislation and shall start the procedure provided for in Article 8. The Committee referred to in Article 8 shall adapt its rules of procedure in order to take account of the tasks conferred on it by this Regulation.]

Textual Amendments

F1 Substituted by Council Regulation (EC) No 1308/1999 of 15 June 1999 amending Regulation (EC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

[F2 Article 8 U.K.

1. The Commission shall be assisted by the Standing Committee on Veterinary Medicinal Products.

2. Where reference is made to this Article, Articles 5 and 7 of Decision 1999/468/EC (7) shall apply.

The period laid down in Article 5(6) of Decision 1999/468/EC shall be set at three months.

3. The Standing Committee shall adopt its Rules of Procedure.]

Textual Amendments

F2 Substituted by Council Regulation (EC) No 806/2003 of 14 April 2003 adapting to Decision 1999/468/EC the provisions relating to committees which assist the Commission in the exercise of its implementing powers laid down in Council instruments adopted in accordance with the consultation procedure (qualified majority).

Article 9 U.K.

1. Where a Member State, as a result of new information or a reassessment of existing information, considers that the urgent amendment of a provision contained in Annexes I to IV is necessary in order to protect human or animal health, and therefore requires swift action to be taken, that Member State may temporarily suspend the operation of the provision concerned in its own territory. In that case, it shall immediately notify the other Member States and the Commission of the measures, attaching a statement of the reasons therefor.

2. [F1 The Commission shall as soon as possible examine the grounds given by the Member State concerned and, after consulting the Committee for Veterinary Medicinal Products, it shall then deliver its opinion forthwith and take appropriate measures; the person responsible for marketing may be requested to provide the Committee with oral or written explanations]. The Commission shall immediately notify the Council and the Member States of any measures taken. Any Member State may refer the Commission's measures to the Council within 15 days of such notification. The Council, acting by a qualified majority, may take a different decision within 30 days of the date on which the matter was referred to it.

3. If the Commission considers that it is necessary to amend the provision of Annex I to IV concerned in order to resolve the difficulties referred to in paragraph 1 and to ensure the protection of human health, it shall initiate the procedure laid down in Article 10 with a view to adopting those amendments; the Member State which has taken measures under paragraph 1 may maintain them until the Council or the Commission has taken a decision in accordance with the abovementioned procedure.

Textual Amendments

F1 Substituted by Council Regulation (EC) No 1308/1999 of 15 June 1999 amending Regulation (EC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

[F2 Article 10 U.K.

1. The Commission shall be assisted by the Standing Committee on Veterinary Medicinal Products.

2. Where reference is made to this Article, Articles 5 and 7 of Decision 1999/468/EC shall apply.

The period laid down in Article 5(6) of Decision 1999/468/EC shall be set at 15 days.]

Textual Amendments

F2 Substituted by Council Regulation (EC) No 806/2003 of 14 April 2003 adapting to Decision 1999/468/EC the provisions relating to committees which assist the Commission in the exercise of its implementing powers laid down in Council instruments adopted in accordance with the consultation procedure (qualified majority).

Article 11 U.K.

Any changes which are necessary to adapt Annex V to take account of scientific and technical progress shall be adopted in accordance with the procedure laid down in Article 2c of Directive 81/852/EEC.

[F1 Article 12 U.K.

As soon as possible after the amendment of Annexes I, II, III or IV, the Commission shall publish a summary of the assessment of the safety of the substances concerned that have been examined by the Committee for Veterinary Medicinal Products. The confidential nature of any proprietary data shall be respected. The Agency shall provide the competent authorities and the Commission with appropriate methods for identifying pharmacologically active substances for which the MRL's have been determined in [X1 Annexes I and III.] ]

Editorial Information

X1 Substituted by Corrigendum to Council Regulation (EC) No 1308/1999 of 15 June 1999 amending Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Official Journal of the European Communities L 156 of 23 June 1999).

Textual Amendments

F1 Substituted by Council Regulation (EC) No 1308/1999 of 15 June 1999 amending Regulation (EC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

Article 13 U.K.

Member States may not prohibit or impede the putting into circulation within their territories of foodstuffs of animal origin originating in other Member States on the grounds that they contain residues of veterinary medicinal products if the quantity of residue does not exceed the maximum residue limit provided for in Annex I or III, or if the substance concerned is listed in Annex II.

Article 14 U.K.

With effect from 1 January 1997, the administration to food-producing animals of veterinary medicinal products containing pharmacologically active substances which are not mentioned in Annexes I, II or III shall be prohibited within the Community, except in the case of clinical trials accepted by the competent authorities following notification or authorization in accordance with the legislation in force and which do not cause foodstuffs obtained from livestock participating in such trials to contain residues which constitute a hazard to human health.

[F3 However, the date referred to in the previous subparagraph shall be deferred for substances the use of which was authorized on the date of entry into force of this Regulation and in respect of which documented applications for the establishment of maximum residue limits have been lodged with the Commission or with the European Agency for the Evaluation of Medicinal Products before 1 January 1996 :

• [F1 until 1 January 1998 in the case of pyrazolinones (including pyrazolidinediones and phenylbutazones), nitroimidazoles and arsalinic acid, and]

• until 1 January 2000 in the case of other substances.

The Agency shall publish a list of these substances before 7 June 1997 .]

Textual Amendments

F1 Substituted by Council Regulation (EC) No 1308/1999 of 15 June 1999 amending Regulation (EC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

F3 Inserted by Council Regulation (EC) No 434/97 of 3 March 1997 amending Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

Article 15 U.K.

This Regulation shall in no way prejudice the application of Community legislation prohibiting the use in livestock farming of certain substances having a hormonal action.

Nothing in this Regulation shall prejudice the measures taken by Member States to prevent the unauthorized use of veterinary medicinal products.

Article 16 U.K.

This Regulation shall enter into force on 1 January 1992.

This Regulation shall be binding in its entirety and directly applicable in all Member States.

[F4 ANNEX I U.K. LIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES FOR WHICH MAXIMUM RESIDUE LIMITS HAVE BEEN FIXED

Textual Amendments

F4 Substituted by Commission Regulation (EC) No 508/1999 of 4 March 1999 amending Annexes I to IV to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

1. Anti-infectious agents U.K.

1.1. Chemotheurapeutics U.K.

1.1.1. Sulfonamides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
All substances belonging to the sulfonamide group	Parent drug	All food-producing species	100 μg/kg	Muscle	The combined total residues of all substances within the sulfonamide group should not exceed 100 μg/kg
			100 μg/kg	Fat
			100 μg/kg	Liver
			100 μg/kg	Kidney
		Bovine, ovine, caprine	100 μg/kg	Milk

1.1.2. Diamino pyrimidine derivatives U.K.

a [F5 For porcine and poultry species this MRL relates to ‘ skin and fat in natural proportions ’ .
b For fin fish this MRL relates to ‘ muscle and skin in natural proportions ’ .]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Baquiloprim	Baquiloprim	Bovine	10 μg/kg	Fat
			300 μg/kg	Liver
			150 μg/kg	Kidney
			30 μg/kg	Milk
		Porcine	40 μg/kg	Skin and fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
[F6 Trimethoprim	Trimethoprim	All food producing species except equidae	50 μg/kg	Fat a	Not for use in animals from which eggs are produced for human consumption
			50 μg/kg	Muscle  b
			50 μg/kg	Liver
			50 μg/kg	Kidney
			50 μg/kg	Milk
		Equidae	100 μg/kg	Muscle
			100 μg/kg	Fat
			100 μg/kg	Liver
			100 μg/kg	Kidney]

Textual Amendments

F5 Inserted by Commission Regulation (EC) No 1181/2002 of 1 July 2002 amending Annex I of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F6 Substituted by Commission Regulation (EC) No 1181/2002 of 1 July 2002 amending Annex I of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

1.2. Antibiotics U.K.

1.2.1. Penicillins U.K.

a [F7 For intramammary use only.]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Amoxicyllin	Amoxicyllin	All food-producing species	50 μg/kg	Muscle
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			4 μg/kg	Milk
Ampicillin	Ampicillin	All food-producing species	50 μg/kg	Muscle
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			4 μg/kg	Milk
Benzylpenicillin	Benzylpenicillin	All food-producing species	50 μg/kg	Muscle
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			4 μg/kg	Milk
Cloxacillin	Cloxacillin	All food-producing species	300 μg/kg	Muscle
			300 μg/kg	Fat
			300 μg/kg	Liver
			300 μg/kg	Kidney
			30 μg/kg	Milk
Dicloxacillin	Dicloxacillin	All food-producing species	300 μg/kg	Muscle
			300 μg/kg	Fat
			300 μg/kg	Liver
			300 μg/kg	Kidney
			30 μg/kg	Milk
[F8 Nafcillin	Nafcillin	All ruminants a	300 µg/kg	Muscle
			300 µg/kg	Fat
			300 µg/kg	Liver
			300 µg/kg	Kidney
			30 µg/kg	Milk]
Oxacillin	Oxacillin	All food-producing species	300 μg/kg	Muscle
			300 μg/kg	Fat
			300 μg/kg	Liver
			300 μg/kg	Kidney
			30 μg/kg	Milk
Penethamate	Benzylpenicillin	Bovine	50 μg/kg	Muscle
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			4 μg/kg	Milk
[F9		Porcine	50 μg/kg	Muscle
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney	]
[F10 Phenoxymethylpenicillin	Phenoxymethylpenicillin	Porcine	25 μg/kg	Muscle
			25 μg/kg	Liver
			25 μg/kg	Kidney	]

Textual Amendments

F7 Inserted by Commission Regulation (EC) No 546/2004 of 24 March 2004 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F8 Substituted by Commission Regulation (EC) No 546/2004 of 24 March 2004 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F9 Inserted by Commission Regulation (EC) No 2757/1999 of 22 December 1999 amending Annexes I and II of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F10 Inserted by Commission Regulation (EC) No 1286/2000 of 19 June 2000 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

1.2.2. Cephalosporins U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F11 Cefacetrile	Cefacetrile	Bovine	125 μg/kg	Milk	For intramammary use only]
[F12 Cefalexin	Cefalexin	Bovine	200 μg/kg	Muscle
			200 μg/kg	Fat
			200 μg/kg	Liver
			1 000  μg/kg	Kidney
			100 μg/kg	Milk	]
[F13 Cefalonium	Cefalonium	Bovine	20 μg/kg	Milk	]
[F14 Cefapirin	Sum of cephapirin and desacetylcephapirin	Bovine	50 μg/kg	Muscle
			50 μg/kg	Fat
			100 μg/kg	Kidney
			60 μg/kg	Milk	]
Cefazolin	Cefazolin	Bovine, ovine, caprine	50 μg/kg	Milk
[F15 Cefoperazone	Cefoperazone	Bovine	50 μg/kg	Milk	]
Cefquinome	Cefquinome	Bovine	50 μg/kg	Muscle
			50 μg/kg	Fat
			100 μg/kg	Liver
			200 μg/kg	Kidney
			20 μg/kg	Milk
[F16		Porcine	50 μg/kg	Muscle
			50 μg/kg	Skin + fat
			100 μg/kg	Liver
			200 μg/kg	Kidney	]
[F17		Equidae	50 μg/kg	Muscle
			50 μg/kg	Fat
			100 μg/kg	Liver
			200 μg/kg	Kidney	]
[F18 Ceftiofur	Sum of all residues retaining the betalactam structure expressed as desfuroylceftiofur	Bovine	1 000 μg/kg	Muscle
			2 000 μg/kg	Fat
			2 000 μg/kg	Liver
			6 000 μg/kg	Kidney
			100 μg/kg	[F19 Milk]
		Porcine	1 000 μg/kg	Muscle
			2 000 μg/kg	Fat
			2 000 μg/kg	Liver
			6 000 μg/kg	Kidney	]

Textual Amendments

F11 Inserted by Commission Regulation (EC) No 2162/2001 of 7 November 2001 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F12 Inserted by Commission Regulation (EC) No 2728/1999 of 20 December 1999 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F13 Inserted by Commission Regulation (EC) No 61/2003 of 15 January 2003 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F14 Inserted by Commission Regulation (EC) No 1553/2001 of 30 July 2001 amending Annex I to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F15 Inserted by Commission Regulation (EC) No 807/2001 of 25 April 2001 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F16 Inserted by Commission Regulation (EC) No 1931/1999 of 9 September 1999 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F17 Inserted by Commission Regulation (EC) No 2145/2003 of 8 December 2003 amending Annex I to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F18 Inserted by Commission Regulation (EC) No 804/1999 of 16 April 1999 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F19 Substituted by Commission Regulation (EC) No 1752/2002 of 1 October 2002 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

1.2.3. Quinolones U.K.

a [F5 For fin fish this MRL relates to ‘ muscle and skin in natural proportions ’ .
b For porcine species this MRL relates to ‘ skin and fat in natural proportions ’ .]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F6 Danofloxacin	Danofloxacin	[X2 All food producing species except bovine, ovine, caprine, porcine and poultry]	100 μg/kg	Muscle b
			50 μg/kg	Fat a
			200 μg/kg	Liver
			200 μg/kg	Kidney
		Bovine, ovine, caprine	200 μg/kg	Muscle
			100 μg/kg	Fat
			400 μg/kg	Liver
			400 μg/kg	Kidney
			30 μg/kg	Milk
		Poultry	200 μg/kg	Muscle	Not for use in animals from which eggs are produced for human consumption
			100 μg/kg	Skin and fat
			400 μg/kg	Liver
			400 μg/kg	Kidney
Difloxacin	Difloxacin	All food producing species except bovine, ovine, caprine and poultry	300 μg/kg	Muscle b
			100 μg/kg	Fat
			800 μg/kg	Liver
			600 μg/kg	Kidney
		Bovine, ovine, caprine	400 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			100 μg/kg	Fat
			1 400  μg/kg	Liver
			800 μg/kg	Kidney
		Porcine	400 μg/kg	Muscle
			100 μg/kg	Skin and fat
			800 μg/kg	Liver
			800 μg/kg	Kidney
		Poultry	300 μg/kg	Muscle	Not for use in animals from which eggs are produced for human consumption
			400 μg/kg	Skin and fat
			1 900  μg/kg	Liver
			600 μg/kg	Kidney
Enrofloxacin	Sum of enrofloxacin and ciprofloxacin	All food producing species except bovine, ovine, caprine, porcine, rabbits and poultry	100 μg/kg	Muscle b
			100 μg/kg	Fat
			200 μg/kg	Liver
			200 μg/kg	Kidney
		Bovine, ovine, caprine	100 μg/kg	Muscle
			100 μg/kg	Fat
			300 μg/kg	Liver
			200 μg/kg	Kidney
			100 μg/kg	Milk
		Porcine, rabbits	100 μg/kg	Muscle
			100 μg/kg	Fat a
			200 μg/kg	Liver
			300 μg/kg	Kidney
		Poultry	100 μg/kg	Muscle	Not for use in animals from which eggs are produced for human consumption
			100 μg/kg	Skin and fat
			200 μg/kg	Liver
			300 μg/kg	Kidney
Flumequine	Flumequine	All food producing species except bovine, ovine, caprine, porcine, poultry and fin fish	200 μg/kg	Muscle
			250 μg/kg	Fat
			500 μg/kg	Liver
			1 000  μg/kg	Kidney
		Bovine, porcine, ovine, caprine	200 μg/kg	Muscle
			300 μg/kg	Fat a
			500 μg/kg	Liver
			1 500  μg/kg	Kidney
			50 μg/kg	Milk
		Poultry	400 μg/kg	Muscle	Not for use in animals from which eggs are produced for human consumption
			250 μg/kg	Skin and fat
			800 μg/kg	Liver
			1 000  μg/kg	Kidney
		Fin fish	600 μg/kg	Muscle and skin in natural proportion	]
[F20 Marbofloxacin	Marbofloxacin	Bovine	150 μg/kg	Muscle
			50 μg/kg	Fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
			75 μg/kg	Milk
		Porcine	150 μg/kg	Muscle
			50 μg/kg	Skin and fat
			150 μg/kg	Liver
			150 μg/kg	Kidney	]
[F21 Oxolinic acid	Oxolinic acid	Porcine	100 μg/kg	Muscle
			50 μg/kg	Skin and fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
		Chicken	100 μg/kg	Muscle	Not for use in animals from which eggs are produced for human consumption
			50 μg/kg	Skin and fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
		Fin fish	100 μg/kg	Muscle and skin in natural proportions	]
Sarafloxacin	Sarafloxacin	Chicken	10 μg/kg	Skin and fat
			100 μg/kg	Liver
		Salmonidae	30 μg/kg	Muscle and skin in natural proportions

Editorial Information

X2 Substituted by Corrigendum to Commission Regulation (EC) No 1181/2002 of 1 July 2002 amending Annex I of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Official Journal of the European Communities L 172 of 2 July 2002).

Textual Amendments

F20 Inserted by Commission Regulation (EC) No 2338/2000 of 20 October 2000 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F21 Inserted by Commission Regulation (EC) No 739/2003 of 28 April 2003 amending Annex I to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

1.2.4. Macrolides U.K.

a [F5 For fin fish this MRL relates to a ‘ muscle and skin in natural proportions ’ .
b For procine species this MRL relates to ‘ skin and fat in natural proportions ’ .
c For porcine and poultry species this MRL relates to ‘ skin and fat in natural proportions ’ .
d [F22 [X3 Not for use in animals from which milk is produced for human consumption.] ] ]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F23 Acetylisovaleryltylosin	Sum of acetyl-isovaleryltylosin and 3-O-acetyltylosin	Porcine	50 μg/kg	Muscle
			50 μg/kg	Skin and fat
			50 μg/kg	Liver
			50 μg/kg	Kidney	]
[F6 Erythromycin	Erythromicyin A	All food producing species	200 μg/kg	Muscle  a
			200 μg/kg	Fat  b
			200 μg/kg	Liver
			200 μg/kg	Kidney
			40 μg/kg	Milk
			150 μg/kg	Eggs	]
Spiramycin	Sum of spiramycin and neospiramycin	Bovine	200 μg/kg	Muscle
			300 μg/kg	Fat
			300 μg/kg	Liver
			300 μg/kg	Kidney
			200 μg/kg	Milk
		Chicken	200 μg/kg	Muscle
			300 μg/kg	Skin and fat
			400 μg/kg	Liver
[F24	Spiramycin 1	Porcine	250 μg/kg	Muscle
			2 000  μg/kg	Liver
			1 000  μg/kg	Kidney	]
[F6 Tilmicosin	Tilmicosin	All food producing species except poultry	50 μg/kg	Muscle  a
			50 μg/kg	Fat  b
			1 000  μg/kg	Liver
			1 000  μg/kg	Kidney
			50 μg/kg	Milk
		Poultry	75 μg/kg	Muscle	Not for use in animals from which eggs are produced for human consumption
			75 μg/kg	Sin and fat
			1 000  μg/kg	Liver
			250 μg/kg	Kidney
[F22 [X3 Tulathromycin	(2R,3S,4R,5R,8R,10R,11R,12S, 13S,14R)-2-ethyl-3,4,10,13-tetrahydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-ß-D-xylo-hexopy-ranosyl]oxy]-1-oxa-6-azacyclopent-decan-15-one expressed as tulathromycin equivalents	Bovine d	100  μg/kg	Fat
			3 000  μg/kg	Liver
			3 000  μg/kg	Kidney
		Porcine	100  μg/kg	Skin + fat
			3 000  μg/kg	Liver
			3 000  μg/kg	Kidney	] ]
Tylosin	Tylosin A	All food producing species	100 μg/kg	Fat  c
			100 μg/kg	Muscle  a
			100 μg/kg	Liver
			100 μg/kg	Kidney
			50 μg/kg	Milk
			200 μg/kg	Eggs	]

Editorial Information

X3 Substituted by Corrigendum to Commission Regulation (EC) No 1101/2004 of 10 June 2004 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Official Journal of the European Union L 211 of 12 June 2004).

Textual Amendments

F22 Inserted by Commission Regulation (EC) No 1101/2004 of 10 June 2004 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F23 Inserted by Commission Regulation (EC) No 77/2002 of 17 January 2002 amending Annexes I and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F24 Inserted by Commission Regulation (EC) No 2593/1999 of 8 December 1999 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

1.2.5. Florfenicol and related compounds U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F6 Florfenicol	Sum of florfenicol and its metabolites measured as florfenicol-amine	All food producing species except bovine, ovine, caprine, porcine, poultry and fin fish	100 μg/kg	Muscle
			200 μg/kg	Fat
			2 000  μg/kg	Liver
			300 μg/kg	Kidney
		Bovine, ovine, caprine	200 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			[X4 3 000 μg/kg]	[X4 Liver]
			300 μg/kg	Kidney
		Porcine	300 μg/kg	Muscle
			500 μg/kg	Skin and fat
			2 000  μg/kg	Liver
			500 μg/kg	Kidney
		Poultry	100 μg/kg	Muscle	Not for use in animals from which eggs are produced for human consumption
			200 μg/kg	Skin and fat
			2 500  μg/kg	Liver
			750 μg/kg	Kidney
		Fin fish	1 000  μg/kg	Muscle and skin in natural proportions	]
Thiamphenicol	Thiamphenicol	Bovine	50 μg/kg	Muscle
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			50 μg/kg	Milk
		Chicken	50 μg/kg	Muscle
		Not for use in animals from which eggs are produced for human consumption	50 μg/kg	Skin and fat
			50 μg/kg	Liver
			50 μg/kg	Kidney

Editorial Information

X4 Substituted by Corrigendum to Commission Regulation (EC) No 1181/2002 of 1 July 2002 amending Annex I of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Official Journal of the European Communities L 172 of 2 July 2002).

1.2.6. Tetracyclines U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Chlortetracycline	Sum of parent drug and its 4- epimer	All food-producing species	100 μg/kg	Muscle
			300 μg/kg	Liver
			600 μg/kg	Kidney
			100 μg/kg	Milk
			200 μg/kg	Eggs
Doxycycline	Doxycycline	Bovine	100 μg/kg	Muscle
		Not for use in animals from which milk is produced for human consumption	300 μg/kg	Liver
			600 μg/kg	Kidney
		Porcine	100 μg/kg	Muscle
			300 μg/kg	Skin and fat
			300 μg/kg	Liver
			600 μg/kg	Kidney
		Poultry	100 μg/kg	Muscle
		Not for use in animals from which eggs are produced for human consumption	300 μg/kg	Skin and fat
			300 μg/kg	Liver
			600 μg/kg	Kidney
Oxytetracycline	Sum of parent drug and its 4-epimer	All food-producing species	100 μg/kg	Muscle
			300 μg/kg	Liver
			600 μg/kg	Kidney
			100 μg/kg	Milk
			200 μg/kg	Eggs
Tetracycline	Sum of parent drug and its 4-epimer	All food-producing species	100 μg/kg	Muscle
			300 μg/kg	Liver
			600 μg/kg	Kidney
			100 μg/kg	Milk
			200 μg/kg	Eggs

1.2.7. Naphtalene-ringed ansamycin U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Rifaximin	Rifaximin	Bovine	60 μg/kg	Milk

1.2.8. Pleuromutilines U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F12 Tiamulin	Sum of metabolites that may be hydrolysed to 8-a-hydroxymutilin	Porcine	100 μg/kg	Muscle
			500 μg/kg	Liver
		Chicken	100 μg/kg	Muscle
			100 μg/kg	Skin and fat
			1 000  μg/kg	Liver
		[F20 Rabbits	100 μg/kg	Muscle
			500 μg/kg	Liver	]
		[F15 Turkey	100 μg/kg	Muscle
			100 μg/kg	Skin and fat
			300 μg/kg	Liver	]
	Tiamulin		1 000  μg/kg	Eggs	]
Valnemulin	Valnemulin	Porcine	50 μg/kg	Muscle
			500 μg/kg	Liver
			100 μg/kg	Kidney

[F18 1.2.9. Lincosamides U.K.

a [F5 For porcine and poultry species this MRL relates to ‘ skin and fat in natural proportions ’ .
b For fin fish this MRL relates to ‘ muscle and skin in natural proportions ’ .] ]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F6 Lincomycin	Lincomicyn	All food producing species	50 μg/kg	Fat  a
			100 μg/kg	Muscle  b
			500 μg/kg	Liver
			1 500  μg/kg	Kidney
			150 μg/kg	Milk
			50 μg/kg	Eggs	]
[F20 Pirlimycin	Pirlimycin	Bovine	100 μg/kg	Muscle
			100 μg/kg	Fat
			1 000  μg/kg	Liver
			400 μg/kg	Kidney
			100 μg/kg	Milk
		Porcine	100 μg/kg	Muscle
			50 μg/kg	Skin and fat
			500 μg/kg	Liver
			1 500  μg/kg	Kidney
		Chicken	100 μg/kg	Muscle
			50 μg/kg	Skin and fat
			500 μg/kg	Liver
			1 500  μg/kg	Kidney
			50 μg/kg	Eggs	]

[F16 1.2.10. Aminoglycosides U.K.

a [F5 For porcine and poultry species this MRL relates to ‘ skin and fat in natural proportions ’ .
b For fin fish this MRL relates to ‘ muscle and skin in natural proportions ’ .
c [F25 Not for use in animals from which eggs are produced for human consumption.] ] ]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Apramycin	Apramycin	Bovine	1 000  μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			1 000  μg/kg	Fat
			10 000  μg/kg	Liver
			20 000  μg/kg	Kidney
[F26 Dihydrostreptomycin	Dihydrostreptomycin	Bovine, ovine	500 μg/kg	Muscle
			500 μg/kg	Fat
			500 μg/kg	Liver
			1 000  μg/kg	Kidney
			200 μg/kg	Milk
		Porcine	500 μg/kg	Muscle
			500 μg/kg	Skin and fat
			500 μg/kg	Liver
			1 000  μg/kg	Kidney	]
[F27 Gentamicin	Sum of gentamicin C1, gentamicin C1a, gentamicin C2 and gentamicin C2a	Bovine	50 μg/kg	Muscle
			50 μg/kg	Fat
			200 μg/kg	Liver
			750 μg/kg	Kidney
			100 μg/kg	Milk
		Porcine	50 μg/kg	Muscle
			50 μg/kg	Skin and fat
			200 μg/kg	Liver
			750 μg/kg	Kidney	]
[F25 Kanamycin	Kanamycin A	All food producing species except fish c	100 μg/kg	Muscle
			100 μg/kg	Fat a
			600 μg/kg	Liver
			2 500  μg/kg	Kidney
			150 μg/kg	Milk	]
[F5 Neomycin (including framycetin)	Neomycin B	All food producing species	500 μg/kg	Fat  a
			500 μg/kg	Muscle  b
			500 μg/kg	Liver
			5 000  μg/kg	Kidney
			1 500  μg/kg	Milk
			500 μg/kg	Eggs	]
[F6 Paromomycin	Paromomycin	All food producing species	500 μg/kg	Muscle b	Not for use in animals from which milk or eggs are produced for human consumption
			1 500  μg/kg	Liver
			1 500  μg/kg	Kidney
Spectinomycin	Spectinomycin	All food producing species except ovine	500 μg/kg	Fat a	Not for use in animals from which eggs are produced for human consumption
			300 μg/kg	Muscle  b
			1 000  μg/kg	Liver
			5 000  μg/kg	Kidney
			200 μg/kg	Milk
		Ovine	300 μg/kg	Muscle
			500 μg/kg	Fat
			2 000  μg/kg	Liver
			5 000  μg/kg	Kidney
			200 μg/kg	Milk]
[F26 Streptomycin	Streptomycin	Bovine, ovine	500 μg/kg	Muscle
			500 μg/kg	Fat
			500 μg/kg	Liver
			1 000  μg/kg	Kidney
			200 μg/kg	Milk
		Porcine	500 μg/kg	Muscle
			500 μg/kg	Skin and fat
			500 μg/kg	Liver
			1 000  μg/kg	Kidney	]

Textual Amendments

F25 Inserted by Commission Regulation (EC) No 324/2004 of 25 February 2004 amending Annex I to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F26 Inserted by Commission Regulation (EC) No 1530/2002 of 27 August 2002 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F27 Inserted by Commission Regulation (EC) No 868/2002 of 24 May 2002 amending Annexes I and II of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F24 1.2.11. Other antibiotics U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Novobiocin	Novobiocin	Bovine	50 μg/kg	Milk	]

[F28 1.2.12. Polypeptides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Bacitracin	Sum of bacitracin A, bacitracin B, and bacitracin C	Bovine	100 μg/kg	Milk
[F29		Rabbits	150 μg/kg	Muscle
			150 μg/kg	Fat
			150 μg/kg	Liver
			150 μg/kg	Kidney	] ]

Textual Amendments

F29 Inserted by Commission Regulation (EC) No 544/2003 of 27 March 2003 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

Textual Amendments

F28 Inserted by Commission Regulation (EC) No 1478/2001 of 18 July 2001 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F14 1.2.13. Beta-lactamase inhibitors U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Clavulanic acid	Clavulanic acid	Bovine	100 μg/kg	Muscle
			100 μg/kg	Fat
			200 μg/kg	Liver
			400 μg/kg	Kidney
			200 μg/kg	Milk
		Porcine	100 μg/kg	Muscle
			100 μg/kg	Skin and fat
			200 μg/kg	Liver
			400 μg/kg	Kidney	]

[F5 1.2.14. Polymyxins U.K.

a For porcine and poultry species this MRL relates to ‘ skin and fat in natural proportions ’ .
b For fin fish this MRL relates to ‘ muscle and skin in natural proportions ’ .]
Pharmacologically active substance	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Colistin	Colistin	All food producing species	150 μg/kg	Fat  a
			150 μg/kg	Muscle  b
			150 μg/kg	Liver
			200 μg/kg	Kidney
			50 μg/kg	Milk
			300 μg/kg	Eggs

2. Antiparasitic agents U.K.

2.1. Agents acting against endoparasites U.K.

2.1.1. Salicylanilides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Closantel	Closantel	Bovine	1 000  μg/kg	Muscle
			3 000  μg/kg	Fat
			1 000  μg/kg	Liver
			3 000  μg/kg	Kidney
		Ovine	1 500  μg/kg	Muscle
			2 000  μg/kg	Fat
			1 500  μg/kg	Liver
			5 000  μg/kg	Kidney
[F28 Rafoxanide	Rafoxanide	Bovine	30 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			30 μg/kg	Fat
			10 μg/kg	Liver
			40 μg/kg	Kidney
		Ovine	100 μg/kg	Muscle
			250 μg/kg	Fat
			150 μg/kg	Liver
			150 μg/kg	Kidney]

2.1.2. Tatra-hydro-imidazoles (imidazolthiazoles) U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Levamisole	Levamisole	Bovine, ovine, porcine, poultry	10 μg/kg	Muscle
			10 μg/kg	Fat
			100 μg/kg	Liver
			10 μg/kg	Kidney

2.1.3. Benzimidazoles and pro-benzimidazoles U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F30 Albendazole	Sum of albendazole sulphoxide, albendazole sulphone, and albendazole 2-amino sulphone, expressed as albendazole	All ruminants	100  μg/kg	Muscle
			100  μg/kg	Fat
			1 000  μg/kg	Liver
			500  μg/kg	Kidney
			100  μg/kg	Milk]
[F31 Albendazole oxide	Sum of albendazole oxide, albendazole sulphone and albendazole 2-aminosulphone, expressed as albendazole	Bovine, ovine	100 μg/kg	Muscle
			100 μg/kg	Fat
			1 000  μg/kg	Liver
			500 μg/kg	Kidney
			100 μg/kg	Milk	]
[F30 Febantel	Sum of extractable residues which may be oxidised to oxfendazole sulphone	All ruminants	50  μg/kg	Muscle
			50  μg/kg	Fat
			500  μg/kg	Liver
			50  μg/kg	Kidney
			10  μg/kg	Milk
Fenbendazole	Sum of extractable residues which may be oxidised to oxfendazole sulphone	All ruminants	50  μg/kg	Muscle
			50  μg/kg	Fat
			500  μg/kg	Liver
			50  μg/kg	Kidney
			10  μg/kg	Milk]
Flubendazole	Sum of flubendazole and (2-amino 1H-benzimidazol-5-yl) (4fluorophenyl) methanone	Porcine, chicken, game birds	50 μg/kg	Muscle
			50 μg/kg	Skin and fat
			400 μg/kg	Liver
			300 μg/kg	Kidney
[F32		Turkey	50 μg/kg	Muscle
			50 μg/kg	Skin and fat
			400 μg/kg	Liver
			300 μg/kg	Kidney	]
	Flubendazole	Chicken	400 μg/kg	Eggs
[F33 Mebendazole	Sum of mebendazole methyl (5-(1-hydroxy, 1-phenyl) methyl-1H-benzimidazol-2-yl) carbamate and (2-amino-1H-benzimidazol-5-yl) phenylmethanone, expressed as mebendazole equivalents	Ovine, caprine, equidae	60 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			60 μg/kg	Fat
			400 μg/kg	Liver
			60 μg/kg	Kidney]
[F15 Netobimin	Sum of albendazole oxide, albendazole sulphone and albendazole 2-aminosulphone, expressed as albendazole	[X5 Bovine, ovine]	100 μg/kg	Muscle	For oral use only
			100 μg/kg	Fat
			1 000  μg/kg	Liver
			500 μg/kg	Kidney
			100 μg/kg	Milk]
[F30 Oxfendazole	Sum of extractable residues which may be oxidised to oxfendazole sulphone	All ruminants	50  μg/kg	Muscle
			50  μg/kg	Fat
			500  μg/kg	Liver
			50  μg/kg	Kidney
			10  μg/kg	Milk]
Oxibendazole	Oxibendazole	Porcine	100 μg/kg	Muscle
			500 μg/kg	Skin and fat
			200 μg/kg	Liver
			100 μg/kg	Kidney
[F30 Thiabendazole	Sum of thiabendazole and 5-hydroxythiabendazole	Caprine	100  μg/kg	Muscle
			100  μg/kg	Fat
			100  μg/kg	Liver
			100  μg/kg	Kidney
			100  μg/kg	Milk]
Triclabendazole	Sum of extractable residues that may be oxidised to ketotriclabendazole	Bovine, ovine	100 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			100 μg/kg	Liver
			100 μg/kg	Kidney

Editorial Information

X5 Substituted by Corrigendum to Commission Regulation (EC) No 807/2001 of 25 April 2001 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Official Journal of the European Communities L 118 of 27 April 2001).

Textual Amendments

F30 Substituted by Commission Regulation (EC) No 1646/2004 of 20 September 2004 amending Annex I to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F31 Inserted by Commission Regulation (EC) No 2393/1999 of 11 November 1999 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F32 Inserted by Commission Regulation (EC) No 2385/1999 of 10 November 1999 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F33 Inserted by Commission Regulation (EC) No 1680/2001 of 22 August 2001 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F34 2.1.4. Phenol derivatives including salicylanides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Nitroxinil	Nitroxinil	Bovine, ovine	400 μg/kg	Muscle
			200 μg/kg	Fat
			20 μg/kg	Liver
			400 μg/kg	Kidney
[F30 Oxyclozanide	Oxyclozanide	All ruminants	20  μg/kg	Muscle
			20  μg/kg	Fat
			500  μg/kg	Liver
			100  μg/kg	Kidney
			10  μg/kg	Milk] ]

Textual Amendments

F34 Inserted by Commission Regulation (EC) No 997/1999 of 11 May 1999 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F35 2.1.5. Benzenesulphonamides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Clorsulon	Clorsulon	Bovine	35 μg/kg	Muscle
			100 μg/kg	Liver
			200 μg/kg	Kidney	]

Textual Amendments

F35 Inserted by Commission Regulation (EC) No 1942/1999 of 10 September 1999 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F27 2.1.6. Piperazine derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Piperazine	Piperazine	Porcine	400 μg/kg	Muscle
			800 μg/kg	Skind and fat
			2 000  μg/kg	Liver
			1 000  μg/kg	Kidney
		Chicken	2 000  μg/kg	Eggs	]

[F36 2.1.7. Tetrahydropyrimides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Morantel	Sum of residues which may be hydrolysed to N-methyl-1,3- propanediamine and expressed as morantel equivalents	Bovine, ovine	100 μg/kg	Muscle
			100 μg/kg	Fat
			800 μg/kg	Liver
			200 μg/kg	Kidney
			50 μg/kg	Milk	]

Textual Amendments

F36 Inserted by Commission Regulation (EC) No 1851/2004 of 25 October 2004 amending Annex I to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits for veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

2.2. Agents acting against ectoparasites U.K.

2.2.1. Organophosphates U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F28 Coumafos	Coumafos	Bees	100 μg/kg	Honey	]
Diazinon	Diazinon	Bovine, ovine, caprine	20 μg/kg	Milk
		Bovine, porcine, ovine, caprine	20 μg/kg	Muscle
			700 μg/kg	Fat
			20 μg/kg	Liver
			20 μg/kg	Kidney
[F15 Phoxim	Phoxim	Ovine	50 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			400 μg/kg	Fat
			50 μg/kg	Kidney
		Porcine	20 μg/kg	Muscle
			700 μg/kg	Skin and fat
			20 μg/kg	Liver
			20 μg/kg	Kidney]

2.2.2. Formamidines U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Amitraz	Sum of amitraz and all metabolites containing the 2,4-DMA moiety, expressed as amitraz	Bovine	200 μg/kg	Fat
			200 μg/kg	Liver
			200 μg/kg	Kidney
			10 μg/kg	Milk
		Ovine	400 μg/kg	Fat
			100 μg/kg	Liver
			200 μg/kg	Kidney
			10 μg/kg	Milk
		Porcine	400 μg/kg	Skin and fat
			200 μg/kg	Liver
			200 μg/kg	Kidney
[F31		Bees (honey)	200 μg/kg	Honey	]
[F37		Caprine	200  μg/kg	Fat
			100  μg/kg	Liver
			200  μg/kg	Kidney
			10  μg/kg	Milk	]

Textual Amendments

F37 Inserted by Commission Regulation (EC) No 1646/2004 of 20 September 2004 amending Annex I to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

2.2.3. Pyrethroids U.K.

a [F13 Further provisions in Commission Directive 98/82/EC are to be observed ( OJ L 290, 29.10.1998, p. 25 ).]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F15 [X5 Cyhalothrin	Cyhalothrin (sum of isomers)	Bovine	500 μg/kg	Fat	Further provisions in Council Directive 94/29/EC are to be observed
			50 μg/kg	Kidney
			50 μg/kg	Milk
Cyfluthrin	Cyfluthrin (sum of isomers)	Bovine	10 μg/kg	Muscle
			50 μg/kg	Fat
			10 μg/kg	Liver
			10 μg/kg	Kidney
			20 μg/kg	Milk] ]
[F38 [F30 Deltamethrin	Deltamethrin	All ruminants	10  μg/kg	Muscle
			50  μg/kg	Fat
			10  μg/kg	Liver
			10  μg/kg	Kidney
			20  μg/kg	Milk]
		[F11 Fin fish	10 μg/kg	Muscle and skin in natural proportions] ]
Flumethrin	Flumethrin (sum of trans-Z isomers)	Bovine	10 μg/kg	Muscle
			150 μg/kg	Fat
			20 μg/kg	Liver
			10 μg/kg	Kidney
			30 μg/kg	Milk
[F39		Ovine	10 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			150 μg/kg	Fat
			20 μg/kg	Liver
			10 μg/kg	Kidney	]
[F13 Permethrin	Permethrin (sum of isomers)	Bovine	50 μg/kg	Muscle
			500 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			50 μg/kg	Milk a	]
[F40 Cypermethrin	Cypermethrin (sum of isomers)	Salmonidae	50 μg/kg	Muscle and skin in natural proportions	]
		[F30 All ruminants	20  μg/kg	Muscle
			200  μg/kg	Fat
			20  μg/kg	Liver
			20  μg/kg	Kidney
			20  μg/kg	Milk a	]
[F41 Alphacypermethrin	Cypermethrin (sum of isomers)	Bovine, ovine	20 μg/kg	Muscle
			200 μg/kg	Fat
			20 μg/kg	Liver
			20 μg/kg	Kidney
			20 μg/kg	Milk] a

Textual Amendments

F38 Inserted by Commission Regulation (EC) No 1815/2001 of 14 September 2001 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F39 Inserted by Commission Regulation (EC) No 2391/2000 of 27 October 2000 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F40 Inserted by Commission Regulation (EC) No 1029/2003 of 16 June 2003 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F41 Inserted by Commission Regulation (EC) No 2011/2003 of 14 November 2003 amending Annexes I and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F16 2.2.4. Acyl urea derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F24 Diflubenzuron	Diflubenzuron	Salmonidae	1 000  μg/kg	Muscle and skin in natural proportions	]
Teflubenzuron	Teflubenzuron	Salmonidae	500 μg/kg	Muscle and skin in natural proportions	]

[F42 2.2.5. Pyrimidines derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Dicyclanil	Sum of dicyclanil and 2, 4, 6-triamino-pyrimidine-5-carbonitrile	Ovine	200 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			[F43 150 μg/kg]	Fat
			400 μg/kg	Liver
			400 μg/kg	Kidney]

Textual Amendments

F43 Substituted by Commission Regulation (EC) No 2391/2000 of 27 October 2000 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

Textual Amendments

F42 Inserted by Commission Regulation (EC) No 1960/2000 of 15 September 2000 amending Annexes I and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F28 2.2.6. Triazine derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Cyromazine	Cyromazine	Ovine	300 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			300 μg/kg	Fat
			300 μg/kg	Liver
			300 μg/kg	Kidney]

2.3. Agents acting against endo- and ectoparasites U.K.

2.3.1. Avermectins U.K.

Phramacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Abamectin	Avermectin B1a	Bovine	10 μg/kg	Fat
			20 μg/kg	Liver
[F27		Ovine	20 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			50 μg/kg	Fat
			25 μg/kg	Liver
			20 μg/kg	Kidney	]
Doramectin	Doramectin	Bovine	10 μg/kg	Muscle	Not for use in bovine from which milk is produced for human consumption
			150 μg/kg	Fat
			100 μg/kg	Liver
			30 μg/kg	Kidney
		Porcine, ovine	20 μg/kg	Muscle	Not for use in ovine from which milk is produced for human consumption
			100 μg/kg	Fat
			50 μg/kg	Liver
			30 μg/kg	Kidney
[F28		Deer, including reindeer	20 μg/kg	Muscle
			100 μg/kg	Fat
			50 μg/kg	Liver
			30 μg/kg	Kidney	]
[F44 Emamectin	Emamectin B1a	Fin fish	100 μg/kg	Muscle and skin in natural proportions	]
Eprinomectin	Eprinomectin B1a	Bovine	[F45 50 μg/kg]	Muscle
			[F45 250 μg/kg]	Fat
			[F45 1 500  μg/kg]	Liver
			[F45 300 μg/kg]	Kidney
			[F45 20 μg/kg]	Milk
Ivermectin	22, 23-Dihydro-avermectin B1a	Bovine	40 μg/kg	Fat
			100 μg/kg	Liver
		Porcine, ovine, equidae	20 μg/kg	Fat
			15 μg/kg	Liver
		Deer, including reindeer	20 μg/kg	Muscle
			100 μg/kg	Fat
			50 μg/kg	Liver
			20 μg/kg	Kidney
Moxidectin	Moxidectin	Bovine, ovine	50 μg/kg	Muscle
			500 μg/kg	Fat
			100 μg/kg	Liver
			50 μg/kg	Kidney
[F14		Bovine	40 μg/kg	Milk	]
[F35		Equidae	50 μg/kg	Muscle
			500 μg/kg	Fat
			100 μg/kg	Liver
			50 μg/kg	Kidney	]

Textual Amendments

F44 Substituted by Commission Regulation (EC) No 1490/2003 of 25 August 2003 amending Annex I to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F45 Substituted by Commission Regulation (EC) No 1943/1999 of 10 September 1999 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

2.4. Agents acting against protozoa U.K.

2.4.1. Triazinetrione derivative U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Toltrazuril	Toltrazuril sulfone	Chicken	100 μg/kg	Muscle	Not for use in animals from which eggs are produced for human consumption
			200 μg/kg	Skin and fat
			600 μg/kg	Liver
			400 μg/kg	Kidney
		Turkey	100 μg/kg	Muscle
			200 μg/kg	Skin and fat
			600 μg/kg	Liver
			400 μg/kg	Kidney
[F46		Porcine	100 μg/kg	Muscle
			150 μg/kg	Skin and fat
			500 μg/kg	Liver
			250 μg/kg	Kidney	]

Textual Amendments

F46 Inserted by Commission Regulation (EC) No 2908/2000 of 29 December 2000 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F46 2.4.2. Quinazolone derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Halofuginone	Halofuginone	Bovine	10 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			25 μg/kg	Fat
			30 μg/kg	Liver
			30 μg/kg	Kidney]

[F11 2.4.3. Carbanilides U.K.

a [F17 Not for use in ovine from which milk is produced for human consumption.] ]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Imidocarb	Imidocarb	Bovine	300 μg/kg	Muscle
			50 μg/kg	Fat
			2 000  μg/kg	Liver
			1 500  μg/kg	Kidney
			50 μg/kg	Milk
		[F17 Ovine a	300 μg/kg	Muscle
			50 μg/kg	Fat
			2 000  μg/kg	Liver
			1 500  μg/kg	Kidney	]

3. Agents acting on the nervous system U.K.

3.1. Agents acting on the central nervous system U.K.

3.1.1. Butyrophenone tranquillisers U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Azaperone	Sum of azaperone and azaperol	Porcine	100 μg/kg	Muscle
			100 μg/kg	Skin and fat
			100 μg/kg	Liver
			100 μg/kg	Kidney

3.2. Agents acting on the autonomic nervous system U.K.

3.2.1. Anti-adrenergics U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Carazolol	Carazolol	Porcine	5 μg/kg	Muscle
			5 μg/kg	Skin and fat
			25 μg/kg	Liver
			25 μg/kg	Kidney
[F9		Bovine	5 μg/kg	Muscle
			5 μg/kg	Fat
			15 μg/kg	Liver
			15 μg/kg	Kidney
			1 μg/kg	Milk	]

[F39 3.2.2. β2 sympathomimetic agents U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Clenbuterol hydrochloride	Clenbuterol	Bovine	0,1 μg/kg	Muscle
			0,5 μg/kg	Liver
			0,5 μg/kg	Kidney
			0,05 μg/kg	Milk
		Equidae	0,1 μg/kg	Muscle
			0,5 μg/kg	Liver
			0,5 μg/kg	Kidney	]

4. Anti-inflammatory agents U.K.

4.1. Nonsteroidal anti-inflammatory agents U.K.

4.1.1. Arylpropionic acid derivative U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F16 Carprofen	Carprofen	Bovine Not for use in animals from which milk is produced for human consumption	500 μg/kg	Muscle
			1 000  μg/kg	Fat
			1 000  μg/kg	Liver
			1 000  μg/kg	Kidney
		Equidae	500 μg/kg	Muscle
			1 000  μg/kg	Fat
			1 000  μg/kg	Liver
			1 000  μg/kg	Kidney	]
Vedaprofen	Vedaprofen	Equidae	50 μg/kg	Muscle
			20 μg/kg	Fat
			100 μg/kg	Liver
			1 000  μg/kg	Kidney

4.1.2. Fenamate group derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F12 Flunixin	Flunixin	Bovine	20 μg/kg	Muscle
			30 μg/kg	Fat
			300 μg/kg	Liver
			100 μg/kg	Kidney
	5-Hydroxyflunixin		40 μg/kg	Milk
	Flunixin	Porcine	50 μg/kg	Muscle
			10 μg/kg	Skin and fat
			200 μg/kg	Liver
			30 μg/kg	Kidney
		[F46 Equidae	10 μg/kg	Muscle
			20 μg/kg	Fat
			100 μg/kg	Liver
			200 μg/kg	Kidney	] ]
Tolfenamic acid	Tolfenamic acid	Bovine	50 μg/kg	Muscle
			400 μg/kg	Liver
			100 μg/kg	Kidney
			50 μg/kg	Milk
		Porcine	50 μg/kg	Muscle
			400 μg/kg	Liver
			100 μg/kg	Kidney

[F26 4.1.3. Enolic acid derivates U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Meloxicam	Meloxicam	Equidae	20 μg/kg	Muscle
			65 μg/kg	Liver
			65 μg/kg	Kidney	]

[F31 4.1.4. Oxican derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Meloxicam	Meloxicam	Bovine	[F47 20 μg/kg]	Muscle
			[F47 65 μg/kg]	Liver
			[F47 65 μg/kg]	Kidney
			[F12 15 μg/kg]	[F12 Milk]
		[F48 Porcine	20 μg/kg	Muscle
			65 μg/kg	Liver
			65 μg/kg	Kidney	] ]

Textual Amendments

F47 Substituted by Commission Regulation (EC) No 2728/1999 of 20 December 1999 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F48 Inserted by Commission Regulation (EC) No 1274/2001 of 27 June 2001 amending Annex I to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F41 4.1.5. Pyrazolone derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Metamizole	4-Methylaminoantipyrin	Bovine	100 μg/kg	Muscle
			100 μg/kg	Fat
			100 μg/kg	Liver
			100 μg/kg	Kidney
			50 μg/kg	Milk
		Porcine	100 μg/kg	Muscle
			100 μg/kg	Skin and fat
			100 μg/kg	Liver
			100 μg/kg	Kidney
		Equidae	100 μg/kg	Muscle
			100 μg/kg	Fat
			100 μg/kg	Liver
			100 μg/kg	Kidney	]

[F25 4.1.6. Phenyl acetic acid derivatives U.K.

a Not for use in animals from which milk is produced for human consumption.]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Diclofenac	Diclofenac	Bovine a	5 μg/kg	Muscle
			1 μg/kg	Fat
			5 μg/kg	Liver
			10 μg/kg	Kidney
		Porcine	5 μg/kg	Muscle
			1 μg/kg	Skin + fat
			5 μg/kg	Liver
			10 μg/kg	Kidney

5. Corticoides U.K.

5.1. Glucocorticoides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F24 Betamethasone	Betamethasone	Bovine	0,75 μg/kg	Muscle
			2,0 μg/kg	Liver
			0,75 μg/kg	Kidney
			0,3 μg/kg	Milk
		Porcine	0,75 μg/kg	Muscle
			2,0 μg/kg	Liver
			0,75 μg/kg	Kidney	]
Dexamethasone	Dexamethasone	Bovine	0,3 μg/kg	Milk
		Bovine, porcine, equidae	0,75 μg/kg	Muscle
			2 μg/kg	Liver
			0,75 μg/kg	Kidney
[F37		Caprine	0,75  μg/kg	Muscle
			2  μg/kg	Liver
			0,75  μg/kg	Kidney
			0,3  μg/kg	Milk]
[F23 Methylprednisolone	Methylprednisolone	Bovine	10 μg/kg	Muscle	Not for use in animals from which milk is produced for human consumption
			10 μg/kg	Fat
			10 μg/kg	Liver
			10 μg/kg	Kidney]
[F49 Prednisolone	Prednisolone	Bovine	4 μg/kg	Muscle
			4 μg/kg	Fat
			10 μg/kg	Liver
			10 μg/kg	Kidney
			6 μg/kg	Milk	]

Textual Amendments

F49 Inserted by Commission Regulation (EC) No 2535/2000 of 17 November 2000 amending Annex I of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F50 6. Agents acting on the reproductive system U.K.

6.1. Progestogens U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Chlormadinone	Chlormadinone	Bovine	4 μg/kg	Fat	For zootechnical use only
			2 μg/kg	Liver
			2,5 μg/kg	Milk
Flugestone acetate	Flugetone acetate	Ovine	1 μg/kg	Milk	For intravaginal use for zootechnical purposes only
		[F21 Caprine	1 μg/kg	Milk	For intra-vaginal use for zootechnical purposes only] ] ]

Textual Amendments

F50 Inserted by Council Regulation (EC) No 2584/2001 of19 December 2001 amending Annexes I and III of Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F4 ANNEX II U.K. LIST OF SUBSTANCES NOT SUBJECT TO MAXIMUM RESIDUE LIMITS

1. Inorganic chemicals U.K.

Pharmacologically active substance(s)	Animal species	Other provisions
Aluminium distearate	All food-producing species
Aluminium hydroxide acetate	All food-producing species
Aluminium phosphate	All food-producing species
[F51 Aluminium salicylate, basic	Bovine	For oral use only; Not for use in animals from which milk is produced for human consumption]
Aluminium tristearate	All food-producing species
Ammonium chloride	All food-producing species
[F9 Barium selenate	Bovine, ovine	]
Bismuth subcarbonate	All food-producing species	For oral use only
Bismuth subgallate	All food-producing species	For oral use only
Bismuth subnitrate	All food-producing species	For oral use only
Bismuth subsalicylate	All food-producing species	For oral use only
Boric acid and borates	All food-producing species
[F16 Bromide, potassium salt	All food producing species	]
Bromide, sodium salt	All mammalian food-producing species	For topical use only
Calcium acetate Calcium benzoate Calcium carbonate Calcium chloride Calcium gluconate Calcium hydroxide Calcium hypophosphite Calcium malate Calcium oxide Calcium phosphate Calcium polyphosphates Calcium propionate Calcium silicate Calcium stearate Calcium sulphate	All food-producing species
Calcium glucoheptonate	All food-producing species
Calcium glucono glucoheptonate	All food-producing species
Calcium gluconolactate	All food-producing species
Calcium glutamate	All food-producing species
[F46 Calcium glycerophosphate	All food producing species	]
Cobalt carbonate	All food-producing species
Cobalt dichloride	All food-producing species
Cobalt gluconate	All food-producing species
Cobalt oxide	All food-producing species
Cobalt sulphate	All food-producing species
Cobalt trioxide	All food-producing species
Copper chloride	All food-producing species
Copper gluconate	All food-producing species
Copper heptanoate	All food-producing species
Copper methionate	All food-producing species
Copper oxide	All food-producing species
Copper sulphate	All food-producing species
Dicopper oxide	All food-producing species
Hydrochloric acid	All food-producing species	For use as excipient
Hydrogen peroxide	All food-producing species
Iodine and iodine inorganic compounds including: Sodium and potassium-iodide Sodium and potassium-iodate Iodophors including polyvinylpyrrolidone-iodine	All food-producing species
Iron dichloride	All food-producing species
Iron sulphate	All food-producing species
Magnesium Magnesium sulphate Magnesium hydroxide Magnesium stearate Magnesium glutamate Magnesium orotate Magnesium aluminium silicate Magnesium oxide Magnesium carbonate Magnesium phosphate Magnesium glycerophosphate Magnesium aspartate Magnesium citrate Magnesium acetate Magnesium trisilicate	All food-producing species
Nickel gluconate	All food-producing species
Nickel sulphate	All food-producing species
Potassium DL-aspartate	All food-producing species
Potassium glucuronate	All food-producing species
Potassium glycerophosphate	All food-producing species
Potassium nitrate	All food-producing species
Potassium selenate	All food-producing species
Sodium chlorite	Bovine	For topical use only
Sodium dichloroisocyanurate	Bovine, ovine, caprine	For topical use only
[F34 Sodium glycerophosphate	All food producing species	]
Sodium hypophosphite	All food-producing species
[F20 Sodium propionate	All food producing species	]
Sodium selenate	All food-producing species
Sodium selenite	All food-producing species
Sulphur	[F52 All food producing species]
Zinc acetate Zinc chloride Zinc gluconate Zinc oleate Zinc stearate	All food-producing species

Textual Amendments

F51 Inserted by Commission Regulation (EC) No 1937/2002 of 30 October 2002 amending Annexes II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F52 Substituted by Commission Regulation (EC) No 544/2003 of 27 March 2003 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

2. Organic compounds U.K.

a [F53 Only for intravaginal therapeutic or zootechnical use and in accordance with the provisions of Directive 96/22/EC.
b [F22 For oral use only.]
c [F54 For oral use; not for use in animals from which milk is produced for human consumption.] ]
Pharmacologically active substance(s)	Animal species	Other provisions
17β-Oestradiol	All mammalian food-producing species	For therapeutic and zootechnical uses only
2-Aminoethanol	All food-producing species
2-Aminoethyl dihydrogenphosphate	All food-producing species
2-Pyrrolidone	All food-producing species	At parenteral doses up to 40 mg/kg bw
8-Hydroxyquinoline	All mammalian food-producing species	For topical use in newborn animals only
Acetyl cysteine	All food-producing species
Alfacalcidol	Bovine	For parturient cows only
Alfaprostol	Rabbits Bovine, porcine, equidae
Bacitracin	Bovine	For intramammary use in lactating cows only and for all tissues except milk
Benzalkonium chloride	All food-producing species	For use as an excipient at concentrations up to 0,05 % only
Benzocaine	All food-producing species	For use as local anaesthetic only
Benzylalcohol	All food-producing species	For use as excipient
Betaine	All food-producing species
Bronopol	Salmonidae	For use only on farmed fertilised eggs
Brotizolam	Bovine	For therapeutic uses only
Buserelin	All food-producing species
Butorphanol tartrate	Equidae	For intravenous administration only
Butyl 4-hydroxybenzoate	All food-producing species
Butylscopolaminium bromide	All food-producing species
Caffeine	All food-producing species
Carbetocin	All mammalian food-producing species
Cefazolin	Bovine Ovine, caprine	For intramammary use, except if the udder may be used as food for human consumption
Cetostearyl alcohol	All food-producing species
Cetrimide	All food-producing species
Chlorhexidine	All food-producing species	For topical use only
Chlorocresol	All food-producing species
Clazuril	Pigeon
Cloprostenol	Bovine, porcine, equidae
Coco alkyl dimethyl betaines	All food-producing species	For use as excipient
Corticotropin	All food-producing species
D-Phe 6 -luteinising-hormone releasing hormone	All food-producing species
Dembrexine	Equidae
Denaverine hydrochloride	Bovine
Detomidine	Bovine, equidae	For therapeutic uses only
[F55 Diclazuril	All ruminants b Porcine b	]
Diethyl phtalate	All food-producing species
Diethylene glycol monoethyl ether	Bovine, porcine
Dimanganese trioxide	All food-producing species	For oral use only
Dimethyl phtalate	All food-producing species
Dinoprost	All mammalian food-producing species
Dinoprost tromethamine	All mammalian food-producing species
Diprophylline	All food-producing species
Etamiphylline camsylate	All food-producing species
Ethanol	All food-producing species	For use as excipient
Ethyl lactate	All food-producing species
Etiproston tromethamine	Bovine, porcine
Fertirelin acetate	Bovine
Flumethrin	Bees (honey)
Folic acid	All food-producing species
Glycerol formal	All food-producing species
Gonadotrophin releasing hormone	All food-producing species
Heptaminol	All food-producing species
Hesperidin	Equidae
Hesperidin methyl chalcone	Equidae
Hexetidine	Equidae	For topical use only
Human chorion gonadotrophin	All food-producing species
Human menopausal urinary gonadotrophin	Bovine
Hydrocortisone	All food-producing species	For topical use only
Iodine organic compounds Iodoform	All food-producing species
Isobutane	All food-producing species
Isoflurane	Equidae	For use as anaesthetic only
Isoxsuprine	Bovine, equidae	For therapeutic use only in accordance with Council Directive 96/22/EEC ( OJ L 125, 23.5.1996, p. 3 )
Ketamine	All food-producing species
Ketanserin tartrate	Equidae
Ketoprofen	Bovine, porcine, equidae
L-tartaric acid and its mono- and di-basic salt of sodium, potassium and calcium	All food-producing species	For use as excipient
Lactic acid	All food-producing species
Lecirelin	Bovine, equidae, rabbits
Lobeline	All food-producing species
Luprostiol	All mammalian species
Malic acid	All food-producing species	For use as excipient
Manganese carbonate	All food-producing species	For oral use only
Manganese chloride	All food-producing species	For oral use only
Manganese gluconate	All food-producing species	For oral use only
Manganese glycerophosphate	All food-producing species	For oral use only
Manganese oxide	All food-producing species	For oral use only
Manganese pidolate	All food-producing species	For oral use only
Manganese ribonucleate	All food-producing species	For oral use only
Manganese sulphate	All food-producing species	For oral use only
Mecillinam	Bovine	For intrauterine use only
Medroxyprogesterone acetate	Ovine	For intravaginal use for zootechnical purposes only
Melatonin	Ovine, caprine
Menadione	All food-producing species
Menbutone	Bovine, ovine, caprine, porcine, equidae
Menthol	All food-producing species
Methyl nicotinate	Bovine, equidae	For topical use only
Mineral hydrocarbons, low to high viscosity including microcristalline waxes, approximately C10-C60; aliphatic, branched aliphatic and alicyclic compounds	All food-producing species	Excludes aromatic and unsaturated compounds
N-butane	All food-producing species
N-butanol	All food-producing species	For use as excipient
Natamycin	Bovine, equidae	For topical use only
Neostigmine	All food-producing species
Nicoboxil	Equidae	For topical use only
Nonivamide	Equidae	For topical use only
Oleyloleate	All food-producing species	For topical use only
Oxytocin	All mammalian food-producing species
Pancreatin	All mammalian food-producing species	For topical use only
Papain	All food-producing species
Papaverine	Bovine	Newborn calves only
Peracetic acid	All food-producing species
Phenol	All food-producing species
Phloroglucinol	All food-producing species
Phytomenadione	All food-producing species
Policresulen	All food-producing species	For topical use only
Polyethylene glycol 15 hydroxystearate	All food-producing species	For use as excipient
Polyethylene glycol 7 glyceryl cocoate	All food-producing species	For topical use only
Polyethylene glycol stearates with 8-40 oxyethylene units	All food-producing species	For use as excipient
Polysulphated glycosaminoglycan	Equidae
Praziquantel	Ovine Equidae	For use in non-lactating sheep only
Pregnant mare serum gonadotrophin	All food-producing species
Prethcamide (crotethamide and cropropamide)	All mammalian food-producing species
Procaine	All food-producing species
Propane	All food-producing species
Propylene glycol	All food-producing species
Quatresin	All food-producing species	For use as preservative only at concentrations of up to 0,5 %
R-Cloprostenol	Bovine, porcine, equidae
Rifaximin	All mammalian food-producing species Bovine	For topical use only For intramammary use, except if the udder may be used as food for human consumption
Romifidine	Equidae	For therapeutic uses only
Sodium 2-methyl-2-phenoxy-propanoate	Bovine, porcine, caprine, equidae
Sodium benzyl 4-hydroxybenzoate	All food-producing species
Sodium butyl 4-hydroxybenzoate	All food-producing species
Sodium cetostearyl sulphate	All food-producing species	For topical use only
Somatosalm	Salmon
Tanninum	All food-producing species
Tau fluvalinate
Terpin hydrate	Bovine, porcine, ovine, caprine
Tetracaine	All food-producing species	For use as anaesthetic only
Theobromine	All food-producing species
Theophylline	All food-producing species
Thiomersal	All food-producing species	For use only as preservatives in multidose vaccines at a concentration not exceeding 0,02 %
Thymol	All food-producing species
Timerfonate	All food-producing species	For use only as preservatives in multidose vaccines at a concentration not exceeding 0,02 %
Trimethylphloroglucinol	All food-producing species
Vitamin D	All food-producing species
Wool alcohols	All food-producing species	For topical use only
[F18 1-Methyl-2-pyrrolidone	Equidae
Cefacetrile	Bovine	For intramammary use only and for all tissues except milk
Enilconazole	Bovine, equidae	For topical use only
Etamsylate	All food producing species
Strychnine	Bovine	For oral use only at dose to 0,1 mg/kg bw]
[F56 Parconazole	Guinea fowl	]
[F34 Biotin	All food producing species
Bromhexine	Bovine Not for use in animals from which milk is produced for human consumption
	Porcine
	Poultry Not for use in animals from which eggs are produced for human consumption
Mercaptamine hydrochloride	All mammalian food-producing species
Praziquantel	Ovine
Pyrantel embonate	Equidae
Vitamin B1	All food-producing species
Vitamin B12	All food-producing species
Vitamin B2	All food-producing species
Vitamin B3	All food-producing species
Vitamin B5	All food-producing species
Vitamin B6	All food-producing species
Vitamin E	All food-producing species	]
[F57 Tiaprost	Bovine, ovine, porcine, equidae	]
[F16 Apramycin	Porcine, rabbits Ovine Not for use in animals from which milk is produced for human consumption Chicken Not for use in animals from which eggs are produced for human consumption	For oral use only
Azamethiphos	Salmonidae
Doxapram	All mammalian food producing species
Piperonyl butoxide	Bovine, ovine, caprine, equidae	For topical use only
Sulfogaiacol	All food producing species
Vetrabutine hydrochloride	Porcine	]
[F35 Fenpipramide hydrochloride	Equidae	For intravenous use only
Hydrochlorothiazide	Bovine
Levomethadone	Equidae	For intravenous use only
Tricaine mesilate	Fin fish	For water borne use only
Trichlormethiazide	All mammalian food producing species	Not for use in animals from which milk is produced for human consumption
Vincamine	Bovine	For use in newborn animals only]
[F58 Atropine	All food producing species
Cefoperazone	Bovine	For intramammary use in lactating cows only and for all tissues except milk]
[F31 2-aminoethanol glucuronate	All food-producing species
Betaine glucuronate	All food-producing species
Bituminosulfonates, ammonium and sodium salts	All mammalian food-producing species	For topical use only Not for use in animals from which milk is produced for human consumption
Chlorphenamine	All mammalian food-producing species
Humic acids and their sodium salts	All food-producing species	For oral use only
Paracetamol	Porcine	For oral use only
Tosylchloramide sodium	Fin fish	For water-borne use only]
[F33	Bovine	For topical use only]
[F24 1-methyl-2-pyrrolidone	All food-producing species
Ergometrine maleate	All mammalian food-producing species	For use in parturient animals only
Jecoris oleum	All food-producing species	For topical use only
Mepivacaine	Equidae	For intra-articular and epidural use as local anaesthetic only
Novobiocin	Bovine	For intrammary use only and for all tissues except milk
Piperazine dihydrochloride	Chicken	For all tissues except eggs
Polyoxyl castor oil with 30 to 40 oxyethylene units	All food-producing species	For use as excipient
Polyoxyl hydrogenated castor oil with 40 to 60 oxyethylene units	All food-producing species	For use as excipient
Xylazine hydrochloride	Bovine, equidae	Not for use in animals from which milk is produced for human consumptiom]
[F12 Butafosfan	Bovine	[F43 For intravenous use only]
Cefalonium	Bovine	For intramammary use and eye treatment only, and for all tissues except milk
Furosemide	Bovine, equidae	For intravenous administration only
Lidocaine	Equidae	For local-regional anaesthesia only]
[F9 3,5-Diiodo-L-thyrosine	All mammalian food-producing species
Levothyroxine	All mammalian food-producing species	]
[F10 Aluminium salicylate, basic	All food producing species except fish For topical use only
Bismuth subnitrate	Bovine	For intramammary use only
Calcium aspartate	All food producing species
Methyl salicylate	All food producing species except fish	For topical use only
Salicylic acid	All food producing species except fish	For topical use only
[F59 Sodium salicylate	Bovine, porcine c	]
Zinc aspartate	All food producing species	]
[F60 Toldimfos	All food producing species	]
[F20 Decoquinate	Bovine, ovine	For oral use only. Not for use in animals from which milk is produced for human consumption
Sodium boroformiate	All food producing species	]
[F61 Thiamylal	All mammalian food producing species	For intravenous administration only
Thiopental sodium	All food-producing species	For intravenous administration only]
[F62 Acetylsalicylic acid	All food producing species except fish	Not for use in animals from which milk or eggs are produced for human consumption
Acetylsalicylic acid DL-lysine	All food producing species except fish	Not for use in animals from which milk or eggs are produced for human consumption
Carbasalate calcium	All food producing species except fish	Not for use in animals from which milk or eggs are produced for human consumption
Sodium acetylsalicylate	All food producing species except fish	Not for use in animals from which milk or eggs are produced for human consumption]
[F15 Linear alkyl benzene sulphonic acids with alkyl chain lengths ranging from C 9 to C 13 , containing less than 2,5 % of chains longer than C 13	Bovine	For topical use only]
[F28 Amprolium	Poultry	For oral use only
Tiludronic acid, disodium salt	Equidae	For intravenous use only]
[F38 Sorbitan trioleate	All food-producing species	]
[F63 Vitamin A	All food producing species	]
[F11 Ammonium lauryl sulphate	All food-producing species
Bronopol	Fin fish
Calcium pantothenate	All food-producing species	]
[F27 Allantoin	All food producing species	For topical use only
Benzocaine	Salmonidae	]
[F64 Dexpanthenol	All food producing species	]
[F26 Azagly-nafarelin	Salmonidae	Not for use in fish from which eggs are produced for human consumption
Deslorelin acetate	Equidae	]
[F65 Hydroxyethylsalicylate	All food producing species except fish	For topical use only
Xylazine hydrochloride	Bovine, equidae	]
[F51 Omeprazole	Equidae	For oral use only]
[F13 Trichlormethiazide	All mammalian food producing species	]
[F53 Progesterone a	Bovine, ovine, caprine, Equidae (female)	]

Textual Amendments

F53 Inserted by Commission Regulation (EC) No 1873/2003 of 24 October 2003 amending Annex II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F54 Inserted by Commission Regulation (EC) No 1875/2004 of 28 October 2004 amending Annexes II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin as regards sodium salicylate and fenvalerate (Text with EEA relevance).

F55 Substituted by Commission Regulation (EC) No 1101/2004 of 10 June 2004 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F56 Inserted by Commission Regulation (EC) No 953/1999 of 5 May 1999 amending Annexes II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F57 Inserted by Commission Regulation (EC) No 998/1999 of 11 May 1999 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F58 Inserted by Commission Regulation (EC) No 1943/1999 of 10 September 1999 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F59 Substituted by Commission Regulation (EC) No 1875/2004 of 28 October 2004 amending Annexes II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin as regards sodium salicylate and fenvalerate (Text with EEA relevance).

F60 Inserted by Commission Regulation (EC) No 1295/2000 of 20 June 2000 amending Annexes II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F61 Inserted by Commission Regulation (EC) No 749/2001 of 18 April 2001 amending Annex II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F62 Substituted by Commission Regulation (EC) No 1029/2003 of 16 June 2003 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F63 Inserted by Commission Regulation (EC) No 1879/2001 of 26 September 2001 amending Annex II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F64 Inserted by Commission Regulation (EC) No 869/2002 of 24 May 2002 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F65 Inserted by Commission Regulation (EC) No 1752/2002 of 1 October 2002 amending Annexes I and II to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

3. Substances generally recognised as safe U.K.

Pharmacologically active substance(s)	Animal species	Other provisions
Absinthium extract	All food-producing species
Acetylmethionine	All food-producing species
Aluminium hydroxide	All food-producing species
Aluminium monostearate	All food-producing species
Ammonium sulfate	All food-producing species
Benzoyl benzoate	All food-producing species
Benzyl p-hydroxybenzoate	All food-producing species
Calcium borogluconate	All food-producing species
Calcium citrate	All food-producing species
Camphor	All food-producing species	External use only
Cardamon extract	All food-producing species
Diethyl sebacate	All food-producing species
Dimethicone	All food-producing species
Dimethyl acetamide	All food-producing species
Dimethyl sulphoxide	All food-producing species
Epinephrine	All food-producing species
Ethyl oleate	All food-producing species
Ethylenediaminetetraacetic acid and salts	All food-producing species
Eucalyptol	All food-producing species
Follicle stimulating hormone (natural FSH from all species and their synthetic analogues)	All food-producing species
Formaldehyde	All food-producing species
Formic acid	All food-producing species
Glutaraldehyde	All food-producing species
Guaiacol	All food-producing species
Heparin and its salts	All food-producing species
Human chorionic gonadotropin (natural HCG and its synthetic analogues)	All food-producing species
Iron ammonium citrate	All food-producing species
Iron dextran	All food-producing species
Iron glucoheptonate	All food-producing species
Isopropanol	All food-producing species
Lanolin	All food-producing species
Luteinising hormone (natural LH from all species and their synthetic analogues)	All food-producing species
Magnesium chloride	All food-producing species
Magnesium gluconate	All food-producing species
Magnesium hypophosphite	All food-producing species
Mannitol	All food-producing species
Methylbenzoate	All food-producing species
Monothioglycerol	All food-producing species
Montanide	All food-producing species
Myglyol	All food-producing species
Orgotein	All food-producing species
Poloxalene	All food-producing species
Poloxamer	All food-producing species
Polyethylene glycols (molecular weight ranging from 200 to 10 000 )	All food-producing species
Polysorbate 80	All food-producing species
Serotonin	All food-producing species
Sodium chloride	All food-producing species
Sodium cromoglycate	All food-producing species
Sodium dioctylsulphosuccinate	All food-producing species
Sodium formaldehydesulphoxylate	All food-producing species
Sodium lauryl sulphate	All food-producing species
Sodium pyrosulphite	All food-producing species
Sodium stearate	All food-producing species
Sodium thiosulphate	All food-producing species
Tragacanth	All food-producing species
Urea	All food-producing species
Zinc oxide	All food-producing species
Zinc sulphate	All food-producing species
[F16 Adenosine and its 5′-mono-, 5′-di- and 5′-triphosphates	All food producing species
Alanine	All food producing species
Arginine	All food producing species
Asparagine	All food producing species
Aspartic acid	All food producing species
Carnitine	All food producing species
Choline	All food producing species
Chymotrypsin	All food producing species
Citrulline	All food producing species
Cysteine	All food producing species
Cytidine and its 5′-mono-, 5′-di- and 5′-triphosphates	All food producing species
Glutamic acid	All food producing species
Glutamine	All food producing species
Glycine	All food producing species
Guanosine and its 5′-mono-, 5′-di- and 5′-triphosphates	All food producing species
Histidine	All food producing species
Hyaluronic acid	All food producing species
Inosine and its 5′-mono-, 5′-di- and 5′-triphosphates	All food producing species
Inositol	All food producing species
Isoleucine	All food producing species
Leucine	All food producing species
Lysine	All food producing species
Methionine	All food producing species
Ornithine	All food producing species
Orotic acid	All food producing species
Pepsin	All food producing species
Phenylalanine	All food producing species
Proline	All food producing species
Serine	All food producing species
Thioctic acid	All food producing species
Threonine	All food producing species
Thymidine	All food producing species
Trypsin	All food producing species
Tryptophan	All food producing species
Tyrosine	All food producing species
Uridine and its 5′-mono-, 5′-di- and 5′-triphosphates	All food producing species
Valine	All food producing species	]

4. Substances used in homeopathic veterinary medicinal products U.K.

Pharmacologically active substance(s)	Animal species	Other provisions
All substances used in homeopathic veterinary medicinal products provided that their concentration in the product does not exceed one part per ten thousand	All food-producing species
[F57 Adonis vernalis	All food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per hundred only
Acqua levici	All food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias only
Atropa belladonna	All food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per hundred only
Convallaria majalis	All food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per thousand only]
[F35 Apocynum cannabinum	All food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per hundred only For oral use only
Harunga madagascariensis	All food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per hundred only
Selenicereus grandiflorus	All food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per hundred only
Thuja occidentalis	All food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per hundred only
Virola sebifera	All food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per thousand only]
[F32 Ruta graveolens	All food-producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per thousand only. Not for use in animals from which milk is produced for human consumption]
[F12 Aesculus hippocastanum	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations in the products not exceeding one part per ten only
Agnus castus	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Ailanthus altissima	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Allium cepa	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Arnicae radix	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding in the products not exceeding one part per ten only
Artemisia abrotanum	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Bellis perennis	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Calendula officinalis	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding in the products not exceeding one part per ten only
Camphora	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations in the products not exceeding one part per hundred only.
Cardiospermum halicacabum	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Crataegus	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Echinacea	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only For topical use only. For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding in the products not exceeding one part per ten only
Eucalyptus globulus	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Euphrasia officinalis	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Ginkgo biloba	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations in the products not exceeding one part per thousand only.
Ginseng	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Hamamelis virginiana	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations in the products not exceeding one part per ten only
Harpagophytum procumbens	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Hypericum perforatum	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Lachnanthes tinctoria	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations in the products not exceeding one part per thousand only.
Lobaria pulmonaria	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Okoubaka aubrevillei	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Prunus laurocerasus	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations in the products not exceeding one part per thousand only.
Serenoa repens	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Silybum marianum	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Solidago virgaurea	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Syzygium cumini	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Turnera diffusa	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only
Viscum album	All-food producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias at concentrations corresponding to the mother tincture and dilutions thereof only]
[F9 Phytolacca americana	All food-producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per thousand only
Urginea maritima	All food-producing species	For use in homeopathic veterinary medicinal products prepared according to homeopathic pharmacopoeias, at concentrations in the products not exceeding one part per hundred only For oral use only]

5. Substances used as food additives in foodstuffs for human consumption U.K.

Pharmacologically active substance(s)	Animal species	Other provisions
Substances with an E number	All food-producing species	Only substances approved as additives in foodstuffs for human consumption, with the exception of preservatives listed in part C of Annex III to European Parliament and Council Directive 95/2/EC ( OJ L 61, 18.3.1995, p. 1 ).

6. Substances of vegetable origin U.K.

Pharmacologically active substance(s)	Animal species	Other provisions
[F66 Aloe vera gel and whole leaf extract of Aloe vera	All food-producing species	For topical use only]
[F12 Aloes, Barbados and Capae, their standardised dry extract and preparations thereof	All food-producing species	]
Angelicae radix aetheroleum	All food-producing species
Anisi aetheroleum	All food-producing species
[F20 Anisi stellati fructus , standardised extracts and preparations thereof	All food producing species	]
[F12 Arnica montana (arnicae flos and arnicae planta tota)	All food-producing species	For topical use only]
Balsamum peruvianum	All food-producing species	For topical use only
[F12 Boldo folium	All food-producing species	]
[F24 Calendulae flos	All food-producing species	For topical use only]
[F32 Capsici fructus acer	All food-producing species	]
[F12 Carlinae radix	All food-producing species	For topical use only]
Carvi aetheroleum	All food-producing species
Caryophylli aetheroleum	All food-producing species
[F18 Centellae asiaticaer extractum	All food producing species	For topical use only]
Chrysanthemi cinerariifolii flos	All food-producing species	For topical use only
[F24 Cimicifugae racemosae rhizoma	All food-producing species	Not for use in animals from which milk is produced for human consumptiom]
[F20 Cinchonae cortex , standardised extracts and preparations thereof	All food producing species	]
Cinnamomi cassiae aetheroleum	All food-producing species
[F20 Cinnamomi cassiae cortex , standardised extracts and preparations thereof	All food producing species	]
Cinnamomi ceylanici aetheroleum	All food-producing species
[F20 Cinnamomi ceylanici cortex , standardised extracts and preparations thereof	All food producing species	]
Citri aetheroleum	All food-producing species
Citronellae aetheroleum	All food-producing species
[F20 Condurango cortex , standardised extracts and preparations thereof	All food producing species	]
Coriandri aetheroleum	All food-producing species
[F12 Cupressi aetheroleum	All food-producing species	For topical use only]
Echinacea purpurea	All food-producing species	For topical use only
Eucalypti aetheroleum	All food-producing species
Foeniculi aetheroleum	All food-producing species
[F20 Frangulae cortex , standardised extracts and preparations thereof	All food producing species
Gentianae radix , standardised extracts and preparations thereof	All food producing species	]
Hamamelis virginiana	All food-producing species	For topical use only
[F32 Hippocastani semen	All food-producing species	For topical use only]
Hyperici oleum	All food-producing species	For topical use only
[F32 Juniperi fructus	All food-producing species
Lauri folii aetheroleum	All food-producing species
Lauri fructus	All food-producing species	]
[F12 Lavandulae aetheroleum	All food-producing species	For topical use only]
Lespedeza capitata	All food-producing species
Lini oleum	All food-producing species
Majoranae herba	All food-producing species
[F10 Matricaria recutita and preparations thereof	All food producing species	]
Matricariae flos	All food-producing species
Medicago sativa extractum	All food-producing species	For topical use only
[F18 Melissae aetheroleum	All food producing species	]
Melissae folium	All food-producing species
[F11 Menthae arvensis aetheroleum	All food-producing species	]
Menthae piperitae aetheroleum	All food-producing species
Millefolii herba	All food-producing species
Myristicae aetheroleum	All food-producing species	For use in newborn animals only
Oxidation products of Terebinthinae oleum	Bovine, porcine, ovine, caprine
Pyrethrum extract	All food-producing species	For topical use only
Quercus cortex	All food-producing species
Quillaia saponins	All food-producing species
[F10 Rhei radix , standardised extracts and preparations thereof	All food producing species	]
Ricini oleum	All food-producing species	For use as excipient
Rosmarini aetheroleum	All food-producing species
Rosmarini folium	All food-producing species
[F32 Ruscus aculeatus	All food-producing species	For topical use only]
Salviae folium	All food-producing species
Sambuci flos	All food-producing species
Sinapis nigrae semen	All food-producing species
[F32 Strychni semen	Bovine, ovine, caprine	For oral use only at doses up to the equivalent of 0,1 mg strychnine/kg bw]
[F12 Symphyti radix	All food-producing species	For topical use on intact skin only]
Terebinthinae aetheroleum rectificatum	All food-producing species	For topical use only
Terebinthinae laricina	All food-producing species	For topical use only
Thymi aetheroleum	All food-producing species
Tiliae flos	All food-producing species
Urticae herba	All food-producing species

Textual Amendments

F66 Inserted by Commission Regulation (EC) No 2758/1999 of 22 December 1999 amending Annex II of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F7 7. Anti-infectious agents U.K.

Pharmacologically active substance(s)	Animal species	Other provisions
Oxalic acid	Honey bees	] ]

[F4 ANNEX III U.K. LIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES USED IN VETERINARY MEDICINAL PRODUCTS FOR WHICH PROVISIONAL MAXIMUM RESIDUE LIMITS HAVE BEEN FIXED

1. Anti-infectious agents U.K.

1.1. Chemotheurapeutics U.K.

1.1.2. Benzenesulphonamides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Clorsulon	Clorsulon	Bovine	50 μg/kg	Muscle	Provisional MRLs expire on 1 January 2000
			150 μg/kg	Liver
			400 μg/kg	Kidney

1.2. Antibiotics U.K.

1.2.1. Beta-lactamase inhibitors U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Clavulanic acid	Clavulanic acid	Bovine, ovine	200 μg/kg	Milk	[F45 Provisional MRLs expire on 1 July 2001]
		Bovine, ovine, porcine	200 μg/kg	Muscle
			200 μg/kg	Fat
			200 μg/kg	Liver
			200 μg/kg	Kidney

1.2.2. Macrolides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F10 Acetylisovaleryltylosin	Sum of acetylisovaleryltylosin and 3-O-acetyltylosin	Porcine	100 μg/kg	Muscle	Provisional MRLs expire on 1.7.2001
			100 μg/kg	Skin and fat
			100 μg/kg	Liver
			100 μg/kg	Kidney]
Erythromycin	MRLs apply to all microbiological active residues expressed as erythromycin equivalent	Bovine, ovine	40 μg/kg	Milk	Provisional MRLs expire on 1 June 2000
		Bovine, ovine, porcine, poultry	400 μg/kg	Muscle
			400 μg/kg	Fat
			400 μg/kg	Liver
			400 μg/kg	Kidney
		Poultry	200 μg/kg	Eggs
Josamycin	Josamycin	Chicken	200 μg/kg	Muscle	[F67 Provisional MRLs expire on 1.7.2002]
			200 μg/kg	Fat
			200 μg/kg	Liver
			400 μg/kg	Kidney
			200 μg/kg	Eggs
[F56	Sum of the microbiologically active metabolites, expressed as josamycin	Porcine	200 μg/kg	Muscle	Provisional MRLs expire on 1.7.2002
			200 μg/kg	Skin and fat
			200 μg/kg	Liver
			400 μg/kg	Kidney]
[F24 Tilmicosin	Tilmicosin	Bovine	40 μg/kg	Milk	Provisional MRLs expire on 1.1.2001]
[F51 Tulathromycin	(2R,3S,4R,5R,8R,10R,11R,12S, 13S,14R)-2- ethyl-3,4,10,13-tetrahydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa- 6-azacyclopent-decan-15-one expressed as tulathromycin equivalents	Bovine	100 μg/kg	Fat	Provisional MRLs expire on 1 July 2004 ; not for use in animals from which milk is produced for human consumption
			3 000  μg/kg	Liver
			3 000  μg/kg	Kidney
		Porcine	100 μg/kg	Skin and fat	Provisional MRLs expire on 1 July 2004
			3 000  μg/kg	Liver
			3 000  μg/kg	Kidney]

Textual Amendments

F67 Substituted by Commission Regulation (EC) No 2338/2000 of 20 October 2000 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F18 1.2.4. Cephalosporins U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Cefacetrile	Cefacetrile	Bovine	125 μg/kg	Milk	[F68 Provisional MRLs expire on 1.1.2002] For intrammamary use only
[F12 Cefalonium	Cefalonium	Bovine	10 μg/kg	Milk	[F69 Provisional MRLs expire on 1.1.2003] ]
[F58 Cefoperazone	Cefoperazone	Bovine	50 μg/kg	Milk	Provisional MRLs expire on 1 January 2001]
[F70 Cefquinome	Cefquinome	Porcine	50 μg/kg	Muscle	Provisional MRLs expire on 1.1.2000
			50 μg/kg	Skin + fat
			100 μg/kg	Liver
			200 μg/kg	Kidney]
Cephapirin	Sum of cephapirin and desacetylcephapirin	Bovine	50 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			50 μg/kg	Fat
			50 μg/kg	Liver
			100 μg/kg	Kidney
			10 μg/kg	Milk]

Textual Amendments

F68 Substituted by Commission Regulation (EC) No 807/2001 of 25 April 2001 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F69 Substituted by Commission Regulation (EC) No 1322/2001 of 29 June 2001 amending Annexes I and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F70 Inserted by Commission Regulation (EC) No 954/1999 of 5 May 1999 amending Annex III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

1.2.5. Aminoglycosides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Aminosidine	Aminosidine	Bovine, porcine, rabbits, chicken	500 μg/kg	Muscle	Provisional MRLs expire on 1 July 2000
			1 500  μg/kg	Liver
			1 500  μg/kg	Kidney
Apramycin	Apramycin	Bovine	1 000  μg/kg	Muscle	Provisional MRLs expire on 1 July 1999
		For use in non-lactating cattle only	1 000  μg/kg	Fat
			10 000  μg/kg	Liver
			20 000  μg/kg	Kidney
		Porcine	1 000  μg/kg	Muscle
			1 000  μg/kg	Skin and fat
			1 000  μg/kg	Liver
			5 000  μg/kg	Kidney
[F71 Dihydrostreptomycin	Dihydrostreptomycin	Bovine, ovine	500 μg/kg	Muscle	Provisional MRLs expire on 1.6.2002
			500 μg/kg	Fat
			500 μg/kg	Liver
			1 000  μg/kg	Kidney
			200 μg/kg	Milk
		Porcine	500 μg/kg	Muscle
			500 μg/kg	Skin and fat
			500 μg/kg	Liver
			1 000  μg/kg	Kidney
Gentamicin	Gentamicin	Bovine	100 μg/kg	Milk	Provisional MRLs expire on 1.6.2002
		Bovine, porcine	50 μg/kg	Muscle
			50 μg/kg	Fat
			200 μg/kg	Liver
			750 μg/kg	Kidney]
[F16 Kanamycin	Kanamycin	Rabbits	100 μg/kg	Muscle	[F72 Provisional MRLs expire on 1.1.2004]
			100 μg/kg	Fat
			600 μg/kg	Liver
			2 500  μg/kg	Kidney
		Bovine, ovine	100 μg/kg	Muscle
			100 μg/kg	Fat
			600 μg/kg	Liver
			2 500  μg/kg	Kidney
			150 μg/kg	Milk
		Porcine, chicken	100 μg/kg	Muscle
			100 μg/kg	Skin + fat
			600 μg/kg	Liver
			2 500  μg/kg	Kidney]
[F71 Neomycin (including framycetin)	Neomycin B	Bovine, porcine, chicken	500 μg/kg	Muscle	Provisional MRLs expire on 1.6.2002
			500 μg/kg	Fat
			500 μg/kg	Liver
			5 000  μg/kg	Kidney
		Bovine	500 μg/kg	Milk
		Chicken	500 μg/kg	Eggs]
Spectinomycin	Spectinomycin	Bovine	200 μg/kg	Milk	Provisional MRLs expire on 1 July 2000
		Bovine, porcine, poultry	300 μg/kg	Muscle
			500 μg/kg	Fat
			2 000  μg/kg	Liver
			5 000  μg/kg	Kidney
[F12		Ovine Not for use in animals from which milk is produced for human consumption	300 μg/kg	Muscle	Provisional MRLs expire on 1.1.2002
			500 μg/kg	Fat
			2 000  μg/kg	Liver
			5 000  μg/kg	Kidney
		Chicken	200 μg/kg	Eggs]
[F71 Streptomycin	Streptomycin	Bovine, ovine	500 μg/kg	Muscle	Provisional MRLs expire on 1.6.2002
			500 μg/kg	Fat
			500 μg/kg	Liver
			1 000  μg/kg	Kidney
			200 μg/kg	Milk
		Porcine	500 μg/kg	Muscle
			500 μg/kg	Skin and fat
			500 μg/kg	Liver
			1 000  μg/kg	Kidney]

Textual Amendments

F71 Substituted by Commission Regulation (EC) No 1960/2000 of 15 September 2000 amending Annexes I and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F72 Substituted by Commission Regulation (EC) No 2162/2001 of 7 November 2001 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

1.2.6. Quinolones U.K.

a [F7 Provisional MRLs expire 1 January 2006 .
b Not for use in animals from which milk is produced for human consumption.]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F56 Danofloxacin	Danofloxacin	Porcine	100 μg/kg	Muscle	Provisional MRLs expire on 1.1.2000
			50 μg/kg	Skin and fat
			200 μg/kg	Liver
			200 μg/kg	Kidney]
Decoquinate	Decoquinate	Bovine, ovine	500 μg/kg	Muscle	Provisional MRLs expire on 1 July 2000
			500 μg/kg	Fat
			500 μg/kg	Liver
			500 μg/kg	Kidney
[F34 Difloxacin	Difloxacin	Bovine Not for use in animals from which milk is produced for human consumption	400 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			100 μg/kg	Fat
			1 400 μg/kg	Liver
			800 μg/kg	Kidney
		Porcine	400 μg/kg	Muscle
			100 μg/kg	Skin and fat
			800 μg/kg	Liver
			800 μg/kg	Kidney]
Enrofloxacin	Sum of enrofloxacin and ciprofloxacin	Ovine	100 μg/kg	Muscle	Provisional MRLs expire on 1 July 1999
			100 μg/kg	Fat
			300 μg/kg	Liver
			200 μg/kg	Kidney
Flumequine	Flumequine	Bovine, ovine, porcine, chicken	50 μg/kg	Muscle	Provisional MRLs expire on 1 January 2000
			50 μg/kg	Fat or skin and fat
			100 μg/kg	Liver
			300 μg/kg	Kidney
		Salmonidae	150 μg/kg	Muscle and skin
Marbofloxacin	Marbofloxacin	Bovine	150 μg/kg	Muscle	Provisional MRLs expire on 1 July 2000
			50 μg/kg	Fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
			75 μg/kg	Milk
		Porcine	150 μg/kg	Muscle
			50 μg/kg	Skin and fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
[F18 [F8 Oxolinic acid a	Oxolinic acid	Bovine b	100 µg/kg	Muscle
			50 µg/kg	Fat
			150 µg/kg	Liver
			150 µg/kg	Kidney]
		Porcine	100 μg/kg	Muscle
			50 μg/kg	Skin + fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
		Chicken	100 μg/kg	Muscle
			50 μg/kg	Skin + fat
			150 μg/kg	Liver
			150 μg/kg	Kidney
			50 μg/kg	Eggs
		Fin fish	300 μg/kg	Muscle and skin in natural proportions]

1.2.9. Polymyxins U.K.

Phamarcologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Colistin	Colistin	Bovine, ovine	50 μg/kg	Milk	[F67 Provisional MRLs expire on 1.7.2002]
		Bovine, ovine, porcine, chicken, rabbits	150 μg/kg	Muscle
			150 μg/kg	Fat
			150 μg/kg	Liver
			200 μg/kg	Kidney
		Chicken	300 μg/kg	Eggs

1.2.10. Penicillins U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F18 Nafcillin	Nafcillin	Bovine	300 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			300 μg/kg	Fat
			300 μg/kg	Liver
			300 μg/kg	Kidney
			30 μg/kg	Milk]
Penethamate	Benzylpenicillin	Ovine	50 μg/kg	Muscle	Provisional MRLs expire on 1 January 2000
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			4 μg/kg	Milk
		Porcine	50 μg/kg	Muscle
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney

1.2.11. Florfenicol and related compounds U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Florfenicol	Sum of florfenicol and its metabolites measured as florfenicol-amine	Fish	1 000  μg/kg	Muscle and skin in natural proportions	Provisional MRLs expire on 1 July 2001
[F18 Thiamphenicol	Thiamphenicol	Ovine	50 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			50 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
		Porcine	50 μg/kg	Muscle
			50 μg/kg	Skin + fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
		Fin fish	50 μg/kg	Muscle and skin in natural proportions]

[F56 1.2.12. Polypeptides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Bacitracin	Bacitracin	Bovine	150 μg/kg	Milk	Provisional MRLs expire on 1.7.2001]

[F18 1.2.13. Lincosamides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Lincomycin	Lincomycin	Ovine	100 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			50 μg/kg	Fat
			500 μg/kg	Liver
			1 500 μg/kg	Kidney
			150 μg/kg	Milk
		Porcine	100 μg/kg	Muscle
			50 μg/kg	Skin + fat
			500 μg/kg	Liver
			1 500 μg/kg	Kidney
		Chicken	100 μg/kg	Muscle
			50 μg/kg	Skin + fat
			500 μg/kg	Liver
			1 500 μg/kg	Kidney
			50 μg/kg	Eggs
[F56 Pirlimycin	Pirlimycin	Bovine	100 μg/kg	Muscle	Provisional MRLs expire on 1.7.2000
			100 μg/kg	Fat
			1 000 μg/kg	Liver
			400 μg/kg	Kidney
			100 μg/kg	Milk] ]

[F12 1.2.14. Pleuromutilines U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Tiamulin	Sum of metabolites that may be hydrolysed to 8-a-hydroxymutilin	Turkey	100 μg/kg	Muscle	Provisional MRLs expire on 1.7.2001
			100 μg/kg	Skin and fat
			300 μg/kg	Liver]

2. Antiparasitic agents U.K.

2.1. Agents acting against endoparasites U.K.

[F34 2.1.1. Phenol derivatives including salicylanides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Oxyclozanide	Oxyclozanide	Bovine	20 μg/kg	Muscle	[F67 Provisional MRLs expire on 1.7.2002]
			20 μg/kg	Fat
			500 μg/kg	Liver
			100 μg/kg	Kidney
			10 μg/kg	Milk
		Ovine	20 μg/kg	Muscle
			20 μg/kg	Fat
			500 μg/kg	Liver
			100 μg/kg	Kidney]

2.1.2. Benzimidazoles and pro-benzimidazoles U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Albendazole sulphoxide	Sum of albendazole, albendazole sulphoxide, albendazole sulphone, and albendazole 2-amino sulphone, expressed as albendazole	Bovine, ovine	100 μg/kg	Milk	Provisional MRLs expire on 1 January 2000
		Bovine, ovine, pheasant	100 μg/kg	Muscle
			100 μg/kg	Fat
			1 000  μg/kg	Liver
			500 μg/kg	Kidney
[F12 Mebendazole	Sum of mebendazole methyl (5-(1-hidroxy, 1-phenyl) methyl-1H-benzimidazol-2-yl) carbamate and (2-amino-1H-benzimidazol-5-yl) phenylmethanone, expressed as mebendazole equivalents	Ovine, caprine, equidae Not for use in animals from which milk is produced for human consumption	60 μg/kg	Muscle	Provisional MRLs expire on 1.1.2002
			60 μg/kg	Fat
			400 μg/kg	Liver
			60 μg/kg	Kidney]
Netobimin	Sum of netobimin and albendazole and metabolites of albendazole measured as 2-amino- benzimidazole sulphone	Bovine, ovine, caprine	100 μg/kg	Muscle	Provisional MRLs expire on 31 July 1999
			100 μg/kg	Fat
			1 000  μg/kg	Liver
			500 μg/kg	Kidney
			100 μg/kg	Milk

[F34 2.1.3. Tetrahydropyrimides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Morantel	Sum of residues which may be hydrolysed to N-Methyl-1,3-propanediamine and expressed as morantel equivalents	Bovine, ovine	100 μg/kg	Muscle	[F69 Provisional MRLs expire on 1.7.2003]
			100 μg/kg	Fat
			800 μg/kg	Liver
			200 μg/kg	Kidney
			100 μg/kg	Milk
		Porcine	100 μg/kg	Muscle
			100 μg/kg	Skin and fat
			800 μg/kg	Liver
			200 μg/kg	Kidney]

[F24 2.1.5. Piperazine derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Piperazine	Piperazine	Porcine	400 μg/kg	Muscle	[F73 Provisional MRLs expire on 1.7.2003]
			800 μg/kg	Skin and fat
			2 000  μg/kg	Liver
			1 000  μg/kg	Kidney
		Chicken	2 000  μg/kg	Eggs]

Textual Amendments

F73 Substituted by Commission Regulation (EC) No 1478/2001 of 18 July 2001 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F12 2.1.6. Salicylanilides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Rafoxanide	Rafoxanide	Bovine Not for use in animals from which milk is produced for human consumption	30 μg/kg	Muscle	Provisional MRLs expire on 1.7.2001
			30 μg/kg	Fat
			10 μg/kg	Liver
			40 μg/kg	Kidney
		Ovine Not for use in animals from which milk is produced for human consumption	100 μg/kg	Muscle
			250 μg/kg	Fat
			150 μg/kg	Liver
			150 μg/kg	Kidney]

2.2. Agents acting against ectoparasites U.K.

2.2.1. Formamidines U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Amitraz	Sum of amitraz and all metabolites containing the 2,4-DMA moeity, expressed as amitraz	Bees	200 μg/kg	Honey	Provisional MRLs expire on 1 July 1999

2.2.2. Iminophenyl thiazolidine derivative U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Cymiazole	Cymiazole	Bees	1 000  μg/kg	Honey	[F74 Provisional MRLs expire on 1.7.2001]

Textual Amendments

F74 Substituted by Commission Regulation (EC) No 1931/1999 of 9 September 1999 amending Annexes I, II and III of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

2.2.3. Pyretrin and pyrethroids U.K.

a [F54 Provisional MRLs expire on 1 July 2006 .]
Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Cyfluthrin	Cyfluthrin	Bovine	10 μg/kg	Muscle	Provisional MRLs expire on 1 January 2001
			50 μg/kg	Fat
			10 μg/kg	Liver
			10 μg/kg	Kidney
			20 μg/kg	Milk
				Further provisions in Council Directive 94/29/EC are to be observed ( OJ L 189, 23.7.1994, p. 67 )
[F70 Alphacypermethrin	Cypermethrin (sum of isomers)	Bovine, ovine	20 μg/kg	Muscle	[F75 Provisional MRLs expire on 1.7.2003 Further provisions in Directive 93/57/EC are to be observed]
			200 μg/kg	Fat
			20 μg/kg	Liver
			20 μg/kg	Kidney
			20 μg/kg	Milk [F76 Further provisions in Council Directive 93/57/EC ( OJ L 211, 23.8.1992, p. 1 ) are to be observed]
		Chicken	50 μg/kg	Muscle
			50 μg/kg	Skin + fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			50 μg/kg	Eggs
[F75 Cypermethrin	Cypermethrin (sum of isomers)	Bovine	20 μg/kg	Muscle	Provisional MRLs expire on 1.7.2003 Further provisions in Directive 93/57/EC are to be observed
			200 μg/kg	Fat
			20 μg/kg	Liver
			20 μg/kg	Kidney
			20 μg/kg	Milk
	Cypermethrin (sum of isomers)	Ovine	20 μg/kg	Muscle	Provisional MRLs expire on 1.7.2003 Not for use in animals from which milk is produced for human consumption
			200 μg/kg	Fat
			20 μg/kg	Liver
			20 μg/kg	Kidney]
		Porcine	20 μg/kg	Muscle
			200 μg/kg	Skin + fat
			20 μg/kg	Liver
			20 μg/kg	Kidney
		Chicken	50 μg/kg	Muscle
			50 μg/kg	Skin + fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			50 μg/kg	Eggs
		Salmonidae	50 μg/kg	Muscle and skin in natural proportions	[F23 Provisional MRLs expire on 1.7.2003] ]
[F35 Deltamethrin	Deltamethrin	Bovine	10 μg/kg	Muscle	Provisional MRLs expire on 1 July 2001
			50 μg/kg	Fat
			10 μg/kg	Liver
			10 μg/kg	Kidney
			20 μg/kg	Milk
		Ovine Not for use in animals from which milk is produced for human consumption	10 μg/kg	Muscle
			50 μg/kg	Fat
			10 μg/kg	Liver
			10 μg/kg	Kidney
		Chicken	10 μg/kg	Muscle	[F38 Provisional MRLs expire on 1.7.2003]
			50 μg/kg	Skin + fat
			10 μg/kg	Liver
			10 μg/kg	Kidney
			50 μg/kg	Eggs
[F42		Fin fish	10 μg/kg	Muscle and skin in natural proportions	Provisional MRLs expire on 1.1.2002] ]
[F59 Fenvalerate a	Fenvalerate (sum of RR, SS, RS and SR isomers)	Bovine	25 μg/kg	Muscle
			250 μg/kg	Fat
			25 μg/kg	Liver
			25 μg/kg	Kidney
			40 μg/kg	Milk]
[F68 Permethrin	Permethrin (sum of isomers)	Chicken, porcine	50 μg/kg	Muscle	Provisional MRLs expire on 1.1.2003
			500 μg/kg	Skin and fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
		Bovine, caprine	50 μg/kg	Muscle	Provisional MRLs expire on 1.1.2003
			500 μg/kg	Fat
			50 μg/kg	Liver
			50 μg/kg	Kidney
			50 μg/kg	Milk	Further provisions in Commission Directive 98/82/EC are to be observed ( OJ L 290, 29.10.1998, p. 25 )
		Chicken	50 μg/kg	Eggs	Provisional MRLs expire on 1.1.2003]

Textual Amendments

F75 Substituted by Commission Regulation (EC) No 869/2002 of 24 May 2002 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F76 Deleted by Commission Regulation (EC) No 869/2002 of 24 May 2002 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

2.2.4. Organophosphates U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Azamethiphos	Azamethiphos	Salmonidae	100 μg/kg	Muscle and skin in natural proportions	Provisional MRLs expire on 1 June 1999
[F16 Coumafos	Coumafos	Bees	100 μg/kg	Honey	Provisional MRLs expire on 1.7.2001]
[F32 Phoxim	Phoxim	Porcine	20 μg/kg	Muscle	Provisional MRLs expire on 1 January 2001
			700 μg/kg	Skin and fat
			20 μg/kg	Liver
			20 μg/kg	Kidney
		[F39 Ovine	50 μg/kg	Muscle	Provisional MRLs expire on 1.7.2001 ; not for use in animals from which milk is produced for human consumption
			400 μg/kg	Fat
			50 μg/kg	Kidney]
		[F41 Chicken	50 μg/kg	Muscle	Provisional MRLs expire on 1.7.2005 .
			550 μg/kg	Skin and fat
			25 μg/kg	Liver
			50 μg/kg	Kidney
			60 μg/kg	Eggs] ]
[F12 Propetamphos	Sum of residues of propetamphos and desisopropyl-propetamphos	Ovine Not for use in animals from which milk is produced for human consumption	90 μg/kg	Fat	Provisional MRLs expire on 1.1.2001
			90 μg/kg	Kidney]

2.2.5. Acyl urea derivates U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Teflubenzuron	Teflubenzuron	Salmonidae	500 μg/kg	Muscle and skin in natural proportions	Provisional MRLs expire on 1 July 1999
[F34 Diflubenzuron	Diflubenzuron	Salmonidae	1 000 μg/kg	Muscle and skin in natural proportions	Provisional MRLs expire on 1.7.2000]

[F31 2.2.6. Pyrimidines derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Dicyclanil	Sum of dicyclanil and 2,4,6-triamino-pyrimidine-5-carbonitrile	Ovine	200 μg/kg	Muscle	Provisional MRLs expire on 1 July 2000 ; Not for use in animals from which milk is produced for human consumption
			50 μg/kg	Fat
			400 μg/kg	Liver
			400 μg/kg	Kidney]

[F24 2.2.7. Triazine derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Cyromazine	Cyromazine	Ovine	300 μg/kg	Muscle	Provisional MRLs expire on 1.7.2001 Not for use in animals from which milk is produced for human consumption
			300 μg/kg	Fat
			300 μg/kg	Liver
			300 μg/kg	Kidney]

2.3. Agents acting against endo- and ectoparasites U.K.

2.3.1. Avermectins U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F12 Abamectin	Avermectin B1a	Ovine	20 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			50 μg/kg	Fat
			25 μg/kg	Liver
			20 μg/kg	Kidney
Doramectin	Doramectin	Deer, inclusing reindeer	20 μg/kg	Muscle	Provisional MRLs expire on 1.7.2001
			100 μg/kg	Fat
			50 μg/kg	Liver
			30 μg/kg	Kidney]
Moxidectin	Moxidectin	Equidae	50 μg/kg	Muscle	Provisional MRLs expire on 1 January 2000
			500 μg/kg	Fat
			100 μg/kg	Liver
			50 μg/kg	Kidney

[F56 2.4. Agents acting against protozoa U.K.

2.4.1. Carbanilides U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Imidocarb	Imidocarb	Bovine, ovine	300 μg/kg	Muscle	Provisonal MRLs expire on 1.1.2002
			50 μg/kg	Fat
			2 000 μg/kg	Liver
			1 500 μg/kg	Kidney
			50 μg/kg	Milk

[F34 2.4.2. Quinazolone derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Halofuginone	Halofuginone	Bovine	10 μg/kg	Muscle	Provisional MRL's expire on 1.1.2001
			25 μg/kg	Fat
			30 μg/kg	Liver
			30 μg/kg	Kidney]

[F24 2.4.3. Triazinetrione derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Toltrazuril	Toltrazuril sulfone	Porcine	100 μg/kg	Muscle	Provisional MRLs expire on 1.1.2001
			150 μg/kg	Skin and fat
			500 μg/kg	Liver
			250 μg/kg	Kidney]

[F60 2.4.4. Other anti-protozoal agents U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRL	Target tissues	Other provisions
Amprolium	Amprolium	Chicken, turkey	200 μg/kg	Muscle	Provisional MRLs expire on 1.1.2002
			200 μg/kg	Skin and fat
			200 μg/kg	Liver
			400 μg/kg	Kidney
			1 000  μg/kg	Eggs] ]

3. Agents acting on the nervous system U.K.

3.2. Agents acting on the autonomic nervous system U.K.

3.2.1. β 2 sympathomimetic agents U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Clenbuterol hydrochloride	Clenbuterol	Bovine	0,1 μg/kg	Muscle	Provisional MRLs expire on 1 July 2000
		Indication: solely for tocolysis in parturient cows	0,5 μg/kg	Liver
			0,5 μg/kg	Kidney
			0,05 μg/kg	Milk
		Equidae	0,1 μg/kg	Muscle
		Indications: tocolysis and the treatment of respiratory ailments	0,5 μg/kg	Liver
			0,5 μg/kg	Kidney

[F56 3.2.2. Anti-adrenergics U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Carazolol	Carazolol	Bovine	5 μg/kg	Muscle	Provisional MRLs expire on 1.1.2000
			5 μg/kg	Fat
			15 μg/kg	Liver
			15 μg/kg	Kidney
			1 μg/kg	Milk]

5. Anti-inflammatory agents U.K.

5.1. Nonsteroidal anti-inflammatory agents U.K.

5.1.1. Arylpropionic acid derivative U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Carprofen	Carprofen	Bovine	500 μg/kg	Muscle	Provisional MRLs expire on 1 January 2000
			500 μg/kg	Fat
			1 000  μg/kg	Liver
			1 000  μg/kg	Kidney
		Equidae	50 μg/kg	Muscle
			100 μg/kg	Fat
			1 000  μg/kg	Liver
			1 000  μg/kg	Kidney

5.1.2. Enolic acid derivates U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Meloxicam	Meloxicam	Bovine	25 μg/kg	Muscle	Provisional MRLs expire on 1 January 2000
			60 μg/kg	Liver
			35 μg/kg	Kidney

[F12 5.1.3. Pyrazolone derivatives U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
[F69 Metamizole	4-Methylaminoantipyrin	Bovine, porcine, equidae	200 μg/kg	Muscle	Provisional MRLs expire on 1.7.2003 . Not for use in animals from which milk is produced for human consumption
			200 μg/kg	Fat
			200 μg/kg	Liver
			200 μg/kg	Kidney] ]

[F50 6. Agents acting on the reproductive system U.K.

6.1. Progestogens U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Altrenogest	Altrenogest	Porcine	3 μg/kg	[F77 Skin and fat]	[F77 Provisional MRLs expire on 1.1.2005 ; for zootechnical use only]
			3 μg/kg	Liver
			3 μg/kg	Kidney
		Equidae	3 μg/kg	Fat
			3 μg/kg	Liver
			3 μg/kg	Kidney
[F78 Flugestone acetate	Flugestone acetate	Ovine, caprine	0,5 μg/kg	Muscle	Provisional MRLs expire on 1.1.2008 ; for therapeutic or zootechnical use only
			0,5 μg/kg	Fat
			0,5 μg/kg	Liver
			0,5 μg/kg	Kidney
Norgestomet	Norgestomet	Bovine	0,5 μg/kg	Muscle	Provisional MRLs expire on 1.1.2008 ; for therapeutic or zootechnical use only
			0,5 μg/kg	Fat
			0,5 μg/kg	Liver
			0,5 μg/kg	Kidney
			0,15 μg/kg	Milk] ]

Textual Amendments

F77 Substituted by Commission Regulation (EC) No 1530/2002 of 27 August 2002 amending Annexes I, II and III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

F78 Substituted by Commission Regulation (EC) No 665/2003 of 11 April 2003 amending Annex III to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (Text with EEA relevance).

[F10 7. Corticoids U.K.

7.1. Glucocorticoids U.K.

Pharmacologically active substance(s)	Marker residue	Animal species	MRLs	Target tissues	Other provisions
Methylprednisolone	Methylprednisolone	Bovine	10 μg/kg	Muscle	Provisional MRLs expire on 1.7.2001 . Not for use in animals from which milk is produced for human consumption
			10 μg/kg	Fat
			10 μg/kg	Liver
			10 μg/kg	Kidney] ]

[F4 ANNEX IV U.K. LIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES FOR WHICH NO MAXIMUM LEVELS CAN BE FIXED

Pharmacologically active substance(s)
Aristolochia spp. and preparations thereof
Chloramphenicol
Chloroform
Chlorpromazine
Colchicine
Dapsone
Dimetridazole
Metronidazole
Nitrofurans (including furazolidone)
Ronidazole]

[F79 ANNEX V U.K. Information and particulars to be included in an application for the establishment of a maximum residue limit for a pharmacologically active substance used in veterinary medicinal products

Textual Amendments

F79 Substituted by Commission Regulation (EEC) No 762/92 of 27 March 1992 modifying Annex V to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

Administrative particulars U.K.

1 Name or corporate name and permanent address of the applicant. U.K.

2 Name of the veterinary medicinal product. U.K.

3 Qualitative and quantitative composition in terms of active principles, with mention of the international non-proprietary name recommended by the World Health Organization, where such name exists. U.K.

4 Manufacturing authorization, if any. U.K.

5 Marketing authorization, if any. U.K.

6 Summary of the characteristics of the veterinary medicinal product(s) prepared in accordance with Article 5a of Directive 81/851/EEC. U.K.

A. Safety documentation U.K.

A.0. Expert report U.K.

A.1. Precise identification of the substance concerned by the application U.K.

1.1 International non-proprietary name (INN). U.K.

1.2 International Union of Pure and Applied Chemistry (IUPAC) name. U.K.

1.3 Chemical Abstract Service (CAS) name. U.K.

1.4 Classification: U.K.

• therapeutic;

• pharmacological.

1.5 Synonyms and abbreviations. U.K.

1.6 Structural formula. U.K.

1.7 Molecular formula. U.K.

1.8 Molecular weight. U.K.

1.9 Degree of impurity. U.K.

1.10 Qualitative and quantitative composition of impurities. U.K.

1.11 Description of physical properties: U.K.

• melting point;

• boiling point;

• vapour pressure;

• solubility in water and organic solvents, expressed in grams per litre, with indication of temperature;

• density;

• refractive index, rotation, etc.

A.2. Relevant pharmacological studies U.K.

2.1 Pharmacodynamics. U.K.

2.2 Pharmacokinetics. U.K.

A.3. Toxicological studies U.K.

3.1 Single dose toxicity. U.K.

3.2 Repeated dose toxicity. U.K.

3.3 Tolerance in the target species of animal. U.K.

3.4 Reproductive toxicity, including teratogenicity. U.K.

3.4.1 Study of the effects on reproduction. U.K.

3.4.2 Embryotoxicity/fetotoxicity, including teratogenicity. U.K.

3.5 Mutagenicity. U.K.

3.6 Carcinogenicity. U.K.

A.4. Studies of other effects U.K.

4.1 Immunotoxicity. U.K.

4.2 Microbiological properties of residues. U.K.

4.2.1 On the human gut flora; U.K.

4.2.2 On the organisms and microorganisms used for industrial food-processing. U.K.

4.3 Observations in humans. U.K.

B. Residue documentation U.K.

B.0 Expert report U.K.

B.1. Precise identification of the substance concerned by the application U.K.

The substance concerned should be identified in accordance with point A.1. However, where the application relates to one or more veterinary medicinal products, the product itself should be identified in detail, including:

• qualitative and quantitative composition;

• purity;

• identification of the manufacturer's batch used in the studies; relationship to the final product;

• specific activity and radio-purity of labelled substances;

• position of labelled atoms on the molecule.

B.2. Residue studies U.K.

2.1 Pharmacokinetics U.K.

(absorption, distribution, biotransformation, excretion).

2.2 Depletion of residues. U.K.

2.3 Elaboration of maximum residue limits (MRLS). U.K.

B3. Routine analytical method for the detection of residues U.K.

3.1 Description of the method. U.K.

3.2 Validation of the method. U.K.

3.2.1 specificity; U.K.

3.2.2 accuracy, including sensitivity; U.K.

3.2.3 precision; U.K.

3.2.4 limit of detection; U.K.

3.2.5 limit of quantitation; U.K.

3.2.6 practicability and applicability under normal laboratory conditions; U.K.

3.2.7 susceptibility to interference.] U.K.

(1)

OJ No C 61, 10. 3. 1989. p. 5.

(2)

OJ No C 96, 17. 4. 1990, p. 273.

(3)

OJ No C 201, 17. 8. 1989, p. 1.

(4)

OJ No L 317, 6. 11. 1981, p. 16.

(5)

OJ No L 15, 17. 1. 1987, p. 34.

(6)

[F1 OJ L 214, 24.8.1993, p. 1 ]

(7)

[F2 OJ L 184, 17.7.1999, p. 23 .]

Textual Amendments

F1 Substituted by Council Regulation (EC) No 1308/1999 of 15 June 1999 amending Regulation (EC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin.

F2 Substituted by Council Regulation (EC) No 806/2003 of 14 April 2003 adapting to Decision 1999/468/EC the provisions relating to committees which assist the Commission in the exercise of its implementing powers laid down in Council instruments adopted in accordance with the consultation procedure (qualified majority).